(1S,5R)-3-tert-butyl-8-ethyl-8-azabicyclo[3.2.1]octane

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: (1S,5R)-3-tert-butyl-8-ethyl-8-azabicyclo[3.2.1]octane
• 化学式: C₁₃H₂₅N
• 分子量: 195.34
• InChiKey: OJNOBWOEXSUCQI-YOGCLGLASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• C10-Cyclic Substituted 13-Membered Macrolides and Uses Thereof
  申请人：Zikani Therapeutics, Inc.

  公开号：US20220177508A1

  公开（公告）日：2022-06-09

  Provided are 13-membered macrolides for the treatment of infectious diseases. The 13-membered macrolides described herein are azaketolides. Also provided are methods for preparing the 13-membered macrolides, pharmaceutical compositions comprising the 13-membered macrolides, and methods of treating infectious diseases, and in particular, disease resulting from Gram negative bacteria using the disclosed macrolides.