3-methylthiopropionyl chloride | 1263280-12-1

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 硫代碳卤化物
• 英文名称: 3-methylthiopropionyl chloride
• 英文别名: n-thiobutyryl chloride；ethyl thioacetyl chloride；Butanecarbothioyl chloride；butanethioyl chloride
• CAS: 1263280-12-1
• 化学式: C₄H₇ClS
• 分子量: 122.619
• InChiKey: NSXKVMCVAPWBAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  6
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  32.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  二甲胺 、 3-methylthiopropionyl chloride 以 苯 为溶剂， 生成 N,N-dimethylbutanethioamide
  参考文献：
  名称：

  Selective Reductions. V. The Partial Reduction of Tertiary Amides by Lithium Di- and Triethoxyaluminohydrides-A New Aldehyde Synthesis via the Dimethylamides

  摘要：

  DOI：

  10.1021/ja01060a025

文献信息

• 1,3-BENZOTHIAZINONE DERIVATIVES AND USE THEREOF
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1424336A1

  公开（公告）日：2004-06-02

  This invention provides a compound represented by the formula (I) : wherein R1 is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino optionally having substituents; R2 is pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each of which may have substituents; n is 1 or 2; or a salt. And this invention provides a safe pharmaceutical comprising the compound of the formula (I) , which has an excellent apoptosis inhibitory effect and MIF binding effect, for preventing and/or treating heart disease, nervous degenerative disease, cerebrovascular disease, central nervous infectious disease, traumatorathy, demyelinating disease, bone and articular disease, kidney disease, liver disease, osteomyelodysplasia, AIDS, cancer, and the like.

  这项发明提供了一种由以下式（I）表示的化合物： 其中R1是氢原子、卤素原子、羟基、硝基、可选择具有卤素取代基的烷基、可选择具有取代基的烷氧基、酰基或氨基； R2是吡啶基、呋喃基、噻吩基、吡咯基、喹啉基、吡嗪基、嘧啶基、吡啶并嘧啶基、吲哚基、四氢喹啉基或噻唑基，每种基团可能具有取代基； n为1或2；或其盐。该发明提供了一种安全的药物，包括具有优异的凋亡抑制作用和MIF结合作用的式（I）化合物，用于预防和/或治疗心脏病、神经退行性疾病、脑血管疾病、中枢神经感染性疾病、创伤病变、脱髓鞘疾病、骨骼和关节疾病、肾脏疾病、肝脏疾病、骨髓发育不良、艾滋病、癌症等。
• [EN] PIPERAZINE, [1,4]DIAZEPANE, [1,4]DIAZOCANE, AND [1,5]DIAZOCANE FUSED IMIDAZO RING COMPOUNDS<br/>[FR] COMPOSES DE CYCLES ACCOLES IMIDAZO DE PIPERAZINE, [1,4]DIAZEPANE, [1,4]DIAZOCANE, ET [1,5]DIAZOCANE
  申请人：3M INNOVATIVE PROPERTIES CO

  公开号：WO2005066172A1

  公开（公告）日：2005-07-21

  Piperazine, [1,4]diazepane, [1,4]diazocane, and [1,5]diazocane fused imidazo ring compounds (i.e., imidazoquinolines, tetrahydroimidazoquinolines, imidazonaphthyridines, tetrahydroimidazonaphthyridines, and imidazopyridines), pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

  哌嗪、[1,4]二氮杂环庚烷、[1,4]二氮杂环庚烷和[1,5]二氮杂环庚烷融合的咪唑环化合物（即咪唑喹啉、四氢咪唑喹啉、咪唑萘啉、四氢咪唑萘啉和咪唑吡啶），含有这些化合物的药物组合物，中间体，制备方法以及将这些化合物用作免疫调节剂的方法，用于诱导或抑制动物体内的细胞因子生物合成，并用于治疗包括病毒性和肿瘤性疾病在内的疾病。
• Nitro(tetrahydro-2H-1,3-thiazin-2-ylidene)methyl aldehydes and ketones
  申请人：Shell Oil Company

  公开号：US03962225A1

  公开（公告）日：1976-06-08

  Novel insecticidal nitro(tetrahydro-2H-1,3-thiazin-2-ylidene)methyl aldehydes and ketones.

  新型杀虫剂硝基（四氢-2H-1,3-噻唑-2-基亚甲基）醛和酮。
• Tetrapeptide amides
  申请人：Reckitt & Colman Products Limited

  公开号：US04199568A1

  公开（公告）日：1980-04-22

  Tetrapeptide amides of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, A and B represent certain specified substituent groups and where n is 2-5, p is 1-5 and r is 1 or 2. The compounds exhibit pharmacological activity when tested in the transmurally stimulating guinea pig ileum preparation indicating their affinity for opiate receptor sites and they may therefore be used in man for those conditions where an opiate-like effect is indicated.

  公式为## STR1##的四肽酰胺，其中R.sup.1、R.sup.2、R.sup.3、A和B代表某些指定的取代基，n为2-5，p为1-5，r为1或2。当在经皮刺激豚鼠回肠制备中进行测试时，这些化合物表现出药理活性，表明它们对阿片受体位点具有亲和力，因此它们可以用于那些需要阿片样效应的情况。
• Antifogging compounds and their use in silver halide photography
  申请人：AGFA-GEVAERT, N.V.

  公开号：US04451555A1

  公开（公告）日：1984-05-29

  The present invention deals with novel antifogging compounds and their use in a method of photographic reproduction comprising developing a photographic material having at least one exposed silver halide emulsion layer in the presence of a 1-phenyl-5-mercaptotetrazole compound wherein the phenyl group bears a substituent comprising at least one thioether function.

  本发明涉及新型防雾化合物及其在摄影再现方法中的应用，包括在1-苯基-5-巯基四唑化合物存在下，对至少一个暴露的银卤化物乳液层进行摄影材料的显影，其中苯基基团带有至少一个硫醚功能的取代基。