5-[[(2R)-azetidin-2-yl]methoxy]-2-chloropyridine;(1S,2S,4R)-2-(6-chloropyridin-3-yl)-7-azabicyclo[2.2.1]heptane

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 地棘蛙素类似物
• 英文名称: 5-[[(2R)-azetidin-2-yl]methoxy]-2-chloropyridine;(1S,2S,4R)-2-(6-chloropyridin-3-yl)-7-azabicyclo[2.2.1]heptane
• 化学式: C20H24Cl2N4O
• 分子量: 407.3
• InChiKey: NIGHENGTJWKKAM-HYYIULOCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.82
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  59.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• NEURONAL IMAGING AND TREATMENT
  申请人：Tylerton International Holdings Inc.

  公开号：EP2948188A1

  公开（公告）日：2015-12-02
• [EN] NEURONAL IMAGING AND TREATMENT<br/>[FR] IMAGERIE NEURONALE ET TRAITEMENT
  申请人：TYLERTON INTERNAT HOLDINGS INC

  公开号：WO2014115152A1

  公开（公告）日：2014-07-31

  A method is disclosed herein for imaging at least one autonomic nervous system synaptic center in a subject, as well as a method of diagnosing and/or monitoring a medical condition or disease associated with an autonomic nervous system, and a method of guiding a therapy of such a medical condition or disease. The methods comprise administering to the subject a radioactive tracer which selectively binds to autonomic nervous system synapses; measuring radioactive emission of the tracer to obtain data describing a distribution of the tracer in the body; and analyzing the data in order to identify at least one region exhibiting a high concentration of the tracer. Further disclosed herein are radioactive tracers, uses thereof, and an apparatus, for use in a method disclosed herein.