2-[2-Hydroxyethyl-[[prop-2-enoxy(prop-2-enyl)phosphoryl]methyl]amino]ethanol

• 分子结构分类: 有机化合物 - 有机磷化合物
• 英文名称: 2-[2-Hydroxyethyl-[[prop-2-enoxy(prop-2-enyl)phosphoryl]methyl]amino]ethanol
• 英文别名: 2-[2-hydroxyethyl-[[prop-2-enoxy(prop-2-enyl)phosphoryl]methyl]amino]ethanol
• 化学式: C₁₁H₂₂NO₄P
• 分子量: 263.27
• InChiKey: LZRAXOMLOLLQJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  17
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  70
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] METHOD FOR THE SYNTHESIS OF AMINOALKYLENEPHOSPHONIC ACID<br/>[FR] PROCÉDÉ DE SYNTHÈSE D'ACIDE AMINOALKYLÈNEPHOSPHONIQUE
  申请人：STRAITMARK HOLDING AG

  公开号：WO2014012987A1

  公开（公告）日：2014-01-23

  The present invention is related to a method for the synthesis of an aminoalkylenephosphonic acid or its phosphonate esters comprising the following steps: a) forming, in the presence of an aldehyde or ketone and an acid catalyst, a reaction mixture by mixing a compound comprising at least one HNR1R2 moiety or a salt thereof, with a compound having one or more P-O-P anhydride moieties, said moieties comprising one P atom at the oxidation state (+III) and one P atom at the oxidation state (+III) or (+V), wherein the ratio of moles of aldehyde or ketone to N-H moieties is 1 or more and wherein the ratio of N-H moieties to P-O-P anhydride moieties is 0.3 or more and, b) recovering the resulting aminoalkylenephosphonic acid comprising compound or its phosphonate esters.

  本发明涉及一种合成氨基烯膦酸或其膦酸酯的方法，包括以下步骤：a) 在醛或酮和酸催化剂的存在下，通过将至少含有一个HNR1R2基团或其盐的化合物与至少含有一个或多个P-O-P酸酐基团的化合物混合形成反应混合物，所述基团包括一个氧化态为(+III)的P原子和一个氧化态为(+III)或(+V)的P原子，其中醛或酮的摩尔比与N-H基团的比值为1或更多，N-H基团与P-O-P酸酐基团的比值为0.3或更多；b) 回收所得的氨基烯膦酸化合物或其膦酸酯。
• METHOD FOR THE SYNTHESIS OF AMINOALKYLENEPHOSPHONIC ACID
  申请人：STRAITMARK HOLDING AG

  公开号：US20150225431A1

  公开（公告）日：2015-08-13

  A method for the synthesis of an aminoalkylenephosphonic acid or its phosphonate esters including the following steps: a) forming, in the presence of an aldehyde or ketone and an acid catalyst, a reaction mixture by mixing a compound having at least one HNR 1 R 2 moiety or a salt thereof, with a compound having one or more P—O—P anhydride moieties, the moieties having one P atom at the oxidation state (+III) and one P atom at the oxidation state (+III) or (+V), wherein the ratio of moles of aldehyde or ketone to N—H moieties is 1 or more and wherein the ratio of N—H moieties to P—O—P anhydride moieties is 0.3 or more, and b) recovering the resulting aminoalkylenephosphonic acid having compound or its phosphonate esters.

  一种合成氨基烷基膦酸或其膦酸酯的方法，包括以下步骤：a)在醛或酮和酸催化剂存在下，通过将至少具有一个HNR1R2基团或其盐的化合物与具有一个或多个P-O-P酸酐基团的化合物混合而形成反应混合物，其中该基团具有一个P原子在氧化态(+III)，另一个P原子在氧化态(+III)或(+V)，其中醛或酮的摩尔比与N-H基团的摩尔比为1或更多，N-H基团与P-O-P酸酐基团的摩尔比为0.3或更多，b)回收所得的氨基烷基膦酸化合物或其膦酸酯。
• Method for the synthesis of aminoalkylenephosphonic acid
  申请人：MONSANTO TECHNOLOGY LLC

  公开号：US10280189B2

  公开（公告）日：2019-05-07

  A method for the synthesis of an aminoalkylenephosphonic acid or its phosphonate esters including the following steps: a) forming, in the presence of an aldehyde or ketone and an acid catalyst, a reaction mixture by mixing a compound having at least one HNR1R2 moiety or a salt thereof, with a compound having one or more P—O—P anhydride moieties, the moieties having one P atom at the oxidation state (+III) and one P atom at the oxidation state (+III) or (+V), wherein the ratio of moles of aldehyde or ketone to N—H moieties is 1 or more and wherein the ratio of N—H moieties to P—O—P anhydride moieties is 0.3 or more, and b) recovering the resulting aminoalkylenephosphonic acid having compound or its phosphonate esters.

  一种合成氨基烯基膦酸或其膦酸酯的方法，包括以下步骤：a) 在醛或酮和酸催化剂存在下，将具有至少一个 HNR1R2 基团的化合物或其盐 与具有一个或多个 P-O-P 酸酐基团的化合物混合，形成反应混合物、这些分子具有一个氧化态为(+III)的P原子和一个氧化态为(+III)或(+V)的P原子，其中醛或酮的摩尔数与N-H分子数之比为1或以上，N-H分子数与P-O-P酸酐分子数之比为0.3 或更多，以及 b) 回收所得的具有化合物或其膦酸酯的氨基烷基膦酸。