Silver;(4-nitrophenyl) phosphate | 51952-77-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: Silver;(4-nitrophenyl) phosphate
• CAS: 51952-77-3
• 化学式: 2Ag*C₆H₄NO₆P
• 分子量: 432.811
• InChiKey: XJRQCEWDDGQPPK-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  118
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Silver;(4-nitrophenyl) phosphate 、 2,3,4,6-四-O-乙酰基-1-溴-Alpha-D-甘露糖 以 甲苯 为溶剂， 反应 18.0h， 生成 [(2R,3R,4S,5S,6R)-3,4,5-triacetyloxy-6-[(4-nitrophenoxy)-[(2R,3S,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxyphosphoryl]oxyoxan-2-yl]methyl acetate
  参考文献：
  名称：

  Mono, di and tri-mannopyranosyl phosphates as mannose-1-phosphate prodrugs for potential CDG-Ia therapy

  摘要：

  An efficient and convergent method for the synthesis of mannose-1-phosphate prodrugs is described as a potential therapy for congenital disorders of glycosylation-la (CDG-Ia). The key feature of the proposed approach is the silver assisted nucleophilic substitution of 2,3,4,6-tetra-O-protected-alpha-D-mannopyranosyl bromides with various silver phosphate salts to afford mono, di, and tri-mannopyranosyl phosphates. A preliminary biological evaluation of the synthesized phosphate prodrugs has been carried out. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.09.074

文献信息

• Studies on Pyrophosphates II. A New Method for the Synthesis of Nucleotide Coenzymes and Their Analogs
  作者：Iwao Nakagawa、Tsujiaki Hata

  DOI：10.1246/bcsj.46.3275

  日期：1973.10

  A new method for the synthesis of unsymmetrical pyrophosphates from the reaction of alkyl phosphorothioates and disilver salt of alkyl phosphates are described. Nucleotide coenzymes such as uridine diphosphate glucose, uridine diphosphate galactose, and flavin adenine dinucleotide was synthesized.

  描述了一种从硫代磷酸烷基酯和磷酸烷基酯的二银盐反应合成不对称焦磷酸盐的新方法。合成了核苷酸辅酶如尿苷二磷酸葡萄糖、尿苷二磷酸半乳糖和黄素腺嘌呤二核苷酸。
• Mono, di and tri-mannopyranosyl phosphates as mannose-1-phosphate prodrugs for potential CDG-Ia therapy
  作者：Renaud Hardré、Amira Khaled、Alexandra Willemetz、Thierry Dupré、Stuart Moore、Christine Gravier-Pelletier、Yves Le Merrer

  DOI：10.1016/j.bmcl.2006.09.074

  日期：2007.1

  An efficient and convergent method for the synthesis of mannose-1-phosphate prodrugs is described as a potential therapy for congenital disorders of glycosylation-la (CDG-Ia). The key feature of the proposed approach is the silver assisted nucleophilic substitution of 2,3,4,6-tetra-O-protected-alpha-D-mannopyranosyl bromides with various silver phosphate salts to afford mono, di, and tri-mannopyranosyl phosphates. A preliminary biological evaluation of the synthesized phosphate prodrugs has been carried out. (c) 2006 Elsevier Ltd. All rights reserved.