tributyl(hexadecyl)-λ5-phosphane

• 分子结构分类: 有机化合物 - 有机磷化合物
• 英文名称: tributyl(hexadecyl)-λ5-phosphane
• 化学式: C₂₈H₆₁P
• 分子量: 428.8
• InChiKey: JSCPSRQATRVLGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.5
• 重原子数：
  29
• 可旋转键数：
  24
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• PROCESS FOR PRODUCING 1,1-DICHLORO-2,3,3,3-TETRAFLUOROPROPENE AND 2,3,3,3-TETRAFLUOROPROPENE
  申请人：SEKI Ryuji

  公开号：US20110319678A1

  公开（公告）日：2011-12-29

  To provide a process to produce 1,1-dichloro-2,3,3,3-tetrafluoropropene (CFO-1214ya) simply and economically without requiring purification of 1,1-dichloro-2,2,3,3,3-pentafluoropropane (HCFC-225ca) from the raw material component obtained as a mixture of isomers, i.e. dichloropentafluoropropane (HCFC-225) including HCFC-225ca and at the same time to produce simply and economically 2,3,3,3-tetrafluoropropene (HFO-1234yf) from 1-chloro-2,3,3,3-tetrafluoropropane (HCFC-244eb). A raw material composition comprising HCFC-244eb and HCFC-225 including HCFC-225ca is contacted with an alkali aqueous solution in the presence of a phase-transfer catalyst to produce CFO-1214ya from HCFC-225ca and at the same time to produce HFO-1234yf from HCFC-244eb.

  提供一种简单经济的方法来生产1,1-二氯-2,3,3,3-四氟丙烯（CFO-1214ya），无需从作为异构体混合物获得的原料组分中纯化1,1-二氯-2,2,3,3,3-五氟丙烷（HCFC-225ca），即二氯五氟丙烷（HCFC-225）包括HCFC-225ca，并同时简单经济地生产2,3,3,3-四氟丙烯（HFO-1234yf）从1-氯-2,3,3,3-四氟丙烷（HCFC-244eb）。 将包括HCFC-244eb和HCFC-225的原料组合物与相转移催化剂存在的碱性水溶液接触，从HCFC-225ca产生CFO-1214ya，同时从HCFC-244eb产生HFO-1234yf。
• MANUFACTURING METHOD OF 1-CHLORO-2,3,3,3-TETRAFLUOROPROPENE
  申请人：ASAHI GLASS COMPANY, LIMITED

  公开号：US20180297918A1

  公开（公告）日：2018-10-18

  There is provided an economically advantageous manufacturing method capable of efficiently obtaining 1-chloro-2,3,3,3-tetrafluoropropene by using 1,2-dichloro-2,3,3,3-tetrafluoropropane as a raw material. A manufacturing method of 1-chloro-2,3,3,3-tetrafluoropropene is characterized in that it includes subjecting 1,2-dichloro-2,3,3,3-tetrafluoropropane to a dehydrochlorination reaction in a liquid phase in a presence of a base.

  提供了一种经济优势的制造方法，能够有效地利用1,2-二氯-2,3,3,3-四氟丙烷作为原料，高效地获得1-氯-2,3,3,3-四氟丙烯。1-氯-2,3,3,3-四氟丙烯的制造方法的特点在于，它包括在碱的存在下将1,2-二氯-2,3,3,3-四氟丙烷在液相中进行脱氯化反应。
• PREPARATION OF NORMORPHINANS
  申请人：Mallinckrodt LLC

  公开号：US20150141649A1

  公开（公告）日：2015-05-21

  The present invention provides processes for preparing normorphinans from N-substituted morphinans. In particular, the invention provides methods for removing the N-substituent from the N-substituted morphinan to from a normorphinan carbamate, and then removing the carbamate functionality from the normorphinan carbamate to form the normorphinan.

  本发明提供了从N-取代吗啡内酯制备正吗啡内酯的方法。具体而言，本发明提供了从N-取代吗啡内酯中去除N-取代基，形成正吗啡内酯羰酸酯的方法，然后去除正吗啡内酯羰酸酯中的羰酸酯功能团，形成正吗啡内酯的方法。
• [EN] SOLID FORM OF INTERMEDIATE OF TICAGRELOR<br/>[FR] FORME SOLIDE D'INTERMÉDIAIRE DE TICAGRELOR
  申请人：CIPLA LTD

  公开号：WO2016030704A1

  公开（公告）日：2016-03-03

  A process for the preparation of a solid form of a compound of formula (VII) (Formula (VII)) comprises coupling(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine (R)-Mandelic acid of Formula (VI) with (2-[[(3a R,4S,6R,6aS)-6-[7-chloro-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-2,2- dimethyltetrahydro-3aH-cyclopenta[d[[1,3]dioxol-4-yl]oxy]-1-ethanol) of formula (V) in the presence of a suitable base and a first a suitable solvent at a suitable temperature to form 2- [[(3aR,4S,6R,6aS)-6-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3- triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]oxy]-1- ethanol of formula (VI)I; and isolating the compound of formula (VII) using a second suitable solvent so as to produce the compound of formula (VII) in solid form. A process for preparing Ticagrelor of formula (I) or a salt thereof (Formula (I)) comprises the conversion of a compound of formula (VII) in a solid form either as free base or as an acid addition salts thereof, into a compound of formula (I).

  一种制备化合物(VII)的固体形式的方法包括将(1R,2S)-2-(3,4-二氟苯基)环丙胺(R)-苯甲酸化合物(VI)与式(V)中的(2-[[(3aR,4S,6R,6aS)-6-[7-氯-5-(丙硫基)-3H-1,2,3-三唑并[4,5-d]嘧啶-3-基]-2,2-二甲基四氢-3aH-环戊[d][1,3]二氧杂环戊-4-基]氧基)-1-乙醇在适当碱和第一适当溶剂的存在下，在适当温度下偶联，形成式(VI)的2-[[（3aR,4S,6R,6aS）-6-[7-[[(1R,2S)-2-(3,4-二氟苯基)环丙基]氨基]-5-(丙硫基)-3H-1,2,3-三唑并[4,5-d]嘧啶-3-基]-2,2-二甲基四氢-3aH-环戊[d][1,3]二氧杂环戊-4-基]氧基]-1-乙醇；并使用第二适当溶剂分离化合物(VII)，以制备化合物(VII)的固体形式。一种制备式(I)的Ticagrelor或其盐（式(I)）的方法包括将化合物(VII)的固体形式（作为游离碱或其酸盐）转化为式(I)的化合物。
• Aminopyrrolidine platinum compounds, a process for preparing them and pharmaceutical compositions containing them
  申请人：FERRER INTERNACIONAL, S.A.

  公开号：EP0517225A1

  公开（公告）日：1992-12-09

  The present invention provides compounds of the formula by treatment of a potassium tetrachloroplatinite solution in water with the corresponding aminopyrrolidine. In the compounds of the present invention R is a linear alkyl group containing 1 to 12 carbon atoms and R₁ is a linear alkyl group containing 1 to 3 carbon atoms. The compounds of the present invention have pharmacological application due to their antitumor activity.

  本发明提供了一种通过在水中处理四氯合铂酸钾溶液与相应的氨基吡咯烷得到的公式化合物。在本发明的化合物中，R是含有1至12个碳原子的直链烷基基团，R₁是含有1至3个碳原子的直链烷基基团。由于其抗肿瘤活性，本发明的化合物具有药理应用。