[2-[2-[(2R)-4-[(5E,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl]oxy-3,3-dimethyl-1-oxo-1-[[3-oxo-3-[2-[2-[2-[2-[(3R,4R)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]ethoxycarbonylamino]ethoxycarbonylamino]ethyldisulfanyl]ethylamino]propyl]amino]butan-2-yl]oxycarbonylphenoxy]carbonylphenyl] pyridine-3-carboxylate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: [2-[2-[(2R)-4-[(5E,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl]oxy-3,3-dimethyl-1-oxo-1-[[3-oxo-3-[2-[2-[2-[2-[(3R,4R)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]ethoxycarbonylamino]ethoxycarbonylamino]ethyldisulfanyl]ethylamino]propyl]amino]butan-2-yl]oxycarbonylphenoxy]carbonylphenyl] pyridine-3-carboxylate
• 化学式: C₆₅H₈₆N₆O₁₈S₂
• 分子量: 1303.5
• InChiKey: YCFMNOGZZIJLKK-AIMLIJFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  91
• 可旋转键数：
  46
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  388
• 氢给体数：
  8
• 氢受体数：
  22

文献信息

• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC SYNDROME AND DIABETES<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DU SYNDROME MÉTABOLIQUE ET DU DIABÈTE
  申请人：KANDULA MAHESH

  公开号：WO2014087307A2

  公开（公告）日：2014-06-12

  The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II; and methods for treating or preventing metabolic syndrome and diabetes may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of diabetes mellitus, obesity, lipid disorders, hypertriglyceridemia, hyperglycemia, hyperinsulinemia and insulin resistance.