N-羟基-N-(2-(膦酰氧基)乙基)-甲酰胺 | 126986-24-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 中文名称: N-羟基-N-(2-(膦酰氧基)乙基)-甲酰胺
• 英文名称: Fosfoxacin
• 英文别名: 2-[formyl(hydroxy)amino]ethyl dihydrogen phosphate
• CAS: 126986-24-1
• 化学式: C₃H₈NO₆P
• mdl: MFCD09837664
• 分子量: 185.073
• InChiKey: CTKGSLXEDHVOQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  phosphoric acid dibenzyl 2-(N-benzyloxy-N-formylamino)ethyl ester 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 20.0 ℃ 、101.32 kPa 条件下， 以91%的产率得到N-羟基-N-(2-(膦酰氧基)乙基)-甲酰胺
  参考文献：
  名称：

  Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-d-xylulose 5-phosphate reductoisomerase

  摘要：

  Analogs of the antibiotic fosmidomycin, an inhibitor of the methylerythritol phosphate pathway to isoprenoids, were synthesized and evaluated against the recombinant Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR). Fosfoxacin, the phosphate analog of fosmidomycin, and its acetyl congener were found to be more potent inhibitors of DXR than fosmidomycin. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.11.012

文献信息

• Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-d-xylulose 5-phosphate reductoisomerase
  作者：Youn-Hi Woo、Roberta P.M. Fernandes、Philip J. Proteau

  DOI：10.1016/j.bmc.2005.11.012

  日期：2006.4

  Analogs of the antibiotic fosmidomycin, an inhibitor of the methylerythritol phosphate pathway to isoprenoids, were synthesized and evaluated against the recombinant Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR). Fosfoxacin, the phosphate analog of fosmidomycin, and its acetyl congener were found to be more potent inhibitors of DXR than fosmidomycin. (c) 2005 Elsevier Ltd. All rights reserved.