(4R)-2-hydroxy-2-oxo-2λ⁵-[1,3,2]dioxaphospholane-4-carboxylic acid | 108801-06-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: (4R)-2-hydroxy-2-oxo-2λ⁵-[1,3,2]dioxaphospholane-4-carboxylic acid
• 英文别名: (4R)-2-Hydroxy-2-oxo-2λ⁵-[1,3,2]dioxaphospholan-4-carbonsaeure；(4R)-2-hydroxy-2-oxo-1,3,2lambda5-dioxaphospholane-4-carboxylic acid；(4R)-2-hydroxy-2-oxo-1,3,2λ5-dioxaphospholane-4-carboxylic acid
• CAS: 108801-06-5
• 化学式: C₃H₅O₆P
• 分子量: 168.043
• InChiKey: NIKBQFYQVLGFGA-UWTATZPHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 吡啶 、 N,N'-二环己基碳二亚胺 作用下， 生成 (4R)-2-hydroxy-2-oxo-2λ⁵-[1,3,2]dioxaphospholane-4-carboxylic acid
  参考文献：
  名称：

  The use of the Liverpool University neuroleptic side‐effect rating scale (LUNSERS) in clinical practice

  摘要：

  ABSTRACTForty‐four mental health clients completed the Liverpool University Neuroleptic Side‐Effect Rating Scale (LUNSERS)—a self‐rating scale to assess the prevalence and intensity of neuroleptic side‐effects. In the month prior to the study, 50% of the clients surveyed had experienced more than half of the side‐effects outlined on the 41‐item scale. A prevalence profile allowed us to rank the frequency of individual side‐effects across the sample. Some side‐effects such as ‘difficulty concentrating’, ‘difficulty remembering’, ‘tiredness’ and ‘restlessness’ were experienced by most of the clients in the study while ‘unusual skin marks’, ‘difficulty passing water’, ‘rashes’ were experienced by a few. A prevalence profile may be a useful guide in developing strategies for managing side‐effects more effectively in small groups of clients. In addition, the use of the LUNSERS in clinical practice would enable case managers to establish baseline measures for individual clients and evaluate changes in medication and other non‐medical strategies for reducing unwanted side‐effects. The identification and assessment of antipsychotic side‐effects is an important area for client and professional carer education.

  DOI：

  10.1046/j.1440-0979.2000.00181.x

文献信息

• 726. The hydrolysis of D-carboxyethylene phosphate (D-glyceric acid 2,3-cyclic phosphate)
  作者：R. F. Webb、A. J. Duke

  DOI：10.1039/jr9590003627

  日期：——