Phosphorsaeure-bis-<2-phenyl-ethylester> | 31735-80-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: Phosphorsaeure-bis-<2-phenyl-ethylester>
• 英文别名: Bis(2-phenylethyl) hydrogen phosphate
• CAS: 31735-80-5
• 化学式: C₁₆H₁₉O₄P
• 分子量: 306.298
• InChiKey: SFTQWOMFTCAKMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  sodium bis(phenethyl) phosphate 在 盐酸 作用下， 以 水 为溶剂， 生成 Phosphorsaeure-bis-<2-phenyl-ethylester>
  参考文献：
  名称：

  Phosphorous-containing cysteine and serine protease inhibitors

  摘要：

  本发明涉及一种新型含磷半胱氨酸或丝氨酸蛋白酶抑制剂。还描述了使用蛋白酶抑制剂的方法。

  公开号：

  US05639732A1

文献信息

• 5'-DIBENZYL PHOSPHATES OF 5-AZACYTIDINE OR 2'-DEOXY-5-AZACYTIDINE
  申请人：OHARA PHARMACEUTICAL CO., LTD.

  公开号：US20170152275A1

  公开（公告）日：2017-06-01

  The present invention relates to a novel compound represented by formula (1), or salt thereof, wherein R is hydroxy group or hydrogen atom; R 1 and R 2 are the same or different, and are each independently benzyl group which may have a substituent. The present invention provides therapeutically agents, which have remarkable stability against cytidine deaminase, a metabolic enzyme, can be absorbed in vivo by oral administration and inhibit protein synthesis by being incorporated easily into nucleic acid bio-synthesis in vivo for replacing injection agent (5-azacytidine or 2′-deoxy-5-azacytidine) used in clinic for treating myeloma.

  本发明涉及一种新型化合物，其式表示为（1），或其盐，其中R为羟基或氢原子；R1和R2相同或不同，且分别独立地为苄基，可以具有取代基。本发明提供了治疗剂，其对胞嘧啶脱氨酶具有显著的稳定性，可以通过口服在体内被吸收，并且通过容易地被纳入体内核酸生物合成中而抑制蛋白质合成，以替代在临床上用于治疗骨髓瘤的注射剂（5-氮杂胞苷或2'-脱氧-5-氮杂胞苷）。
• Traction drive fluid
  申请人：IDEMITSU KOSAN COMPANY LIMITED

  公开号：EP1057884A1

  公开（公告）日：2000-12-06

  There is disclosed a traction drive fluid which comprises a base oil blended with (A) an active phosphate ester base compound, (B) a boron-containing imide base dispersant (e.g. polyalkenyl succinimide treated with a boron compound ) and (C) a boron-free imide base dispersant (e.g. polyalkenyl succinimide) in such blending amounts that the phosphorus content derived from the component (A) and the boron content derived from the component (B) are each 100 to 600 ppm, preferably 60 to 300 ppm by weight, and at least 60 ppm by weight, respectively based on the base oil, and the boron-free imide base dispersant (C) is blended so that the ratio by weight of the nitrogen in the component (C) to the boron in the component (B) is at least 1, preferably 1 to 6. The traction drive fluid has excellent wear resistance and excellent scoring resistance of a steel material element, is capable of suppressing surface damage such as peeling of a friction material and in particular, is well suited for use as a lubricating oil for a traction drive continuous variable transmission used in an automobile.

  本发明公开了一种牵引传动液，它由基础油与 (A) 活性磷酸酯基化合物、(B) 含硼酰亚胺基分散剂（如用硼化合物处理过的聚烯基琥珀酰亚胺）和 (C) 无硼酰亚胺基分散剂（如聚烯基琥珀酰亚胺）混合而成，混合量为从组分 (A) 中提取的磷含量和从组分 (B) 中提取的硼含量各为 100 至 600 ppm，优选 60 至 600 ppm。(C) 无硼亚胺基分散剂（如聚烯基琥珀酰亚胺），其混合量为，以基础油为基准，由组分 (A) 产生的磷含量和由组分 (B) 产生的硼含量按重量计分别为 100 至 600 ppm，优选 60 至 300 ppm，以及至少 60 ppm，并且混合无硼亚胺基分散剂 (C)，使组分 (C) 中的氮与组分 (B) 中的硼的重量比至少为 1，优选 1 至 6。该牵引传动液具有优异的耐磨性和钢材料元件优异的抗划伤性，能够抑制表面损伤，如摩擦材料的剥落，特别适合用作汽车中使用的牵引传动无级变速器的润滑油。
• Lubricating oil composition for cellulose base wet friction material
  申请人：IDEMITSU KOSAN CO., LTD.

  公开号：EP1057882A1

  公开（公告）日：2000-12-06

  There is disclosed a lubricating oil composition for cellulose base wet friction material which comprises a base oil blended with (A) a boron-containing imide base dispersant (e.g. boron treated polyalkenyl succinimide) having a weight-average molecular weight in the range of 500 to 3000 and having a ratio by weight of boron to nitrogen (B/N) in the range of 0.1 to 1.5 in such a blending amount that the boron content and the nitrogen content each derived from the component (A) are made to be at least 60 ppm by weight and at least 100 ppm by weight, respectively based on the base oil. The above lubricating oil composition enhances peeling resistant durability for a friction material, especially a cellulose base friction material without impairing the wear resistance or scoring resistance of a steel material element, and is well suited for use in a cellulose base friction material for a starting and running device and a transmission clutch that are used in an automatic transmission of an automobile.

  本发明公开了一种用于纤维素基湿摩擦材料的润滑油组合物，该组合物包括一种基础油，其中掺有 (A) 一种含硼的酰亚胺基分散剂（例如硼处理过的聚烯基琥珀酰亚胺），其重量平均分子量在 500 至 3000 之间，硼与氮的重量比 (B/N) 在 0.1 至 1.5 的掺混量，使硼含量和氮含量分别至少为 60 ppm（重量）和 100 ppm（重量）（基于基础油）。上述润滑油组合物提高了摩擦材料，特别是纤维素基摩擦材料的抗剥落耐久性，而不会损害钢材料元件的耐磨性或抗划伤性，非常适合用于汽车自动变速器中的起动和运转装置及变速器离合器的纤维素基摩擦材料。
• Lubricant additive
  申请人：IDEMITSU KOSAN COMPANY LIMITED

  公开号：EP1142983A1

  公开（公告）日：2001-10-10

  A lubricant additive obtained by heating an acidic phosphate ester and/or a phosphite ester (A) represented by the general formula (I): (wherein A represents H or OH, m is 0 or 1, when m is 0, A is OH, and when m is 1, A is H or OH, R1 and R2 each independently represent H, or a hydrocarbon group having 1 to 18 carbon atoms that may contain at least one O and S, both R1 and R2 are not simultaneously hydrogen atoms) and an imide-based dispersant containing boron (B) at a temperature of 120 to 150°C for 5 hours or more, which can concurrently enhance excellent wear resistance, excellent scoring resistance and prolong surface fatigue life while keeping the balance of these properties at an optimum level.

  一种润滑油添加剂，通过加热通式(I)代表的酸性磷酸酯和/或亚磷酸酯(A)获得： (其中 A 代表 H 或 OH，m 为 0 或 1，当 m 为 0 时，A 为 OH，当 m 为 1 时，A 为 H 或 OH，R1 和 R2 各自独立地代表 H 或具有 1 至 18 个碳原子的烃基，其中可包含至少一个 O 和 S、R1 和 R2 不同时为氢原子）和含硼（B）的酰亚胺基分散剂，在 120 至 150°C 的温度下搅拌 5 小时或更长时间，可同时增强优异的耐磨性、优异的抗划伤性和延长表面疲劳寿命，同时将这些性能的平衡保持在最佳水平。
• LUBRICATING OIL ADDITIVE AND LUBRICATING OIL COMPOSITION
  申请人：IDEMITSU KOSAN CO., LTD.

  公开号：EP1686168A1

  公开（公告）日：2006-08-02

  The present invention is directed to a lubricating oil additive containing a reaction product of a succinimide compound and a phosphorus atom-containing compound, and to a lubricating oil composition containing a mineral oil and/or a synthetic base oil, and the above lubricating oil additive.

  本发明涉及一种含有琥珀酰亚胺化合物和含磷原子化合物反应产物的润滑油添加剂，以及一种含有矿物油和/或合成基础油以及上述润滑油添加剂的润滑油组合物。