8-Azabicyclo[3.2.1]octane-2,8-dicarboxylic acid

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: 8-Azabicyclo[3.2.1]octane-2,8-dicarboxylic acid
• 英文别名: 8-azabicyclo[3.2.1]octane-2,8-dicarboxylic acid
• 化学式: C₉H₁₃NO₄
• 分子量: 199.2
• InChiKey: HTMSGWHMYLPXOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  77.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [1,2,4]triazolo[1,5and#8208;A]pyrimidine compounds as PDE2 inhibitors
  申请人：Janssen Pharmaceutica NV

  公开号：US10947242B2

  公开（公告）日：2021-03-16

  The present invention relates to novel [1,2,4]triazolo[1,5-a]pyrimidin-yl derivatives as inhibitors of phosphodiesterase 2 (PDE2). The invention is also directed to pharmaceutical compositions comprising the compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which PDE2 is involved, such as neurological and psychiatric disorders.

  本发明涉及作为磷酸二酯酶 2（PDE2）抑制剂的新型[1,2,4]三唑并[1,5-a]嘧啶基衍生物。本发明还涉及包含这些化合物的药物组合物、制备这些化合物和组合物的工艺，以及使用这些化合物和组合物预防和治疗涉及 PDE2 的疾病，如神经和精神疾病。
• [1,2,4]triazolo[1,5-a]pyrimidine compounds as PDE2 inhibitors
  申请人：Janssen Pharmaceutica NV

  公开号：US11053248B2

  公开（公告）日：2021-07-06

  The present invention relates to novel [1,2,4]triazolo[1,5-a]pyrimidin-yl derivatives as inhibitors of phosphodiesterase 2 (PDE2). The invention is also directed to pharmaceutical compositions comprising the compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which PDE2 is involved, such as neurological and psychiatric disorders.

  本发明涉及作为磷酸二酯酶 2（PDE2）抑制剂的新型[1,2,4]三唑并[1,5-a]嘧啶基衍生物。本发明还涉及包含这些化合物的药物组合物、制备这些化合物和组合物的工艺，以及使用这些化合物和组合物预防和治疗涉及 PDE2 的疾病，如神经和精神疾病。
• [1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PDE2 INHIBITORS
  申请人：Janssen Pharmaceutica NV

  公开号：EP3535267B1

  公开（公告）日：2020-12-30
• [1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AS PDE2 INHIBITORS
  申请人：Janssen Pharmaceutica NV

  公开号：EP3535269A1

  公开（公告）日：2019-09-11
• [1,2,4]TRIAZOLO[1,5‐A]PYRIMIDINE COMPOUNDS AS PDE2 INHIBITORS
  申请人：Janssen Pharmaceutica NV

  公开号：US20190276462A1

  公开（公告）日：2019-09-12

  The present invention relates to novel [1,2,4]triazolo[1,5-a]pyrimidin-yl derivatives as inhibitors of phosphodiesterase 2 (PDE2). The invention is also directed to pharmaceutical compositions comprising the compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which PDE2 is involved, such as neurological and psychiatric disorders.