Hydroxy-phenyl-acetic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-3-YL ester | 51017-33-5

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: Hydroxy-phenyl-acetic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-3-YL ester
• 英文别名: [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] (2R)-2-hydroxy-2-phenylacetate
• CAS: 51017-33-5
• 化学式: C₁₆H₂₁NO₃
• 分子量: 275.34
• InChiKey: ZTVIKZXZYLEVOL-IZGVIRRGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

ADMET

毒理性

• 在妊娠和哺乳期间的影响

◉ 母乳喂养期间使用总结：目前没有关于在母乳喂养期间使用溴化霍马托品的信息。抗胆碱药物可能会干扰母乳喂养。单次剂量的眼科用溴化霍马托品不太可能干扰母乳喂养；然而，在长期使用期间，观察婴儿是否有泌乳减少的迹象（例如，不饱，体重增加不良）。为了显著减少使用眼药水后到达母乳中的药物量，可以在眼角处对泪管施加压力1分钟或更长时间，然后用吸收性纸巾去除多余的溶液。 ◉ 对哺乳婴儿的影响：截至修订日期，没有找到相关的已发布信息。 ◉ 对泌乳和母乳的影响：抗胆碱药可以在动物中抑制泌乳，显然是通过抑制生长激素和催产素的分泌。抗胆碱药物还可以减少非哺乳期女性的血清催乳素水平。已建立泌乳的母亲体内的催乳素水平可能不会影响她的哺乳能力。

◉ Summary of Use during Lactation:No information is available on the use of homatropine hydrobromide during breastfeeding. Anticholinergic drugs might interfere with breastfeeding. A single dose of ophthalmic homatropine hydrobromide is not likely to interfere with breastfeeding; however, during long-term use, observe the infant for signs of decreased lactation (e.g., insatiety, poor weight gain). To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue. ◉ Effects in Breastfed Infants:Relevant published information was not found as of the revision date. ◉ Effects on Lactation and Breastmilk:Anticholinergics can inhibit lactation in animals, apparently by inhibiting growth hormone and oxytocin secretion. Anticholinergic drugs can also reduce serum prolactin in nonnursing women. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

来源:Drugs and Lactation Database (LactMed)