cyclohexyl methylphosphonamidate | 151575-92-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: cyclohexyl methylphosphonamidate
• 英文别名: [Amino(methyl)phosphoryl]oxycyclohexane
• CAS: 151575-92-7
• 化学式: C₇H₁₆NO₂P
• 分子量: 177.183
• InChiKey: RJMRRGPEUZANKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  亚硝基苯 、 cyclohexyl methylphosphonamidate 在 1,3-二溴-1,3,5-三嗪-2,4,6-三酮 作用下， 以 二氯甲烷 为溶剂， 以32%的产率得到
  参考文献：
  名称：

  Synthesis of N?-phosphinatodiazene N-oxides

  摘要：

  We have developed a regiospecific method for synthesis of N'-phosphinatodiazene N-oxides, a previously unknown type of azoxy compounds in which the diazene oxide fragment is directly connected with the phosphinate group. The method involves reaction of amidoesters of alkyl- and arylphosphonic acids with nitroso compounds in the presence of dibromoisocyanurate.

  DOI：

  10.1007/bf00863379
• 作为产物：
  描述：

  Methylphosphonsaeure-cyclohexylester-chlorid 在 氨 作用下， 以 乙醚 为溶剂， 反应 0.67h， 以31%的产率得到cyclohexyl methylphosphonamidate
  参考文献：
  名称：

  Synthesis of N?-phosphinatodiazene N-oxides

  摘要：

  We have developed a regiospecific method for synthesis of N'-phosphinatodiazene N-oxides, a previously unknown type of azoxy compounds in which the diazene oxide fragment is directly connected with the phosphinate group. The method involves reaction of amidoesters of alkyl- and arylphosphonic acids with nitroso compounds in the presence of dibromoisocyanurate.

  DOI：

  10.1007/bf00863379

文献信息

• Differentiation of chiral phosphorus enantiomers by 31P and 1H NMR spectroscopy using amino acid derivatives as chemical solvating agents
  作者：Yingchun Li、Frank M. Raushel

  DOI：10.1016/j.tetasy.2007.06.012

  日期：2007.7

  ability of commercially available amino acid derivatives, especially Fmoc-Trp(Boc)-OH, to differentiate enantiomers of chiral phosphonates, phosphinates, phosphates, phosphine oxides, and phosphonamidates is demonstrated with (31)P, (13)C, and (1)H NMR spectroscopy. The chiral differentiation provided a rapid and convenient method for measuring the enantiomeric purity of these phosphorus compounds.

  (31)P、(13)C 和1) H 核磁共振光谱。手性分化为测量这些磷化合物的对映体纯度提供了一种快速方便的方法。