N-(3-chlorophenyl)thieno[2,3-d]pyrimidin-4-amine | 560998-98-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: N-(3-chlorophenyl)thieno[2,3-d]pyrimidin-4-amine
• CAS: 560998-98-3
• 化学式: C₁₂H₈ClN₃S
• 分子量: 261.735
• InChiKey: WKUSRXUEHXLVPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-氯噻吩[2,3-D]嘧啶 、 3-氯苯胺 在 盐酸 作用下， 以 水 、 异丙醇 为溶剂， 生成 N-(3-chlorophenyl)thieno[2,3-d]pyrimidin-4-amine
  参考文献：
  名称：

  Design, synthesis, and in vivo activity of novel inhibitors of delta-5 desaturase for the treatment of metabolic syndrome

  摘要：

  The synthesis, SAR, and in vivo activity of inhibitors of delta-5 desaturase are described. Ring-constraint of the initial series provided access to a variety of in vitro active chemotypes, from which the indazole was selected. Examples from the indazole series displayed in vivo activity in reducing the enzymatic activity of liver delta-5 desaturase. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.07.066

文献信息

• Methods and compositions for the treatment of pain, inflammation and cancer
  申请人：Barbosa Joseph

  公开号：US20080194557A1

  公开（公告）日：2008-08-14

  This invention relates to methods of treating, managing and preventing pain, inflammation, cancer, and ocular diseases and disorders, and to compounds and pharmaceutical compositions useful in such methods.

  本发明涉及用于治疗、管理和预防疼痛、炎症、癌症和眼部疾病和障碍的方法，以及在这些方法中有用的化合物和制药组合物。
• Methods and compositions for the treatment of body composition disorders
  申请人：Barbosa Joseph

  公开号：US20080200458A1

  公开（公告）日：2008-08-21

  This invention relates to methods of treating, managing and preventing body composition disorders, and to compounds and pharmaceutical compositions useful in such methods.

  本发明涉及治疗、管理和预防身体组成失调的方法，以及在这些方法中有用的化合物和制药组合物。
• [EN] METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN, INFLAMMATION AND CANCER<br/>[FR] MÉTHODES ET COMPOSITIONS UTILISÉS DANS LE TRAITEMENT DE LA DOULEUR, DE L'INFLAMMATION ET DU CANCER
  申请人：LEXICON PHARMACEUTICALS INC

  公开号：WO2008089307A2

  公开（公告）日：2008-07-24

  [EN] This invention relates to methods of treating, managing and preventing pain, inflammation, cancer, and ocular diseases and disorders, and to compounds and pharmaceutical compositions useful in such methods.
  [FR] Cette invention porte sur des méthodes de traitement, de gestion et de prévention de la douleur, de l'inflammation, du cancer et de maladies et troubles oculaires, ainsi que sur des composés et des compositions pharmaceutiques utilisées dans ces méthodes.
• [EN] METHODS AND COMPOSITIONS FOR THE TREATMENT OF BODY COMPOSITION DISORDERS<br/>[FR] MÉTHODES ET COMPOSITIONS UTILISÉES DANS LE TRAITEMENT DE TROUBLES CORPORELS
  申请人：LEXICON PHARMACEUTICALS INC

  公开号：WO2008089310A2

  公开（公告）日：2008-07-24

  [EN] This invention relates to methods of treating, managing and preventing body composition disorders, and to compounds and pharmaceutical compositions useful in such methods.
  [FR] Cette invention porte sur des méthodes de traitement, de gestion et de prévention de troubles corporels, ainsi que sur des composés et des compositions pharmaceutiques utilisés dans ces méthodes.
• Design, synthesis, and in vivo activity of novel inhibitors of delta-5 desaturase for the treatment of metabolic syndrome
  作者：Simon D.P. Baugh、Praveen K. Pabba、Joseph Barbosa、Eric Coulter、Urvi Desai、Jason P. Gay、Suma Gopinathan、Qiang Han、Rajee Hari、S. David Kimball、Huy V. Nguyen、Chi-You Ni、David R. Powell、Arian Smith、Kristen M. Terranova、Alan Wilson、Xuan-Chuan Yu、Victoria K. Lombardo

  DOI：10.1016/j.bmcl.2015.07.066

  日期：2015.9

  The synthesis, SAR, and in vivo activity of inhibitors of delta-5 desaturase are described. Ring-constraint of the initial series provided access to a variety of in vitro active chemotypes, from which the indazole was selected. Examples from the indazole series displayed in vivo activity in reducing the enzymatic activity of liver delta-5 desaturase. (C) 2015 Elsevier Ltd. All rights reserved.