N-(2-hydroxyethyl)-1-thia-4-azaspiro[4.5]decan-3-one | 205173-21-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: N-(2-hydroxyethyl)-1-thia-4-azaspiro[4.5]decan-3-one
• 英文别名: 4-(2-Hydroxy-ethyl)-1-thia-4-aza-spiro[4.5]decan-3-one；4-(2-hydroxyethyl)-1-thia-4-azaspiro[4.5]decan-3-one
• CAS: 205173-21-3
• 化学式: C₁₀H₁₇NO₂S
• mdl: MFCD02044429
• 分子量: 215.316
• InChiKey: PYFRHVWIPXKAHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  65.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-氧-4-氮螺[4.5]癸烷 、 巯基乙酸 以 苯 为溶剂， 以62%的产率得到N-(2-hydroxyethyl)-1-thia-4-azaspiro[4.5]decan-3-one
  参考文献：
  名称：

  Synthesis ofN-(2-hydroxyalkyl)-4-thiazolidinones from oxazolidines

  摘要：

  The reaction of oxazolidines with mercaptoacetic acid affords N-(2-hydroxyalkyl)-4-thiazolidinones in 58-87% yield regardless of the position of the oxazolidine-iminoalcohol tautomeric equilibrium. The structures of the resulting compounds were confirmed by IR and H-1 NMR spectroscopy.

  DOI：

  10.1007/bf02495261

文献信息

• Synthesis ofN-(2-hydroxyalkyl)-4-thiazolidinones from oxazolidines
  作者：B. F. Kukharev、V. K. Stankevich、G. R. Klimenko

  DOI：10.1007/bf02495261

  日期：1997.12

  The reaction of oxazolidines with mercaptoacetic acid affords N-(2-hydroxyalkyl)-4-thiazolidinones in 58-87% yield regardless of the position of the oxazolidine-iminoalcohol tautomeric equilibrium. The structures of the resulting compounds were confirmed by IR and H-1 NMR spectroscopy.
• ——
  作者：B. F. Kukharev、V. K. Stankevich、G. R. Klimenko、E. N. Kovalyuk、V. V. Bayandin

  DOI：10.1023/a:1019545904261

  日期：——

  A one-pot procedure was developed for synthesis of N-(2-hydroxyethyl)-1,3-thiazolidin-4-ones in 64-68% yield by reactions of monoethanolamine with carbonyl compounds and mercaptoacetic acid. The synthesized compounds were characterized by IR and H-1 NMR spectra, and their anticorrosive properties were studied.