2,8-diazaspiro<5.5>undecane dihydrochloride | 1203681-46-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 2,8-diazaspiro<5.5>undecane dihydrochloride
• 英文别名: 2,8-diaza-spiro[5.5]undecane; dihydrochloride；2,8-Diaza-spiro[5.5]undecan; Dihydrochlorid；2,8-Diazaspiro[5.5]undecane, (Hydrochloride) (1:2)；2,8-diazaspiro[5.5]undecane;hydrochloride
• CAS: 1203681-46-2
• 化学式: C₉H₁₈N₂*2ClH
• 分子量: 227.177
• InChiKey: ABQIHOAAYNEJMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.16
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-乙基-6,7,8-三氟-1,4-二氢-4-氧代喹啉-2-羧酸 、 2,8-diazaspiro<5.5>undecane dihydrochloride 以 乙腈 为溶剂， 反应 2.0h， 以63%的产率得到1-ethyl-6,8-difluoro-1,4-dihydro-7-(2,8-diazaspiro[5.5]undec-2-yl)-4-oxo-3-quinolinecarboxylic acid
  参考文献：
  名称：

  Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships

  摘要：

  A series of fluoroquinolone antibacterials having the 7-position (10-position of pyridobenzoxazines) substituted with 2,7-diazaspiro[4.4]nonane (4b), 1,7-diazaspiro[4.4]nonane (5a), or 2,8-diazaspiro[5.5]undecane (6b) was prepared, and their biological activities were compared with piperazine and pyrrolidine substituted analogues. Most exhibited potent Gram-positive and Gram-negative activity, especially when side chain 4b was N-alkylated.

  DOI：

  10.1021/jm00170a035

文献信息

• Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships
  作者：Townley P. Culbertson、Joseph P. Sanchez、Laura Gambino、Josephine A. Sesnie

  DOI：10.1021/jm00170a035

  日期：1990.8

  A series of fluoroquinolone antibacterials having the 7-position (10-position of pyridobenzoxazines) substituted with 2,7-diazaspiro[4.4]nonane (4b), 1,7-diazaspiro[4.4]nonane (5a), or 2,8-diazaspiro[5.5]undecane (6b) was prepared, and their biological activities were compared with piperazine and pyrrolidine substituted analogues. Most exhibited potent Gram-positive and Gram-negative activity, especially when side chain 4b was N-alkylated.