2,6-dimethyl-N-[4-(methylsulfanyl)phenyl]furo[2,3-d]pyrimidin-4-amine | 1392817-31-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃[2,3-d]嘧啶
• 英文名称: 2,6-dimethyl-N-[4-(methylsulfanyl)phenyl]furo[2,3-d]pyrimidin-4-amine
• 英文别名: 2,6-Dimethyl-N-[4-(methylsulfanyl)phenyl]furo[2,3-d]pyrimidin-4-amine；2,6-dimethyl-N-(4-methylsulfanylphenyl)furo[2,3-d]pyrimidin-4-amine
• CAS: 1392817-31-0
• 化学式: C₁₅H₁₅N₃OS
• 分子量: 285.37
• InChiKey: KDWQAZJGTLQQBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  76.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,6-dimethyl-N-[4-(methylsulfanyl)phenyl]furo[2,3-d]pyrimidin-4-amine 、 硫酸二甲酯 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.5h， 以52%的产率得到N,2,6-trimethyl-N-[4-(methylsulfanyl)phenyl]furo[2,3-]pyrimidin-4-amine
  参考文献：
  名称：

  [EN] BICYCLIC AND TRICYCLIC PYRIMIDINE TYROSINE KINASE INHIBITORS WITH ANTITUBULIN ACTIVITY AND METHODS OF TREATING A PATIENT
  [FR] INHIBITEURS PYRIMIDINES BICYCLIQUES ET TRICYCLIQUES DE TYROSINE KINASE AYANT UNE ACTIVITÉ ANTITUBULINE, ET MÉTHODES DE TRAITEMENT D'UN PATIENT

  摘要：

  公开号：

  WO2012106522A3
• 作为产物：
  描述：

  2,6-dimethylfuro[2,3-d]pyrimidin-4(3H)-one 在 盐酸 、 三氯氧磷 作用下， 以 异丙醇 为溶剂， 反应 2.0h， 生成 2,6-dimethyl-N-[4-(methylsulfanyl)phenyl]furo[2,3-d]pyrimidin-4-amine
  参考文献：
  名称：

  [EN] BICYCLIC AND TRICYCLIC PYRIMIDINE TYROSINE KINASE INHIBITORS WITH ANTITUBULIN ACTIVITY AND METHODS OF TREATING A PATIENT
  [FR] INHIBITEURS PYRIMIDINES BICYCLIQUES ET TRICYCLIQUES DE TYROSINE KINASE AYANT UNE ACTIVITÉ ANTITUBULINE, ET MÉTHODES DE TRAITEMENT D'UN PATIENT

  摘要：

  公开号：

  WO2012106522A3

文献信息

• Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient
  申请人：Gangjee Aleem

  公开号：US09139590B2

  公开（公告）日：2015-09-22

  Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity are provided in the present invention. The compositions of the present invention possess dual activity in a single agent of potent vascular endothelial growth factor receptor inhibitory activity as well as antitubulin activity. Water soluble salts of these compositions are also described. Methods of treating a patient having cancer, macular degeneration, and arthritis with the compositions and salts thereof of the present invention are disclosed.

  本发明提供了具有抗微管蛋白活性的双环和三环嘧啶酪氨酸激酶抑制剂。本发明的组合物具有单一制剂中的强效血管内皮生长因子受体抑制活性和抗微管蛋白活性的双重活性。还描述了这些组合物的水溶性盐。本发明还揭示了使用这些组合物及其盐治疗患有癌症、黄斑变性和关节炎的患者的方法。
• BICYCLIC AND TRICYCLIC PYRIMIDINE TYROSINE KINASE INHIBITORS WITH ANTITUBULIN ACTIVITY AND METHODS OF TREATING A PATIENT
  申请人：Duquesne University of The Holy Spirit

  公开号：EP2670244B1

  公开（公告）日：2018-04-11
• Bicyclic and Tricyclic Pyrimidine Tyrosine Kinase Inhibitors with Antitubulin Activity and Methods of Treating a Patient
  申请人：Duquesne University of the Holy Spirit

  公开号：US20160009731A1

  公开（公告）日：2016-01-14

  Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity are provided in the present invention. The compositions of the present invention possess dual activity in a single agent of potent vascular endothelial growth factor receptor inhibitory activity as well as antitubulin activity. Water soluble salts of these compositions are also described. Methods of treating a patient having cancer, macular degeneration, and arthritis with the compositions and salts thereof of the present invention are disclosed.
• Bicyclic and Tricyclic Pyrimidine Tyrosine Kinase Inhibitors with Antitubulin Activity and Methods of Treating A Patient
  申请人：Duquesne University of the Holy Spirit

  公开号：US20210032266A1

  公开（公告）日：2021-02-04

  Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity are provided in the present invention. The compositions of the present invention possess dual activity in a single agent of potent vascular endothelial growth factor receptor inhibitory activity as well as antitubulin activity. Water soluble salts of these compositions are also described. Methods of treating a patient having cancer, macular degeneration, and arthritis with the compositions and salts thereof of the present invention are disclosed.
• US9139590B2
  申请人：——

  公开号：US9139590B2

  公开（公告）日：2015-09-22