7-Ethyl-[1,3]thiazolo[5,4-d]pyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 1,3-噻唑并[5,4-d]嘧啶
• 英文名称: 7-Ethyl-[1,3]thiazolo[5,4-d]pyrimidine
• 英文别名: 7-ethyl-[1,3]thiazolo[5,4-d]pyrimidine
• 化学式: C₇H₇N₃S
• 分子量: 165.22
• InChiKey: FTEVNRXRZVZLEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  66.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
  申请人：Incyte Corporation

  公开号：US11130767B2

  公开（公告）日：2021-09-28

  This application relates to derivatives of Formula I: and pharmaceutically acceptable salts thereof, which are inhibitors of PI3K, and compositions and methods of treatment related thereto.

  本申请涉及式 I 的衍生物： 及其药学上可接受的盐，它们是 PI3K 的抑制剂，以及与之相关的组合物和治疗方法。
• SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME
  申请人：BlinkBio, Inc.

  公开号：US20190290771A1

  公开（公告）日：2019-09-26

  Described herein are silicon based conjugates capable of delivering one or more payload moieties to a target cell or tissue. Contemplated conjugates may include a silicon-heteroatom core, one or more optional catalytic moieties, a targeting moiety that permits accumulation of the conjugate within a target cell or tissue, one or more payload moieties (e.g., a therapeutic agent or imaging agent), and two or more non-interfering moieties covalently bound to the silicon-heteroatom core.
• BICYCLIC HETEROARYLAMINOALKYL PHENYL DERIVATIVES AS PI3K INHIBITORS
  申请人：Incyte Corporation

  公开号：US20200247820A1

  公开（公告）日：2020-08-06

  This application relates to derivatives of Formula I: and pharmaceutically acceptable salts thereof, which are inhibitors of PI3K, and compositions and methods of treatment related thereto.