4-(Piperidin-1-yl)-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: 4-(Piperidin-1-yl)-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine
• 英文别名: 12-piperidin-1-yl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(12),2(6),8,10-tetraene
• 化学式: C₁₄H₁₇N₃S
• 分子量: 259.37
• InChiKey: MEWMZQHFPJUCNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  57.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• IRAK INHIBITORS AND USES THEREOF
  申请人：Romero Donna L.

  公开号：US20120283238A1

  公开（公告）日：2012-11-08

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供了化合物、其组合物以及使用它们的方法。
• INHIBITORS OF CYCLIC AMP PHOSPHODIESTERASES
  申请人：Hoffman Charles S.

  公开号：US20100227853A1

  公开（公告）日：2010-09-09

  Recombinant fission yeast cells and methods of using them are described, which provide for identification of chemical and biological inhibitors or activators of a target exogenous phosphodiesterase (PDE). The invention provides, in some aspects, compounds that inhibit cAMP PDE activity and compositions that include such compounds. The invention, in part, also includes methods of using cAMP PDE-inhibiting compounds in the treatment of cAMP PDE-associated diseases and/or disorders.
• US9340554B2
  申请人：——

  公开号：US9340554B2

  公开（公告）日：2016-05-17