8-(甲基磺酰基)-8-氮杂双环[3.2.1]辛-3-胺 | 1249024-78-9

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 中文名称: 8-(甲基磺酰基)-8-氮杂双环[3.2.1]辛-3-胺
• 英文名称: 8-(Methylsulfonyl)-8-azabicyclo[3.2.1]octan-3-amine
• 英文别名: 8-methylsulfonyl-8-azabicyclo[3.2.1]octan-3-amine
• CAS: 1249024-78-9
• 化学式: C₈H₁₆N₂O₂S
• mdl: MFCD14602631
• 分子量: 204.29
• InChiKey: WCTCMYLESNOTNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  71.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives
  申请人：The Liver Company Inc.

  公开号：US11136290B2

  公开（公告）日：2021-10-05

  Provided is a compound of Formula (I): wherein the variable groups are defined herein.

  提供的是一种式 (I) 化合物： 其中变量组在此定义。
• Triterpene amine derivatives
  申请人：DFH THERAPEUTICS

  公开号：US11236122B2

  公开（公告）日：2022-02-01

  The present invention concerns novel pharmaceutically active triterpene amine derivatives, pharmaceutical compositions containing the same, their use as medicaments, and the use of the compounds for the manufacture of specific medicaments. The present invention also concerns a method of treatment involving administration of the triterpene amine compounds. Specifically, the compounds are derivatives of betulinic acid having substitutions at one or more of the C-3, C-28 and C-19 positions as further described herein. The novel compounds are useful as antiretroviral agents. In particular, the novel compounds are useful for the treatment of Human Immunodeficiency Virus-1 (HIV-1).

  本发明涉及新型具有药用活性的三萜胺衍生物、含有三萜胺衍生物的药物组合物、其作为药物的用途，以及使用这些化合物制造特定药物。本发明还涉及一种涉及三萜胺化合物给药的治疗方法。具体来说，这些化合物是白桦脂酸的衍生物，在 C-3、C-28 和 C-19 位上有一个或多个取代位，如本文进一步描述的那样。这些新型化合物可用作抗逆转录病毒药物。特别是，这些新型化合物可用于治疗人类免疫缺陷病毒-1（HIV-1）。
• TRITERPENE AMINE DERIVATIVES
  申请人：DFH THERAPEUTICS

  公开号：US20210253627A1

  公开（公告）日：2021-08-19

  The present invention concerns novel pharmaceutically active triterpene amine derivatives, pharmaceutical compositions containing the same, their use as medicaments, and the use of the compounds for the manufacture of specific medicaments. The present invention also concerns a method of treatment involving administration of the triterpene amine compounds. Specifically, the compounds are derivatives of betulinic acid having substitutions at one or more of the C-3, C-28 and C-19 positions as further described herein. The novel compounds are useful as antiretroviral agents. In particular, the novel compounds are useful for the treatment of Human Immunodeficiency Virus-1 (HIV-1).
• SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES
  申请人：The Liver Company Inc.

  公开号：US20220055985A1

  公开（公告）日：2022-02-24

  Provided is a compound of Formula (I): wherein the variable groups are defined herein.
• US7268150B2
  申请人：——

  公开号：US7268150B2

  公开（公告）日：2007-09-11