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    首页 分子通 2-chloromethyl-3,5,7,8-tetrahydro-pyrano[4,3-d]pyrimidin-4-one

    2-chloromethyl-3,5,7,8-tetrahydro-pyrano[4,3-d]pyrimidin-4-one | 1417917-59-9

    分子结构分类

    有机化合物 - 有机杂环化合物 - 吡喃嘧啶类
    中文名称
    ——
    中文别名
    ——
    英文名称
    2-chloromethyl-3,5,7,8-tetrahydro-pyrano[4,3-d]pyrimidin-4-one
    英文别名
    2-(Chloromethyl)-7,8-dihydro-3H-pyrano[4,3-D]pyrimidin-4(5H)-one；2-(chloromethyl)-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-4-one
    2-chloromethyl-3,5,7,8-tetrahydro-pyrano[4,3-d]pyrimidin-4-one化学式
    CAS
    1417917-59-9
    化学式
    C8H9ClN2O2
    mdl
    ——
    分子量
    200.625
    InChiKey
    RPZAUKYBUXOJNX-UHFFFAOYSA-N
    BEILSTEIN
    ——
    EINECS
    ——
    • 物化性质
    • 计算性质
    • ADMET
    • 安全信息
    • SDS
    • 制备方法与用途
    • 上下游信息
    • 反应信息
    • 文献信息
    • 表征谱图
    • 同类化合物
    • 相关功能分类
    • 相关结构分类

    物化性质

    • 沸点：
      350.3±52.0 °C(Predicted)
    • 密度：
      1.58±0.1 g/cm3(Predicted)

    计算性质

    • 辛醇/水分配系数(LogP)：
      -0.4
    • 重原子数：
      13
    • 可旋转键数：
      1
    • 环数：
      2.0
    • sp3杂化的碳原子比例：
      0.5
    • 拓扑面积：
      50.7
    • 氢给体数：
      1
    • 氢受体数：
      3

    上下游信息

    • 下游产品
      中文名称 英文名称 CAS号 化学式 分子量
      • 1
      • 2

    反应信息

    • 作为反应物：
      描述：
      2-chloromethyl-3,5,7,8-tetrahydro-pyrano[4,3-d]pyrimidin-4-one 在 sodium azide 作用下， 以 丙酮 为溶剂， 反应 36.0h， 以19.25 g的产率得到2-(azidomethyl)-7,8-dihydro-3H-pyrano[4,3-d]pyrimidin-4(5H)-one
      参考文献：
      名称：
      [EN] NOVEL 2-PIPERIDIN-1-YL-ACETAMIDE COMPOUNDS FOR USE AS TANKYRASE INHIBITORS
      [FR] NOUVEAUX COMPOSÉS 2-PIPERIDIN-1-YL-ACETAMIDE UTILISABLES EN TANT QU'INHIBITEURS DE TANKYRASE
      摘要：
      本发明提供了式(I)的化合物，其中R1-R5和L在此处定义。本发明还提供了包含式(I)化合物的药物组合物和组合物，以及将这些化合物用作坦基酶抑制剂以及用于治疗Wnt信号和坦基酶1和2信号相关疾病的用途，包括但不限于癌症。
      公开号：
      WO2013012723A1
    • 作为产物：
      描述：
      四氢吡喃酮 在 potassium tert-butylate 、 三乙胺 作用下， 以 甲醇 为溶剂， 反应 28.5h， 生成 2-chloromethyl-3,5,7,8-tetrahydro-pyrano[4,3-d]pyrimidin-4-one
      参考文献：
      名称：
      [EN] NOVEL 2-PIPERIDIN-1-YL-ACETAMIDE COMPOUNDS FOR USE AS TANKYRASE INHIBITORS
      [FR] NOUVEAUX COMPOSÉS 2-PIPERIDIN-1-YL-ACETAMIDE UTILISABLES EN TANT QU'INHIBITEURS DE TANKYRASE
      摘要：
      本发明提供了式(I)的化合物，其中R1-R5和L在此处定义。本发明还提供了包含式(I)化合物的药物组合物和组合物，以及将这些化合物用作坦基酶抑制剂以及用于治疗Wnt信号和坦基酶1和2信号相关疾病的用途，包括但不限于癌症。
      公开号：
      WO2013012723A1
    点击查看最新优质反应信息

    文献信息

    • [EN] NOVEL 2-PIPERIDIN-1-YL-ACETAMIDE COMPOUNDS FOR USE AS TANKYRASE INHIBITORS<br/>[FR] NOUVEAUX COMPOSÉS 2-PIPERIDIN-1-YL-ACETAMIDE UTILISABLES EN TANT QU'INHIBITEURS DE TANKYRASE
      申请人：NOVARTIS AG
      公开号：WO2013012723A1
      公开（公告）日：2013-01-24
      The present invention provides for compounds of formula (I), wherein R1-R5 and L are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.
      本发明提供了式(I)的化合物，其中R1-R5和L在此处定义。本发明还提供了包含式(I)化合物的药物组合物和组合物，以及将这些化合物用作坦基酶抑制剂以及用于治疗Wnt信号和坦基酶1和2信号相关疾病的用途，包括但不限于癌症。
    • [EN] 4-OXO-3,5,7,8-TETRAHYDRO-4H-PYRANO {4,3-D} PYRMINIDINYL COMPOUNDS FOR USE AS TANKYRASE INHIBITORS<br/>[FR] COMPOSÉS DE 4-OXO-3,5,7,8-TÉTRAHYDRO-4H-PYRANO{4,3-D}PYRIMINIDINYLE UTILISABLES À TITRE D'INHIBITEURS DE TANKYRASES
      申请人：NOVARTIS AG
      公开号：WO2013010092A1
      公开（公告）日：2013-01-17
      The present invention provides for compounds of formula (I) wherein R1 and R2 are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.
      本发明提供了以下式（I）中R1和R2被定义的化合物。本发明还提供了含有式（I）化合物的药物组合物和配方，以及将这些化合物用作坦基酶抑制剂以及用于治疗Wnt信号和坦基酶1和2信号相关疾病的用途，包括但不限于癌症。
    • 4-PIPERIDINYL COMPOUNDS FOR USE AS TANKYRASE INHIBITORS
      申请人：Chen Christine Hiu-Tung
      公开号：US20150126513A1
      公开（公告）日：2015-05-07
      The present invention provides for compounds of formula (I): wherein R 1 -R 4 and n are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.
      本发明提供了公式（I）的化合物：其中R1-R4和n在此定义。本发明还提供了包括公式（I）化合物的制药组合物和组合物，以及将这些化合物用作坦克酰酶抑制剂，并用于治疗与Wnt信号和坦克酰酶1和2信号相关的疾病，包括但不限于癌症。
    • NOVEL 2-PIPERIDIN-1-YL-ACETAMIDE COMPOUNDS FOR USE AS TANKYRASE INHIBITORS
      申请人：Cheung Atwood Kim
      公开号：US20150025070A1
      公开（公告）日：2015-01-22
      The present invention provides for compounds of formula (I): wherein R 1 -R 5 and L are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.
      本发明提供了公式（I）的化合物：其中R1-R5和L在此定义。本发明还提供了含有公式（I）化合物的药物组合物和组合物，以及将这些化合物用作坦克酶抑制剂和治疗与Wnt信号和坦克酶1和2信号相关的疾病的用途，包括但不限于癌症。
    • 4-piperidinyl compounds for use as tankyrase inhibitors
      申请人：Chen Christine Hiu-Tung
      公开号：US09163003B2
      公开（公告）日：2015-10-20
      The present invention provides for compounds of formula (I): wherein R1-R4 and n are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.
      本发明提供了式(I)的化合物：其中R1-R4和n在此定义。本发明还提供了包含式(I)化合物的药物组合物和组合物，以及将这些化合物用作坦克酶抑制剂和治疗与Wnt信号和坦克酶1和2信号相关的疾病的用途，包括但不限于癌症。
    查看更多

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