11-Benzyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9-trien-12-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: 11-Benzyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9-trien-12-one
• 化学式: C₁₆H₁₄N₂OS
• 分子量: 282.4
• InChiKey: OJDHMQURQCZOFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  60.9
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] COMPOUNDS FOR TREATING RESPIRATORY SYNCYTIAL VIRUS INFECTIONS<br/>[FR] COMPOSÉS POUR LE TRAITEMENT D'INFECTIONS PAR LE VIRUS RESPIRATOIRE SYNCYTIAL
  申请人：BIOTA PHARMACEUTICALS INC

  公开号：WO2016133888A1

  公开（公告）日：2016-08-25

  The present disclosure provides compounds useful in the treatment of viral infections, in particular respiratory syncytial viral (RSV) infections. In one aspect of the invention, there is provided compounds of the formula (I): These an additional compounds are provided which are advantageously used in methods of treating RSV wherein an effective amount of a compound or pharmaceutical compound thereof is administered to a patient in need thereof. Processes for preparing the compounds and intermediates used in their preparation are also provided.

  本公开提供了在治疗病毒感染，特别是呼吸道合胞病毒（RSV）感染方面有用的化合物。在发明的一个方面，提供了一种具有以下结构的化合物（I）：此外，还提供了其他有益的化合物，这些化合物在治疗RSV的方法中得到优越应用，其中将有效量的化合物或其药用化合物给予需要的患者。还提供了制备这些化合物和用于制备它们的中间体的方法。
• SMALL MOLECULE INHIBITORS OF NECROPTOSIS
  申请人：President and Fellows of Harvard College

  公开号：EP3000468A1

  公开（公告）日：2016-03-30

  The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-α) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I)-(VIII) and by Compounds (I)-(I), (13)-(26), (27)-(33), (48)-(57), and (58)-(70). These necrostatins are shown to inhibit TNF-α induced necroptosis in FADD-deficient variant of human Jurkat T cells. The invention further features pharmaceutical compositions featuring necrostatins. The compounds and compositions of the invention may also be used to treat disorders where necroptosis is likely to play a substantial role.

  本发明具有一系列抑制肿瘤坏死因子α（TNF-α）诱导坏死的杂环衍生物。本发明的杂环化合物由式(I)-(VIII)和化合物(I)-(I)、(13)-(26)、(27)-(33)、(48)-(57)和(58)-(70)描述。这些坏死素能抑制 FADD 缺陷变体人 Jurkat T 细胞中 TNF-α 诱导的坏死。本发明还具有以坏死素为特征的药物组合物。本发明的化合物和组合物还可用于治疗坏死蛋白可能起重要作用的疾病。
• Treating male senescence
  申请人：National Institute of Biological Sciences, Beijing

  公开号：US11090307B2

  公开（公告）日：2021-08-17

  The invention provides methods of treating male reproductive senescence comprising administering to a male in need thereof a necroptosis inhibitor, including inhibitors of RIP1, RIP3 or MLKL. The invention also provides pharmaceutical compositions comprising a necroptosis inhibitor and a second different drug for treating male senescence.

  本发明提供了治疗男性生殖衰老的方法，包括向有需要的男性施用坏死抑制剂，包括RIP1、RIP3或MLKL的抑制剂。本发明还提供了包含坏死抑制剂和用于治疗男性衰老的第二种不同药物的药物组合物。
• Necroptosis Inhibitors and Methods of Use Therefor
  申请人：Yuan Junying

  公开号：US20140066466A1

  公开（公告）日：2014-03-06

  Described herein are compositions that inhibit the production of TNFα downstream of CD40 activation. As such, also described are various methods of using compositions exhibiting this activity for the treatment or prevention of inflammatory diseases associated with TNFα production or CD40 activation.
• Treating Male Senescence
  申请人：National Institute of Biological Sciences, Beijing

  公开号：US20200046714A1

  公开（公告）日：2020-02-13

  The invention provides methods of treating male reproductive senescence comprising administering to a male in need thereof a necroptosis inhibitor, including inhibitors of RIP1, RIP3 or MLKL. The invention also provides pharmaceutical compositions comprising a necroptosis inhibitor and a second different drug for treating male senescence.