2-heptyl-1-methyl-4,5-dihydro-1H-imidazole | 117814-89-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 亚胺内酰胺
• 英文名称: 2-heptyl-1-methyl-4,5-dihydro-1H-imidazole
• 英文别名: 2-Heptyl-1-methyl-4,5-dihydro-1H-imidazol；1-Methyl-2-heptyl-2-imidazoline；2-heptyl-1-methyl-4,5-dihydroimidazole
• CAS: 117814-89-8
• 化学式: C₁₁H₂₂N₂
• 分子量: 182.309
• InChiKey: NFTHHHNYDXPVHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  15.6
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-heptyl-1-methyl-4,5-dihydro-1H-imidazole 在 petroleum 、 镍 作用下， 生成 2-heptyl-1-methyl-1H-imidazole
  参考文献：
  名称：

  取代的咪唑和2-咪唑啉。

  摘要：

  DOI：

  10.1021/jo01168a015
• 作为产物：
  描述：

  2-n-heptylimidazoline 生成 2-heptyl-1-methyl-4,5-dihydro-1H-imidazole
  参考文献：
  名称：

  取代的咪唑和2-咪唑啉。

  摘要：

  DOI：

  10.1021/jo01168a015

文献信息

• Compositions and method comprising heterocyclic compounds containing two
  申请人：——

  公开号：US05030629A1

  公开（公告）日：1991-07-09

  A method and compositions for enhancing absorption of topically administered physiologically active agents through the skin and mucous membranes of humans and animals in a transdermal device or formulation for local or systemic use, comprising a therapeutically effective amount of a pharmaceutically active agent and a non-toxic, effective amount of penetration enhancing agent of the formula I: ##STR1## wherein R is a saturated or unsaturated, straight or branched, cyclic or acyclic hydrocarbon group with from 1 to 19 carbon atoms, alkoxyalkyl, haloalkyl, specifically trifluoromethyl, alkoxy, amino, alkylamino and acylamino; R' and R" are hydrogen, alkyl, trifluoromethyl, alkoxyalkyl, aminoalkyl, alkyl- and acylaminoalkyl, carboxy, carbalkoxy, hydroxyalkyl or lower alkyl ester thereof; X is O or NR.sub.1 wherein R.sub.1 is hydrogen, alkyl, alkenyl, alkoxyalkyl, carbalkoxyalkyl, aminoalkyl, alkyl- and acylaminoalkyl, hydroxyalkyl or hydroxyalkyloxyalkyl and lower alkyl ester thereof; and n is 2 or 3 are disclosed.

  一种用于增强人类和动物皮肤和黏膜对经皮设备或制剂中局部或全身使用的局部应用生理活性药物的吸收的方法和组合物，包括治疗有效量的药用活性剂和公式I的非毒性、有效量的渗透增强剂：##STR1## 其中R是具有1至19个碳原子的饱和或不饱和、直链或支链、环状或非环状的烃基，烷氧基烷基，卤代烷基，特别是三氟甲基，烷氧基，氨基，烷基氨基和酰氨基；R'和R"是氢，烷基，三氟甲基，烷氧基烷基，氨基烷基，烷基和酰氨基烷基，羧基，羧酸烷氧基，羟基烷基或其较低烷基酯；X是O或NR.sub.1，其中R.sub.1是氢，烷基，烯烃基，烷氧基烷基，羧酸烷氧基烷基，氨基烷基，烷基和酰氨基烷基，羟基烷基或羟基烷氧基烷基及其较低烷基酯；n为2或3。
• CROSS-LINKABLE NITRILE RUBBER COMPOSITION AND CROSS-LINKED RUBBER
  申请人：Ikeda Shinya

  公开号：US20100256294A1

  公开（公告）日：2010-10-07

  A cross-linkable nitrile rubber composition containing a highly saturated nitrile rubber (a) having an α,β-ethylenically unsaturated nitrile monomer unit and a carboxyl-group containing monomer unit and having an iodine value of 120 or less, a cross-linking agent (b), and a specific cyclic amidine and/or cyclic amidinium salt (c) is provided. Preferably, the cross-linking agent (b) is a polyamine-based cross-linking agent (d), and more preferably, the carboxyl-group containing monomer unit is an α,β-ethylenically unsaturated dicarboxylic acid monoester monomer unit.

  提供了一种可交联的丁腈橡胶组合物，其中包含高度饱和的丁腈橡胶（a），其具有α，β-乙烯基不饱和丙烯腈单体单元和含羧基单体单元，并且碘值小于或等于120，交联剂（b）和特定的环状酰胺和/或环状酰胺盐（c）。优选，交联剂（b）是基于多胺的交联剂（d），更优选，含羧基单体单元是α，β-乙烯基不饱和二羧酸单酯单体单元。
• CROSSLINKABLE NITRILE RUBBER COMPOSITION AND CROSSLINKED RUBBER
  申请人：Zeon Corporation

  公开号：EP2239297A1

  公开（公告）日：2010-10-13

  A cross-linkable nitrile rubber composition containing a highly saturated nitrile rubber (a) having an α,β-ethylenically unsaturated nitrile monomer unit and a carboxyl-group containing monomer unit and having an iodine value of 120 or less, a cross-linking agent (b), and a specific cyclic amidine and/or cyclic amidinium salt (c) is provided. Preferably, the cross-linking agent(b) is a polyamine-based cross-linking agent (d), and more preferably, the carboxyl-group containing monomer unit is an α,β-ethylenically unsaturated dicarboxylic acid monoester monomer unit.

  本发明提供了一种可交联丁腈橡胶组合物，该组合物含有高饱和度丁腈橡胶（a）（具有一个α，β-乙烯基不饱和丁腈单体单元和一个含羧基的单体单元，且碘值在 120 或以下）、交联剂（b）以及特定的环状脒和/或环状脒盐（c）。优选地，交联剂（b）是聚胺基交联剂（d），更优选地，含羧基的单体单元是α，β-乙烯基不饱和二羧酸单酯单体单元。
• NITRILE RUBBER COMPOSITION AND RUBBER CROSS-LINKED PRODUCT
  申请人：Zeon Corporation

  公开号：EP2781547A1

  公开（公告）日：2014-09-24

  A nitrile rubber composition containing a carboxyl group-containing nitrile rubber and an allylamine-based polymer which contains units expressed by the following general formula (1) is provided. (In the general formula (1), R1, R2, and R3 respectively independently are one selected from a group comprised of a hydrogen atom, alkyl group containing 1 to 4 carbon atoms which may have substituents, aryl group containing 6 to 12 carbon atoms which may have substituents, and halogen atom.)

  本发明提供了一种丁腈橡胶组合物，该组合物含有含羧基的丁腈橡胶和烯丙基胺基聚合物，后者含有下式（1）表示的单元。 (通式(1)中，R1、R2 和 R3 分别独立地选自由氢原子、含 1 至 4 个碳原子且可带有取代基的烷基、含 6 至 12 个碳原子且可带有取代基的芳基和卤素原子组成的基团中的一个)。
• CROSSLINKABLE RUBBER COMPOSITION AND CROSSLINKED RUBBER
  申请人：Zeon Corporation

  公开号：EP2902437A1

  公开（公告）日：2015-08-05

  A cross-linkable rubber composition containing a carboxyl group-containing nitrile rubber (A) with an iodine value of 120 or less, a polyamine cross-linking agent (B), and a specific basic cross-linking accelerator (C) is provided. The basic cross-linking accelerator (C) is preferably dicyclopentylamine or dicyclohexylamine.

  提供了一种可交联橡胶组合物，其中包含碘值在 120 或以下的含羧基丁腈橡胶（A）、多胺交联剂（B）和特定的碱性交联促进剂（C）。碱性交联促进剂（C）最好是二环戊胺或二环己胺。