短青藤次碱 | 18145-26-1

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 尖防己碱及相关生物碱
• 中文名称: 短青藤次碱
• 英文名称: acutumidine
• 英文别名: (1S,4'S,6S,10R,11S)-11-chloro-4'-hydroxy-3',4,5-trimethoxyspiro[7-azatricyclo[4.3.3.01,6]dodec-4-ene-10,5'-cyclopent-2-ene]-1',3-dione
• CAS: 18145-26-1
• 化学式: C₁₈H₂₂ClNO₆
• 分子量: 383.829
• InChiKey: SBALNGLYQFMKPR-NQTWQHAWSA-N

物化性质

• 熔点：
  239-241 °C (decomp)
• 沸点：
  693.1±55.0 °C(Predicted)
• 密度：
  1.43±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  94.1
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  短青藤次碱 在 偶氮二异丁腈 、 三正丁基氢锡 作用下， 以 甲苯 为溶剂， 反应 3.0h， 以15 mg的产率得到dechloroacutumidine
  参考文献：
  名称：

  Alkaloids from Menispermum dauricum

  摘要：

  The alkaloids, dechloroacutumidine and 1-epidechloroacutumine, together with three known alkaloids, acutumidine, acutumine, and dechloroacutumine, were isolated from the rhizomes of Menispermum dauricum and their structures established by spectral and chemical methods. The cytotoxicity of each compound against the growth of human cell lines was studied, and acutumine selectively inhibited T-cell growth. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0031-9422(02)00162-0

文献信息

• Alkaloids from Menispermum dauricum
  作者：Bing-Wu Yu、Jian-Yong Chen、Yan-Ping Wang、Kin-Fai Cheng、Xiao-Yu Li、Guo-Wei Qin

  DOI：10.1016/s0031-9422(02)00162-0

  日期：2002.10

  The alkaloids, dechloroacutumidine and 1-epidechloroacutumine, together with three known alkaloids, acutumidine, acutumine, and dechloroacutumine, were isolated from the rhizomes of Menispermum dauricum and their structures established by spectral and chemical methods. The cytotoxicity of each compound against the growth of human cell lines was studied, and acutumine selectively inhibited T-cell growth. (C) 2002 Elsevier Science Ltd. All rights reserved.