[[5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [5-(3-azaniumylcarbonylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - （5'->5'）-二核苷酸
• 英文名称: [[5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [5-(3-azaniumylcarbonylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
• 英文别名: [[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [5-(3-azaniumylcarbonylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
• 化学式: C21H27N7O14P2
• 分子量: 663.4
• InChiKey: BAWFJGJZGIEFAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6
• 重原子数：
  44
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  321
• 氢给体数：
  7
• 氢受体数：
  18

文献信息

• Interference compensating two electrodes test strip
  申请人：Roche Diagnostics Operations, Inc.

  公开号：US10590458B2

  公开（公告）日：2020-03-17

  A method of detecting at least one analyte in a test sample is provided comprising a) contacting the test sample (i) to an active chemistry matrix changing at least one electrochemical property dependent on an enzymatic activity active in the presence of the analyte, the active chemistry matrix contacting a first electrode; and (ii) to an inactive chemistry matrix, the inactive chemistry matrix contacting a second electrode, b) closing an electrical circuit including the first electrode, the second electrode, and the active chemistry matrix and inactive chemistry matrix, followed by determining a first value of the at least one electrochemical property, c) inverting electrical polarity of the electrical circuit of b), followed by determining a second value of the at least one electrochemical property, and d) detecting the at least one analyte based on the first value and on the second value.

  本发明提供了一种检测测试样品中至少一种分析物的方法，包括 a) 将测试样品 (i) 与活性化学基质接触，改变至少一种依赖于分析物存在时活性酶活性的电化学性质，活性化学基质与第一电极接触；以及 (ii) 与非活性化学基质接触，非活性化学基质与第二电极接触；b) 闭合包括第一电极、第二电极、活性化学基质和非活性化学基质的电路；b) 闭合包括第一电极、第二电极、活性化学基质和非活性化学基质的电路，然后确定至少一种电化学性质的第一值， c) 反转 b) 电路的极性，然后确定至少一种电化学性质的第二值， d) 根据第一值和第二值检测至少一种分析物。
• Small molecule metabolites for the diagnosis of bacterial vaginosis and assessment of disease risk
  申请人：Fred Hutchinson Cancer Research Center

  公开号：US10690651B2

  公开（公告）日：2020-06-23

  The invention disclosed herein generally relates to methods and kits for diagnosing, assessing disease risk, treating, and preventing bacterial vaginosis (BV) and associated conditions. Additional embodiments include methods for developing metabolic profiles associated with increased disease risk, and developing new approaches to treat BV based on interrupting metabolic networks.

  本文公开的发明一般涉及诊断、评估疾病风险、治疗和预防细菌性阴道病（BV）及相关疾病的方法和试剂盒。其他实施方案包括开发与疾病风险增加相关的代谢图谱的方法，以及开发基于干扰代谢网络治疗 BV 的新方法。
• INTERFERENCE COMPENSATING TWO ELECTRODES TEST STRIP
  申请人：Roche Diagnostics GmbH

  公开号：EP3186385A2

  公开（公告）日：2017-07-05
• CANCER TREATMENT BY GLYCEROL-3-PHOSPHATE DEHYDROGENASE 1 INHIBITION
  申请人：Deutsches Krebsforschungszentrum Heidelberg Stiftung des öffentlichen Rechts (DKFZ)

  公开号：EP3541938A1

  公开（公告）日：2019-09-25
• Pathway Analysis of Cell Culture Phenotypes and Uses Thereof
  申请人：Melville Mark

  公开号：US20090186358A1

  公开（公告）日：2009-07-23

  The present invention provides methods for systematically identifying genes, proteins and/or related pathways that regulate or indicative of cell phenotypes. The present invention further provides methods for manipulating the identified genes, proteins and/or pathways to engineer improved cell lines and/or to evaluate or select cell lines with desirable phenotypes.

表征谱图