(1R,5S)-10-oxa-3,9-diazatricyclo[3.3.1.11,4]decane-9-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: (1R,5S)-10-oxa-3,9-diazatricyclo[3.3.1.11,4]decane-9-carboxylic acid
• 化学式: C₈H₁₂N₂O₃
• 分子量: 184.19
• InChiKey: XTEMDAAKXBZONA-OHEWIBQUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  61.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• P2X7 MODULATORS
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2970287A1

  公开（公告）日：2016-01-20
• [EN] P2X7 MODULATORS<br/>[FR] MODULATEURS DE P2X7
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2014152621A1

  公开（公告）日：2014-09-25

  The present invention is directed to a compound of Formula (I): wherein: The present invention is directed to a compound of Formula (I): wherein: • n is an integer from 0-1; • X is CH2 when n is 0, or X is CH2 or oxygen when n is 1; • R 1is phenyl or pyridinyl, wherein the phenyl or pyridinyl is optionally substituted with from 1 to 4 substituents independently selected from halogen and alkyl; and • R 2isS phenyl, pyridinyl, pyrazinyl, pyradizinyl, pyrimidinyl, pyrrolyl, pyrazolyl, thiazolyl or thiophenyl, wherein the phenyl, pyridinyl, pyrazinyl, pyradizinyl, pyrimidinyl, pyrrolyl, pyrazolyl, thiazolyl or thiophenyl is optionally substituted with from 1 to 2 substituents independently selected from the group consisting of halogen, alkyl, hydroxy and alkoxy. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). The compounds of formula (I) are useful as P2X7 modulators.