[EN] METAL/RADIOMETAL-LABELED PSMA INHIBITORS FOR PSMA-TARGETED IMAGING AND RADIOTHERAPY<br/>[FR] INHIBITEURS DU PSMA MARQUÉS PAR UN MÉTAL/RADIOMÉTAL POUR IMAGERIE ET RADIOTHÉRAPIE CIBLÉES VERS LE PSMA
申请人:UNIV JOHNS HOPKINS
公开号:WO2015171792A1
公开(公告)日:2015-11-12
Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA- specific Ti-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific Ti contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA- targeted imaging in vivo. 86Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics.
Synthesis and Coordination Chemistry of Phosphine Oxide Decorated Dibenzofuran Platforms
作者:Daniel Rosario-Amorin、Eileen N. Duesler、Robert T. Paine、Benjamin P. Hay、Lætitia H. Delmau、Sean D. Reilly、Andrew J. Gaunt、Brian L. Scott
DOI:10.1021/ic300301d
日期:2012.6.18
A four-step synthesis for 4,6-bis(diphenylphosphinoylmethyl)dibenzofuran (4) from dibenzofuran and a two-step synthesis for 4,6-bis(diphenylphosphinoyl)dibenzofuran (5) are reported along with coordination chemistry of 4 with In(III), La(III), Pr(III), Nd(III), Er(III), and Pu(IV) and of 5 with Er(III). Crystal structuredeterminations for the ligands, 4·CH3OH and 5, the 1:1 complexes [In(4)(NO3)3]
insufficient. Here, NO decomposition activity on several metal ion doped Ba3Y4O9 catalysts is reported and it is found that Cu is the most effective for increasing the activity. With 10% Cudoping, the catalytic activity and the stability were improved simultaneously. Temperature programmed desorption (TPD) results indicate that doping with Cu increased the amount of surface oxygen vacancies and mobility
氮氧化物(NO X)的直接分解是去除化学工业和汽车产生的NO X污染的理想方法。Ba 3 Y 4 O 9是用于NO X直接分解反应的有希望的候选物,但是,其催化活性不够高并且稳定性不足。在此,NO对几种掺杂金属离子的Ba 3 Y 4 O 9的分解活性据报道有催化剂,并且发现Cu对于增加活性最有效。掺杂10%的Cu可以同时提高催化活性和稳定性。程序升温解吸(TPD)结果表明,掺杂Cu会增加表面氧空位的数量和晶格氧的迁移率,从而导致NO吸附增加并促进NO X中间物种的分解。原位FT-IR光谱证明铜掺杂减弱NO的关联3 -物种,从而促进NO的分解3 -在低温下物种,这导致了对NO的高催化活性X分解。这些结果表明,将Cu引入Ba 3 Y 4 O 9体系是实现高活性的有效途径,并且是稳定的NO X直接分解催化剂。
H<sub>2</sub>Evolution from Aqueous Potassium Sulfite Solutions under Visible Light Irradiation over a Novel Sulfide Photocatalyst NaInS<sub>2</sub>with a Layered Structure
NaInS2 which consisted of anion layers of InS2− with a 2.3 eV band gap showed the photocatalytic activity for H2evolutionfrom an aqueous K2SO3 solution under visible light irradiation (λ>420 nm).
Enhanced photoelectric performance of Cu<sub>2−x</sub>Se nanostructure by doping with In<sup>3+</sup>
作者:Huanhuan Kou、Yimin Jiang、Jiajia Li、Shengjiao Yu、Chunming Wang
DOI:10.1039/c1jm14507j
日期:——
In3+ doped Cu2âxSe nanostructures have been successfully synthesized on a flexible carboxyl functionalized multi-walled carbon nanotubes/polyimide (COOH-MWCNTs/PI) membrane substrate by an electrochemical codeposition method. In this work, the focus was on the effect of different In3+ doping concentrations upon the morphological, structural, optical and photoelectrical properties of Cu2âxSe. Two different kinds of nanostructures, nanoflowers and nanolayers, were obtained. The crystallinity of Cu2âxSe was improved by doping with In3+. The atomic ratio of Cu, Se in Cu2âxSe nanolayers is about 1.85â:â1.00, and the atomic % of In is 1.32, confirming the presence of indium. The optical absorption intensity increased with an increase in the doping content of indium ions. However, In3+ had no effect upon the band gap and absorption edge. The effect of In3+ dopant on the photoelectric properties was investigated by photocurrentâtime and currentâvoltage (IâV) measurements, which demonstrated that the photoelectric properties of Cu2âxSe were improved by doping with In3+. This result is significant for the fabrication of optoelectronic nanomaterials and photodetectors based on In3+-doped Cu2âxSe nanoflowers and nanolayers.