pentasodium;[oxido(phosphonatooxy)phosphoryl] phosphate

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱金属含氧阴离子化合物
• 英文名称: pentasodium;[oxido(phosphonatooxy)phosphoryl] phosphate
• 化学式: Na5O10P3
• 分子量: 367.86
• InChiKey: HWGNBUXHKFFFIH-UHFFFAOYSA-I

计算性质

• 辛醇/水分配系数(LogP)：
  -18.83
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  185
• 氢给体数：
  0
• 氢受体数：
  10

ADMET

代谢

被认为是水解成（正）磷酸盐后才能被吸收。/三聚磷酸盐/

THOUGHT TO BE HYDROLYZED TO (ORTHO)PHOSPHATES BEFORE ABSORPTION. /TRIPOLYPHOSPHATE/

来源:Hazardous Substances Data Bank (HSDB)

代谢

在体内，磷被转化为磷酸盐。

In the body, phosphorus is converted to phosphates. /Phosphorus/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 毒性总结

鉴定和使用：五钠三聚磷酸盐是一种白色粉末，可溶于水。它被用作过氧化氢稳定剂。这种化学物质是最广泛使用且在重负荷布料洗涤剂中最有效的助剂之一。由于其具有高的螯合能力，它还广泛应用于自动洗碗洗涤剂中。它形成稳定的螯合物，并有助于制造脆性的喷雾干燥洗衣粉。它用于乳制品替代品：牛奶布丁、搅打奶油、酸奶油和奶酪。它用于软化水以及作为悬浮剂；作为乳化剂和分散剂，它是控制油井中泥浆粘度的钻井流体清洁剂成分；还用作防腐剂、螯合剂，以及在食品中作为质地改良剂。这种有效成分不再包含在美国使用的任何注册杀虫剂产品中。人类暴露和毒性：如果大量摄入，这种化学物质可能导致恶心、呕吐和腹泻。当应用于人类的完整和磨损皮肤时，它会产生水泡。作为软化水的六钠磷酸盐、多磷酸盐、三聚磷酸盐、焦磷酸盐和其他磷酸盐会与钙形成复合物，并在摄入后能够严重降低血清中的离子钙水平。它们对粘膜的腐蚀作用小于钠或钾氢氧化物。与浓缩材料接触眼睛可能导致结膜水肿和角膜破坏。慢性皮炎可能发生在化学物质从包装材料迁移到食物后的重复接触。职业暴露涉及醋酸纤维素制造商、青铜合金制造商、弹药工人、烟雾弹和燃烧弹制造商、杀虫剂鼠药工人、肥料制造商、电致发光涂层制造商和半导体工人。动物研究：这种化学物质在小狗中诱导了呕吐。在动物中的饮食给药导致了骨骼、肝脏和脾脏的铁含量减少，以及骨骼中钙的耗尽。

IDENTIFICATION AND USE: Pentasodium tripolyphosphate is a white powder which is soluble in water.r It is used as a hydrogen peroxide stabilizer. This chemical is one of the most widely used and most effective builder in heavy duty fabric washing compositions. Because of its high sequestration power, it also finds extensive application in automatic dish washing detergents. It forms stable hydrates and aids in the manufacture of crisp spray dried laundry powders. It is used in dairy substitute products: milk based pudding, whipped topping, sour cream, and cheese. It is used in water softening and as a peptizing agent; emulsifier and dispersing agent, it is an ingredient of cleansers in drilling fluids to control mud viscosity in oil fields; as preservative, sequestrant, and as a texturizer in foods. The active ingredient is no longer contained in any registered pesticide products used in the United States. HUMAN EXPOSURE AND TOXICITY: If ingested in large amounts this chemical can cause nausea, vomiting, and diarrhea. It has produced vesiculation when applied to intact and abraded skin of humans. Sodium and potassium hexametaphosphates, polyphosphates, tripolyphosphates, pyrophosphates, and other phosphates used as water softeners form complexes with calcium and, after ingestion, are capable of seriously reducing the serum level of ionic calcium. They have less corrosive effect on mucous membranes than sodium or potassium hydroxide. Eye contact with concentrated material can cause conjunctival edema and corneal destruction. Chronic dermatitis may follow repeated contact of the chemical that migrates to food from packaging materials. Occupational exposure involves acetyl cellulose makers, bronze alloy makers, munitions workers, smoke bomb and incendiary makers, pesticide rat poison worker, fertilizer makers, electroluminescent-coating makers, and semiconductor workers. ANIMAL STUDIES: This chemical induced emesis in dogs. Dietary administration in animals has caused decrease iron content in bone, liver, and spleen, and bone depletion of calcium.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 暴露途径

该物质可以通过吸入其气溶胶被吸收进入人体。

The substance can be absorbed into the body by inhalation of its aerosol.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 吸入症状

咳嗽。喉咙痛。

Cough. Sore throat.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 皮肤症状

红斑。疼痛。

Redness. Pain.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 眼睛症状

红斑。疼痛。

Redness. Pain.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

吸收、分配和排泄

如果大量摄入，可能会出现恶心、呕吐和腹泻。据认为在吸收前会被水解成（正）磷酸盐。如果消化道吸收了大量完整的聚合物，由于与离子钙的结合（螯合），可能会导致低钙血症性手足搐搦症。在一个摄入事件中显然发生了低钙血症性手足搐搦症。/三聚磷酸盐/

If ingested in large amounts nausea, vomiting and diarrhea are probable. Thought to be hydrolyzed to (ortho)phosphates before absorption. If appreciable amounts of the intact polymer are absorbed from the alimentary tract, hypocalcemic tetany may be a danger due to the binding (chelation) of ionized calcium. Hypocalcemic tetany apparently occurred in one ingestion episode. /Tripolyphosphate/

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  pentasodium;[oxido(phosphonatooxy)phosphoryl] phosphate 以 水 为溶剂， 反应 1.0h， 生成 六水合三聚磷酸钠
  参考文献：
  名称：

  Preparation of granular sodium tripolyphosphate hexahydrate with low

  摘要：

  筛选出的无水三聚磷酸钠颗粒，含有至少2重量％的碱金属焦磷酸盐，优选为焦磷酸钠，使用理论水量的约145％至185％进行加湿，将无水三聚磷酸钠转化为六水合物形式。在加湿过程中搅拌材料以保持温度低于约80℃，并在低于80℃的温度下干燥加湿材料以去除大部分自由水。从干燥步骤中回收的产品是一种具有0.59 g / cc至0.64 g / cc范围内的堆积密度和不高于30％的易碎性的颗粒状的六水合物三聚磷酸钠产品。

  公开号：

  US04315898A1
• 作为产物：
  描述：

  、 六偏磷酸钠 、 四磷酸六钠盐 生成 pentasodium;[oxido(phosphonatooxy)phosphoryl] phosphate
  参考文献：
  名称：

  Agent for increasing the keeping quality of slaughtered-animal carcasses

  摘要：

  本发明涉及一种用于提高宰杀动物的体、宰杀动物的身体部位和汉堡肉饼的保鲜剂，其使用方法以及按照该方法保存的宰杀动物的体、宰杀动物的身体部位和汉堡肉饼。

  公开号：

  US05989611A1

文献信息

• Process for preparing medium density granular sodium tripolyphosphate
  申请人：FMC Corporation

  公开号：US03932590A1

  公开（公告）日：1976-01-13

  Finely divided sodium tripolyphosphate (STPP) particles are sprayed with a solution of sodium orthophosphate to prepare an agglomerated feed material which is then calcined at 300.degree. to 600.degree.C to produce granular STPP of medium range bulk density.

  细分的三聚磷酸钠（STPP）颗粒被喷洒一种正磷酸钠溶液，制备成一种凝聚的原料，然后在300℃至600℃的温度下煅烧，以生产中等范围的STPP颗粒。
• Compression process for multiphase tablets
  申请人：——

  公开号：US20010025020A1

  公开（公告）日：2001-09-27

  A compression process is provided for producing multiphase tablets, especially laundry detergent or cleaning product tablets, which comprises the steps of a) producing core tablets comprising active substance, b) optionally inserting one or more core tablets from step a) into a die of a tableting press, c) filling at least one particulate premix into the die of the tableting press, d) supplying at least one core tablet from step a) into the die of the tableting press, e) optional single or multiple repetition of steps c) and/or d), f) carrying out compression to give tablets, it being possible, if desired, to conduct steps c) and d) in the opposite order.

  提供一种压缩工艺，用于生产多相片剂，特别是洗涤剂或清洁产品片剂，其包括以下步骤：a）制备包含活性物质的核心片剂，b）可选地将步骤a）中的一个或多个核心片剂插入压片机模具中，c）向压片机模具中填充至少一个颗粒预混料，d）向压片机模具中提供至少一个来自步骤a）的核心片剂，e）可选地单次或多次重复步骤c）和/或d），f）进行压缩以得到片剂，如果需要，可以按相反的顺序进行步骤c）和d）。
• Washing, rinsing or cleaning products in portions in flexible water-soluble containers
  申请人：——

  公开号：US20040219297A1

  公开（公告）日：2004-11-04

  A portioned washing, rinsing, or cleaning product, wherein a preparation is surrounded by an enclosure. The unfilled enclosure is deformable by a force F 1 >0 N and ≦500 N along a path s 1 and, after the force has ceased, returns in the direction of its original shape with a recovery rate v>0 mm/min and ≦1000 mm/min. Also, a process for preparing the portioned product by injection molding, extrusion blowing, or thermoforming.

  这是一种分装的洗涤、漂洗或清洁产品，其中一种制剂被包裹在一个封闭的容器中。未填充的容器可以通过力F1>0 N和≤500 N沿路径s1变形，并在力停止后以恢复速率v>0 mm/min和≤1000 mm/min的方向返回其原始形状。此外，还提供了一种通过注塑成型、挤出吹塑或热成型制备分装产品的方法。
• Agent and device and method for producing the same
  申请人：——

  公开号：US20040224873A1

  公开（公告）日：2004-11-11

  A particulate detergent or cleaning product in the form of a direct spray drying product that has an apparent weight in the range from 220 g/l to 500 g/l and a particle diameter d50 in the range from 0.12 mm to 0.6 mm. Also, a method of producing the particulate product using a spray drying apparatus.

  一种颗粒洗涤剂或清洁产品，采用直接喷雾干燥工艺制成，表观密度在220 g/l至500 g/l范围内，粒径d50在0.12 mm至0.6 mm范围内。同时，还提供了一种使用喷雾干燥设备生产颗粒产品的方法。
• Method for producing nucleoside-5'-phosphate ester
  申请人：——

  公开号：US20020004590A1

  公开（公告）日：2002-01-10

  A method for producing nucleoside-5′-phosphate esters inexpensively and in high yields by phosphorylating a nucleoside with a phospahte group donor using an acid phosphatase having an increased affinity for the nucleoside and/or an increased temperature stability at a pH of pH 3.0 to 5.5, to produce a nucleoside-5′-phosphate ester. Mutant acid phosphatases having increased affinty for nucleosides and/or an enhanced temperature stability are also provided.

  一种制备核苷酸5'-磷酸酯的方法，通过使用具有对核苷酸增加亲和力和/或在pH 3.0至5.5的条件下具有增强温度稳定性的酸性磷酸酶，用磷酸供体对核苷酸进行磷酸化，以低成本高产率地制备核苷酸5'-磷酸酯。还提供了具有增强核苷酸亲和力和/或增强温度稳定性的突变酸性磷酸酶。