Methyl 3-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-3-carboxylate

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: Methyl 3-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-3-carboxylate
• 英文别名: methyl 3-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-3-carboxylate
• 化学式: C₁₆H₁₉Cl₂NO₂
• 分子量: 328.2
• InChiKey: WSEZNTAWKAGWRC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• HIGH THROUGHPUT SCREENING OF AGENTS ON DOPAMINERGIC NEURONS
  申请人：Hadasit Medical Research Services and Development Ltd.

  公开号：EP2956539B1

  公开（公告）日：2019-10-02
• [EN] HIGH THROUGHPUT SCREENING OF AGENTS ON DOPAMINERGIC NEURONS<br/>[FR] CRIBLAGE À HAUT DÉBIT POUR IDENTIFIER LES AGENTS AYANT UNE ACTION SUR LES NEURONES DOPAMINERGIQUES
  申请人：CELL CURE NEUROSCIENCES LTD

  公开号：WO2014125481A1

  公开（公告）日：2014-08-21

  A method of determining whether an agent is a neuroeffector is disclosed. The method comprises: (a) labeling dopaminergic neurons which are comprised in a mixed population of cells with a fluorescent dopamine analog; (b) measuring a level of fluorescence in the mixed population of cells; (c) exposing the mixed population of cells to the agent; (d) remeasuring a level of fluorescence in the mixed population of cells, wherein a change in the level of fluorescence is indicative of the substance being a neuroeffector.