Lead (II) orthophosphate

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 后过渡金属氧阴离子化合物
• 英文名称: Lead (II) orthophosphate
• 英文别名: bis[(2-oxo-1,3,2λ5,4λ2-dioxaphosphaplumbetan-2-yl)oxy]lead
• 化学式: O8P2Pb3
• 分子量: 8.102
• InChiKey: HUTDDBSSHVOYJR-UHFFFAOYSA-H

计算性质

• 辛醇/水分配系数(LogP)：
  -6.79
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  173
• 氢给体数：
  0
• 氢受体数：
  8

ADMET

毒理性

• 致癌性证据

无机铅化合物的致癌性在人类中的证据有限。...在实验动物中，无机铅化合物的致癌性有足够的证据。在实验动物中，醋酸铅、次醋酸铅、铬酸铅和磷酸铅的致癌性有足够的证据。在实验动物中，氧化铅和砷酸铅的致癌性证据不足。...在实验动物中，铅粉的致癌性证据不足。总体评估无机铅化合物可能对人类具有致癌性（2A组）。/无机铅化合物/

There is limited evidence in humans for the carcinogenicity of inorganic lead compounds. ... There is sufficient evidence in experimental animals for the carcinogenicity of inorganic lead compounds. There is sufficient evidence in experimental animals for the carcinogenicity of lead acetate, lead subacetate, lead chromate, and lead phosphate. There is inadequate evidence in experimental animals for the carcinogenicity of lead oxide and lead arsenate. ... There is inadequate evidence in experimental animals for the carcinogenicity of lead powder. Overall evaluation Inorganic lead compounds are probably carcinogenic to humans (Group 2A). /Inorganic lead compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

分类：B2；可能的人类致癌物。分类依据：充分的动物证据。十项大鼠生物测试和一项小鼠测试显示，通过饮食和皮下接触几种可溶性铅盐，肾肿瘤统计学上显著增加。动物测试在多个实验室、多种大鼠品系中提供了可重复的结果，并有部分多肿瘤位点的证据。短期研究表明铅影响基因表达。人类致癌性数据不足。人类致癌性数据：不足。动物致癌性数据：充分。/基于以前分类系统的铅和化合物（无机）/

CLASSIFICATION: B2; probable human carcinogen. BASIS FOR CLASSIFICATION: Sufficient animal evidence. Ten rat bioassays and one mouse assay have shown statisticlly significant increases in renal tumors with dietary and subcutaneous exposure to several soluble lead salts. Animal assays provide reproducible results in several laboratories, in multiple rat strains with some evidence of multiple tumor sites. Short term studies show that lead affects gene expression. Human evidence is inadequate. HUMAN CARCINOGENICITY DATA: Inadequate. ANIMAL CARCINOGENICITY DATA: Sufficient. /Lead and Compounds (inorganic), Based on former classification system/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

A3; 对动物已确认是致癌物，但对人类的相关性未知。/铅，元素铅和无机铅化合物，如 Pb/

A3; Confirmed animal carcinogen with unknown relevance to humans. /Lead, elemental, and inorganic compounds, as Pb/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

铅、铅化合物：合理预期为人类致癌物

Lead, lead compounds: Reasonably anticipated to be a human carcinogen

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

神经毒素 - 主要影响运动功能 肾毒素 - 在职业环境中，这种化学物质可能对肾脏有毒。 溶血性贫血 - 血红蛋白或红细胞数量减少。 生殖毒素 - 对生殖系统有毒的化学物质，包括对后代缺陷以及损伤男性或女性生殖功能。生殖毒性包括发育效应。参见生殖毒性风险评估指南。 国际癌症研究机构（IARC）致癌物 - 2类：国际癌症研究机构将化学物质分类为可能的（2a）或潜在的（2b）人类致癌物。 美国国家毒理学项目（NTP）致癌物 - 有理由预期为人类致癌物。 美国工业卫生协会（ACGIH）致癌物 - 动物实验已确认。

Neurotoxin - Predominantly motor Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting. Hemolytic anemia - Decreased hemoglobin or number of red blood cells. Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment. IARC Carcinogen - Class 2: International Agency for Research on Cancer classifies chemicals as probable (2a), or possible (2b) human carcinogens. NTP Carcinogen - Reasonably anticipated to be a human carcinogen. ACGIH Carcinogen - Confirmed Animal.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases