Di-n-pentylphosphinsaeurechlorid | 1604-65-5

• 分子结构分类: 有机化合物 - 有机磷化合物
• 英文名称: Di-n-pentylphosphinsaeurechlorid
• 英文别名: dipentyl-phosphinoyl chloride；1-[Chloro(pentyl)phosphoryl]pentane
• CAS: 1604-65-5
• 化学式: C₁₀H₂₂ClOP
• 分子量: 224.711
• InChiKey: HQQITMKPAXRKMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Di-n-pentylphosphinsaeurechlorid 以61%的产率得到
  参考文献：
  名称：

  STREPIXEEV YU. A.; KOLESOVA V. A.; SHCHERBAKOVA G. I.; BALKUNOVA V. P., ZH. OBSHCH. XIMII, 1979, 49, HO 3, 596-600

  摘要：

  DOI：
• 作为产物：
  描述：

  dipentylphosphinic acid 在 三氯化磷 作用下， 生成 Di-n-pentylphosphinsaeurechlorid
  参考文献：
  名称：

  Christen; van der Linde, Recueil des Travaux Chimiques des Pays-Bas, 1959, vol. 78, p. 543,546

  摘要：

  DOI：

文献信息

• beta-DIHYDROFURAN DERIVING COMPOUND, METHOD FOR PRODUCING beta-DIHYDROFURAN DERIVING COMPOUND OR beta-TETRAHYDROFURAN DERIVING COMPOUND, beta-GLYCOSIDE COMPOUND, METHOD FOR PRODUCING beta GLYCOSIDE COMPOUND, AND METHOD FOR PRODUCING 4'-ETHYNYL D4T AND ANALOGUE COMPOUNDS THEREOF
  申请人：Iriyama Yusuke

  公开号：US20120322995A1

  公开（公告）日：2012-12-20

  The invention provides a process for producing a β-dihydrofuran derivative represented by formula (1) or a β-tetrahydrofuran derivative represented by formula (4), characterized in that the process includes causing a dialkyl dicarbonate, a diaralkyl dicarbonate, or a halide to act on a diol compound represented by formula (2) or (3). The invention also provides a process for producing 4′-ethynyl-2′,3′-didehydro-3′-deoxythymidine or an analog thereof, the process including glycosylation and deprotection.

  该发明提供了一种生产由式（1）表示的β-二氢呋喃衍生物或由式（4）表示的β-四氢呋喃衍生物的过程，其特征在于该过程包括使二烷基二碳酸酯、二芳基二碳酸酯或卤化物作用于由式（2）或（3）表示的二醇化合物。该发明还提供了一种生产4'-乙炔基-2',3'-二去氢-3'-脱氧胸苷或其类似物的过程，包括糖基化和去保护。
• Stabilized thyroxine compounds
  申请人：New River Pharmaceuticals Inc.

  公开号：US20040116391A1

  公开（公告）日：2004-06-17

  Throxinyldimethylphosphinate was invented as a prodrug to stabilize thyroxine, a drug widely used to treat hypothyroidism and depression. The presence of the dimethylphosphinate group at the phenolic hydroxyl of thyroxine is key to preventing thyroxine from decomposing through the proposed pathway. The prodrug will be hydrolyzed in the stomach or the gut into thyroxine and the biologically inert dimethylphosphinic acid. Related products may be stabilized with the same or similar protecting groups.

  Throxinyldimethylphosphinate被发明为一种前药，用于稳定甲状腺素，这是一种广泛用于治疗甲状腺功能减退症和抑郁症的药物。在甲状腺素的酚羟基上存在二甲基磷酸酯基团是防止甲状腺素通过提出的途径分解的关键。这种前药将在胃或肠中水解成甲状腺素和生物惰性的二甲基磷酸。相关产品可以使用相同或类似的保护基团来稳定。
• Chiral unsymmetric diphosphine compounds and transition metal complexes containing them as ligands
  申请人：Takasago International Corporation

  公开号：EP0754696A1

  公开（公告）日：1997-01-22

  Novel chiral unsymmetric diphosphine compounds, represented by formula (I) : wherein Ar1 and Ar2, which are different from each other, each represent a substituted or unsubstituted phenyl group, a substituted or unsubstituted naphthyl group, a pyridyl group, a quinolyl group, an isoquinolyl group, a furfuryl group, a benzofurfuryl group, a thienyl group, or a benzothienyl group. Transition metal complexes containing diphosphine compounds as ligands, where the complex catalyzes various asymmetric synthesis reactions, e.g., asymmetric hydrogenation or asymmetric hydrosilylation, exhibiting excellent performance in selectivity, conversion and catalytic activity, to provide a product of desired absolute configuration at high optical purity and in high yield.

  由式 (I) 表示的新型手性不对称二膦化合物： 其中彼此不同的 Ar1 和 Ar2 分别代表取代或未取代的苯基、取代或未取代的萘基、吡啶基、喹啉基、异喹啉基、糠基、苯并呋喃基、噻吩基或苯并噻吩基。 含有作为配体的二膦化合物的过渡金属配合物，该配合物可催化各种不对称合成反应，例如不对称氢化或不对称水硅烷化，在选择性、转化率和催化活性方面表现出优异的性能，以高光学纯度和高产率提供所需绝对构型的产物。
• Chiral diphosphine compound, intermediate for preparing the same, transition metal complex having the same diphosphine compound as ligand and asymmetric hydrogenation catalyst
  申请人：Takasago International Corporation

  公开号：EP0850945A1

  公开（公告）日：1998-07-01

  The present invention provides a novel diphosphine compound of the formula (I): where R1 and R2 represent independently cycloalkyl, unsubstituted or substituted phenyl, or five-membered heteroaromatic ring. The compound is useful as a ligand for an asymmetric reaction, in particular, asymmetric hydrogenation catalyst.

  本发明提供了一种新型的式 (I) 二膦化合物： 其中 R1 和 R2 独立地代表环烷基、未取代或取代苯基或五元杂芳环。该化合物可用作不对称反应的配体，特别是不对称氢化催化剂。
• B-DIHYDROFURAN DERIVING COMPOUND, METHOD FOR PRODUCING B-DIHYDROFURAN DERIVING COMPOUND OR B-TETRAHYDROFURAN DERIVING COMPOUND, B -GLYCOSIDE COMPOUND, METHOD FOR PRODUCING B-GLYCOSIDE COMPOUND, AND METHOD FOR PRODUCING 4'-ETHYNYL D4T AND ANALOGUE COMPOUNDS THEREOF
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP2537839A1

  公开（公告）日：2012-12-26

  The invention provides a process for producing a β-dihydrofuran derivative represented by formula (1) or a β-tetrahydrofuran derivative represented by formula (4), characterized in that the process includes causing a dialkyl dicarbonate, a diaralkyl dicarbonate, or a halide to act on a diol compound represented by formula (2) or (3). The invention also provides a process for producing 4'-ethynyl-2',3'-didehydro-3'-deoxythymidine or an analog thereof, the process including glycosylation and deprotection.

  本发明提供了一种生产由式(1)表示的β-二氢呋喃衍生物或由式(4)表示的β-四氢呋喃衍生物的工艺，其特征在于该工艺包括使二烷基二碳酸酯、二烷基二碳酸酯或卤化物作用于由式(2)或(3)表示的二元醇化合物。本发明还提供了一种生产 4'-乙炔基-2',3'-二脱氢-3'-脱氧胸苷或其类似物的工艺，该工艺包括糖基化和脱保护。