[(2R,5R)-2-(methoxymethyl)-5-(5-methyl-4-oxo-2-sulfanylidenepyrimidin-1-yl)oxolan-3-yl] methyl hydrogen phosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核糖核苷3'-磷酸盐
• 英文名称: [(2R,5R)-2-(methoxymethyl)-5-(5-methyl-4-oxo-2-sulfanylidenepyrimidin-1-yl)oxolan-3-yl] methyl hydrogen phosphate
• 化学式: C₁₂H₁₉N₂O₇PS
• 分子量: 366.33
• InChiKey: FPYAUDZEVOGMCB-VXRWAFEHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  139
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• COMPOSITIONS AND METHODS FOR OPTIMIZING CLEAVAGE OF RNA BY RNASE H
  申请人：Isis Pharmaceuticals, Inc.

  公开号：US20150011001A1

  公开（公告）日：2015-01-08

  The present invention provides compositions and methods for the optimization of cleavage of RNA species by RNase H. In some embodiments, the invention provides oligonucleotides that possess two or more regions of differing conformation, and at least one transitional nucleobase positioned between the regions that is capable of modulating transfer of the helical conformation characteristic of the region bound to the 3′ hydroxy thereof, to the region bound to the 5′ hydroxyl thereof.
• US8790919B2
  申请人：——

  公开号：US8790919B2

  公开（公告）日：2014-07-29