Aluminium lithium tetrahydroxide | 94277-65-3

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 后过渡金属氧阴离子化合物
• 英文名称: Aluminium lithium tetrahydroxide
• 英文别名: aluminum;lithium;tetrahydroxide
• CAS: 94277-65-3
• 化学式: AlH₄O₄*Li
• 分子量: 101.952
• InChiKey: VMWZRHGIAVCFNS-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  -4.08
• 重原子数：
  6
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  4
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Aluminium lithium tetrahydroxide 在 lithium hydride 作用下， 以 neat (no solvent) 为溶剂， 生成 lithium aluminate
  参考文献：
  名称：

  Sasnovskaya, V. D.; Sinel'nikov, S. M.; Rosolovskii, V. Ya., Russian Journal of Inorganic Chemistry, 1986, vol. 31, p. 16 - 19

  摘要：

  DOI：
• 作为产物：
  描述：

  lithium aluminium tetrahydride 在 lithium hydroxide 作用下， 以 neat (no solvent) 为溶剂， 生成 Aluminium lithium tetrahydroxide
  参考文献：
  名称：

  Sasnovskaya, V. D.; Sinel'nikov, S. M.; Rosolovskii, V. Ya., Russian Journal of Inorganic Chemistry, 1986, vol. 31, p. 16 - 19

  摘要：

  DOI：

文献信息

• 4-Oxoquinolizine antimicrobial having 2-pyridone skeleton as partial structure
  申请人：SATO PHARMACEUTICAL CO., LTD.

  公开号：US20020173517A1

  公开（公告）日：2002-11-21

  A compound represented by the following Formula (I) or a pharmaceutically acceptable salt thereof: 1 wherein R 1 represents a hydrogen atom or a carboxyl-protecting group, R 2 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or a hydroxyl group, R 3 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a nitro group, a cyano group, a hydroxyl group or an amino group; R 4 represents a hydrogen atom, an amino-protecting group, an alkyl group or a cycloalkyl group, and R 5 represents a hydrogen atom, a halogen atom, an alkyl group, an alkenyl group, a cycloalkyl group, an aryl group, an alkoxy group, an alkylthio group, a hydroxyl group, an imino group or an amino group.

  以下为化合物式（I）或其药学上可接受的盐： 其中， R1代表氢原子或羧基保护基； R2代表氢原子、卤素原子、低碳基、低氧基或羟基； R3代表氢原子、卤素原子、低碳基、低氧基、低硫基、硝基、氰基、羟基或氨基； R4代表氢原子、氨基保护基、烷基或环烷基； R5代表氢原子、卤素原子、烷基、烯基、环烷基、芳基、氧基、硫基、羟基、亚氨基或氨基。
• Benzo[b,f]thiepin derivatives and process for producing the same
  申请人：Nippon Chemiphar Co., Ltd.

  公开号：US04166127A1

  公开（公告）日：1979-08-28

  Novel benzo [b,f] thiepin derivatives possessing strong anti-flammatory action and presenting few adverse reactions, of the formula (I) ##STR1## wherein R represents a fluorine atom, or a trifluoromethyl or 1-5C lower alkoxy group, and R.sub.3 and R.sub.4 each represent a 1-4C lower alkyl group or R.sub.3 and R.sub.4 together with the adjacent nitrogen atom to which they are attached form a heterocyclic group. Pharmaceutical compositions comprising an anti-inflammatory effective amount of the compound according to formula (I) in the presence of an inert carrier.

  具有强烈抗炎作用且副作用较少的新型苯并[b,f]噻吩衍生物，化学式如下（I）：##STR1## 其中，R代表氟原子，或三氟甲基或1-5C低烷氧基团；R.sub.3和R.sub.4分别代表1-4C低烷基团，或R.sub.3和R.sub.4与它们所连接的相邻氮原子形成杂环基团。制备一种药物组合物，该组合物包含一定量的化合物（I），以及惰性载体。
• Benzo[b,f]thiepan derivitives
  申请人：Nippon Chemiphar Company, Limited

  公开号：US04228284A1

  公开（公告）日：1980-10-14

  9-(.beta.-hydroxyethyl) piperazinyl-carbonyl-2-trifluoromethyl-10, 11-dihydrodibenzo[b,f]thiepin is prepared and disclosed as having antiinflamatory action.

  9-(β-羟乙基)哌嗪基-羰基-2-三氟甲基-10,11-二氢二苯并[b,f]噻吩被制备并披露为具有抗炎作用。
• Quinclidine derivatives as squalene synthase inhibitors
  申请人：Zeneca Limited

  公开号：US05691349A1

  公开（公告）日：1997-11-25

  Quinuclidine derivatives of formula, and their pharmaceutically acceptable salts, in which: R.sup.1 is hydrogen or hydroxy; R.sup.2 is hydrogen; pr R.sup.1 and R.sup.2 are joined together so that CR.sup.1 -CR.sup.2 is a double bond; X is selected from --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --C.dbd.C--, --CH.sub.2 O--, --OCH.sub.2 --, --CH.sub.2 NH--, NHCH.sub.2 --, --CH.sub.2 CO--, --COCH.sub.2 --, --CH.sub.2 S(O).sub.n -- and --S(O).sub.n CH.sub.2 -- wherein n is 0, 1 or 2; and AR is phenyl which may be optionally unsubstituted or substituted by one or more substituents such as halogeno, hydroxy, amino, nitro, cyano, carboxy, carbamoyl, alkyl, alkenyl, alkynyl, alkoxy, alkylamino, dialkylamino, N-alkylcarbamoyl, N,N-di-alkylcarbamoyl, alkoxycarbonyl, alkythio, alkylsulphinyl, alkylsulphonyl, halogeno alkyl, alkanoylamino, alkylenedioxy, alkanoyl and oxime derivatives thereof and O-alkyl ethers of said oximes; provided that when X is selected from --OCH.sub.2 --, --NHCH.sub.2 --, and SCH.sub.2 --, R.sup.1 is not hydroxy; inhibit squalene synthase and are useful in treating diseases or medical conditions in which inhibition of squalene synthase is desirable. The use of such heterocyclic derivatives in treating conditions such as hypercholesterolemia, and atherosclerosis is referred to as well as novel compounds, processes for their preparation and pharmaceutical compositions containing them.

  该配方中的喹诺啉衍生物及其药学上可接受的盐，其中：R.sup.1为氢或羟基；R.sup.2为氢；或者R.sup.1和R.sup.2相结合，使得CR.sup.1-CR.sup.2为双键；X从--CH.sub.2 CH.sub.2 --、--CH.dbd.CH--、--C.dbd.C--、--CH.sub.2 O--、--OCH.sub.2 --、--CH.sub.2 NH--、NHCH.sub.2 --、--CH.sub.2 CO--、--COCH.sub.2 --、--CH.sub.2 S(O).sub.n--和--S(O).sub.n CH.sub.2--中选择，其中n为0、1或2；AR为苯基，可以选择不取代或取代为一个或多个取代基，例如卤素、羟基、氨基、硝基、氰基、羧基、氨基甲酰、烷基、烯基、炔基、烷氧基、烷基氨基、二烷基氨基、N-烷基氨基甲酰、N,N-二烷基氨基甲酰、烷氧羰基、烷硫基、烷基磺酰基、卤素烷基、烷酰胺基、烷二氧基、烷酰基以及其氧吡啶衍生物和其O-烷基醚；但是当X从--OCH.sub.2 --、--NHCH.sub.2 --和SCH.sub.2 --中选择时，R.sup.1不是羟基；这些化合物抑制角鲨烯合酶并且在治疗需要抑制角鲨烯合酶的疾病或医疗情况中是有用的。这些杂环衍生物在治疗高胆固醇血症和动脉硬化等情况中的使用也被提到，以及新的化合物、其制备方法和含有它们的药物组成物。
• Benzo[b,f]thiepin derivatives
  申请人：Nippon Chemiphar Co., Ltd.

  公开号：US04101667A1

  公开（公告）日：1978-07-18

  Dihydrodibenzo[b,f]thiepin compounds of formula (I) and process for making them. These compounds have antiinflammatory action. ##STR1## wherein R represents a hydrogen, fluorine atom, a trifluoromethyl, 1-5C lower alkoxy, hydroxy, hydroxyethoxy, aminoethoxy group or the group of the formula --OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OH, Y represents a hydroxy group or the group of the formula ##STR2## (R.sub.3 and R.sub.4 represent a 1-4C lower alkyl group or R.sub.3 and R.sub.4 may jointly form a heterocyclic group together with an adjacent nitrogen atom.

  公式（I）的二氢二苯并[b，f]硫杓化合物及其制备方法。这些化合物具有抗炎作用。其中R代表氢，氟原子，三氟甲基，1-5C较低烷氧基，羟基，羟乙氧基，氨乙氧基或公式--OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OH的基团，Y代表羟基或公式##STR2##（R.sub.3和R.sub.4代表1-4C较低烷基或R.sub.3和R.sub.4可以与相邻的氮原子一起形成杂环基团。