9,9-difluoro-10-(3-methylphenyl)-5a,6,7,7a,8,10-hexahydro-5H-cyclopenta[g][3]benzazepine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吖庚因类
• 英文名称: 9,9-difluoro-10-(3-methylphenyl)-5a,6,7,7a,8,10-hexahydro-5H-cyclopenta[g][3]benzazepine
• 化学式: C₂₀H₂₁F₂N
• 分子量: 313.4
• InChiKey: XVBAJMXKFHZNHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• BENZAZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF
  申请人：ABT Holding Company

  公开号：EP2938345A2

  公开（公告）日：2015-11-04
• [EN] BENZAZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF<br/>[FR] BENZAZÉPINES EN TANT QUE LIGANDS DU RÉCEPTEUR 5-HT2C DE LA SÉROTONINE ET LEURS UTILISATIONS
  申请人：ABT HOLDING CO

  公开号：WO2014100815A2

  公开（公告）日：2014-06-26

  The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are benzazepine compounds. These compounds are serotonin receptor (5-HT2c) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT2c) is desired (e.g. addiction, anxiety, depression, obesity, and others).