Phosphoric acid (R)-2,3-dihydroxy-propyl ester 2-dimethylamino-ethyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: Phosphoric acid (R)-2,3-dihydroxy-propyl ester 2-dimethylamino-ethyl ester
• 英文别名: [(2R)-2,3-dihydroxypropyl] 2-(dimethylamino)ethyl hydrogen phosphate
• 化学式: C₇H₁₈NO₆P
• 分子量: 243.197
• InChiKey: KYLYEZUDQSQIRP-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.6
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  99.5
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  肉豆蔻酸 、 Phosphoric acid (R)-2,3-dihydroxy-propyl ester 2-dimethylamino-ethyl ester 在 2,4,6-三甲基苯磺酰氯 作用下， 以 氯仿 为溶剂， 反应 0.5h， 以76%的产率得到1,2-二肉豆蔻酰基甘油-3-磷脂酰-N,N-二甲基乙醇胺
  参考文献：
  名称：

  Misharin; Chernov, Russian Journal of Bioorganic Chemistry, 1997, vol. 23, # 8, p. 616 - 620

  摘要：

  DOI：

文献信息

• [EN] POLYUNSATURATED FATTY ACIDS FOR THE TREATMENT OF DISEASES RELATED TO CARDIOVASCULAR, METABOLIC AND INFLAMMATORY DISEASE AREAS<br/>[FR] ACIDES GRAS POLYINSATURÉS POUR LE TRAITEMENT DE MALADIES RELATIVES AU DOMAINE DES MALADIES CARDIOVASCULAIRES, MÉTABOLIQUES ET INFLAMMATOIRES.
  申请人：PRONOVA BIOPHARMA NORGE AS

  公开号：WO2010128401A9

  公开（公告）日：2011-12-08
• HUMANIZED ANTIBODY COMPOSITIONS AND METHODS FOR BINDING LYSOPHOSPHATIDIC ACID
  申请人：Lpath, Inc.

  公开号：US20140199293A1

  公开（公告）日：2014-07-17

  Compositions and methods for making and using humanized anti-LPA monoclonal antibodies, and fragments and derivatives thereof, are described.
• NOVEL BIOACTIVE LIPID DERIVATIVES, AND METHODS OF MAKING AND USING THE SAME
  申请人：LPATH, INC.

  公开号：US20150031055A1

  公开（公告）日：2015-01-29

  Compositions and methods for producing monoclonal antibodies and their derivatives reactive against bioactive lipid targets are described. These compositions include derivatized lipids, each of which comprises a bioactive lipid that having a polar head group and at least one hydrocarbon chain (e.g., a lysolipid such as lysophosphatidic acid or sphingosine-1-phosphate) in which a carbon atom has been derivatized with a pendant reactive group; immunogens made by linking a derivatized lipid to a carrier moiety (e.g., a carrier protein, polyethylene glycol, colloidal gold, alginate, or a silicone bead); monoclonal antibodies and derivatives produced by immunizing an animal with such an immunogen; and therapeutic and diagnostic compositions containing such antibodies and antibody derivatives. Methods for making such derivatized lipids, immunogens, and monoclonal antibodies and derivatives, methods for detecting such antibodies once generated, and therapeutic and diagnostic methods for using such antibodies and derivatives, are also described.
• COMPOSITIONS AND METHODS FOR BINDING LYSOPHOSPHATIDIC ACID
  申请人：SABBADINI Roger A.

  公开号：US20160152735A1

  公开（公告）日：2016-06-02

  Compositions and methods for making and using anti-LPA agents, for example, monoclonal antibodies, are described. Variable domain and complementarity determining region amino acid sequences of several monoclonal antibodies against LPA are disclosed, as is a consensus anti-LPA monoclonal antibody variable domain sequence.
• METHODS AND KITS FOR DETECTING AND DIAGNOSING NEUROTRAUMA
  申请人：SABBADINI Roger A.

  公开号：US20170254822A1

  公开（公告）日：2017-09-07

  Methods and kits for detecting and diagnosing neurotrauma (e.g., traumatic brain injury, stroke, or spinal cord injury) are provided. These methods rely on the determination of lysophosphatidic acid (LPA) and/or LPA metabolite levels in patient samples following suspected injury.