disodium;dioxido(dioxo)tungsten

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱金属含氧阴离子化合物
• 英文名称: disodium;dioxido(dioxo)tungsten
• 化学式: Na2O4W
• 分子量: 293.82
• InChiKey: XMVONEAAOPAGAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.61
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80.3
• 氢给体数：
  0
• 氢受体数：
  4

ADMET

毒理性

• 相互作用

饲料中的钨酸在5 ppm浓度下可以减少哺乳动物中硒的有毒效果。/钨酸/

DIETARY TUNGSTATE AT 5 PPM REDUCES THE TOXIC EFFECTS OF SELENIUM IN MAMMALS. /TUNGSTATE/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，并在需要时辅助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，并在必要时进行治疗……。监测休克，并在必要时进行治疗……。预期癫痫发作，并在必要时进行治疗……。对于眼睛污染，立即用水冲洗眼睛。在转运过程中，用生理盐水连续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的干呕反射且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……。在去污后，用干燥的无菌敷料覆盖皮肤烧伤……。/毒药A和B/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

高级治疗：对于无意识、严重肺水肿或呼吸停止的患者，考虑进行口咽或鼻咽气管插管以控制气道。使用气囊面罩装置的正压通气技术可能有益。监测心率和必要时治疗心律失常... 开始静脉输液，使用D5W/SRP：“保持开放”，最低流量/。如果出现低血容量的迹象，使用乳酸钠林格液。注意液体过载的迹象。考虑使用药物治疗肺水肿... 对于伴有低血容量迹象的低血压，谨慎输液。注意液体过载的迹象... 用地西泮（安定）治疗癫痫... 使用丙美卡因氢氯化物协助眼部冲洗... /毒药A和B/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

年轻大鼠被喂食了70天，喂食了相当于2%体重的钨酸钠，这具有明显毒性，导致初始体重下降，所有动物在10天内死亡。在相当于0.5%体重的饮食中，四分之三的大鼠死亡。

...YOUNG RATS WERE FED FOR...70 DAYS...SODIUM TUNGSTATE EQUIV TO 2% W... MARKEDLY TOXIC, CAUSING INITIAL WT LOSS...DEATHS OF ALL ANIMALS...WITHIN 10 DAYS. IN DIETS HAVING EQUIV 0.5% W...DEATH IN 3/4 RATS.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

钨酸钠拮抗了钼作为黄嘌呤脱氢酶的金属载体在正常代谢作用中的角色。...饮食中加入的钨酸钠抑制了大鼠肠道中黄嘌呤氧化酶的沉积，并减少了...鸡肝中黄嘌呤脱氢酶和钼的浓度。

SODIUM TUNGSTATE ANTAGONIZES THE NORMAL METABOLIC ACTION OF MOLYBDATE IN ITS ROLE AS METAL CARRIER FOR XANTHINE DEHYDROGENASE. ...SODIUM TUNGSTATE ADDED TO DIET INHIBITED THE INTESTINAL DEPOSITION OF XANTHINE OXIDASE IN RAT & REDUCED...XANTHINE DEHYDROGENASE & MOLYBDENUM CONCN IN LIVER OF CHICKEN.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

实验鼠...喂食...100天控制饮食/包括钨酸钠/...主要沉积部位为骨骼和脾脏，肾和肝脏中有微量（小于1.0毫克%）含量，在一些动物中血液、肺、肌肉和睾丸中也有。

RATS...FED...100 DAYS ON DIETS /INCL SODIUM TUNGSTATE/... PRINCIPAL SITES OF DEPOSITION WERE BONE & SPLEEN WITH TRACE QUANTITIES (LESS THAN 1.0 MG %...) IN KIDNEY & LIVER, & IN SOME ANIMALS IN BLOOD, LUNG, MUSCLE & TESTES.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

口服硫酸钨后...一天后，脾脏中浓度最高，其次是肾脏、皮肤、骨骼和肝脏。...通过大鼠的胃管给药后...肾脏中浓度最高，其次是骨骼和脾脏。

...AFTER ORAL ADMIN OF SODIUM TUNGSTATE...AFTER 1 DAY, GREATEST CONCN IN SPLEEN FOLLOWED BY KIDNEY, PELT, BONE & LIVER. ...FOLLOWING ADMIN...BY GASTRIC INTUBATION IN RATS...HIGHEST CONCN IN KIDNEY FOLLOWED BY BONE & SPLEEN.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

大约一半的摄入剂量...的溶液盐...在动物模型中迅速吸收...大部分被吸收的钨...迅速通过尿液排出。少量的...保留部分从血浆转移到红细胞中，并主要分布到脾脏、肾脏和骨骼中。/溶液加盐/

ALMOST 1/2 OF INGESTED DOSE...OF A SOL SALT...RAPIDLY ABSORBED IN...ANIMAL MODELS... MOST OF ABSORBED TUNGSTEN...RAPIDLY EXCRETED IN URINE. SMALL AMT... RETAINED WAS TRANSFERRED IN PART FROM PLASMA TO RED BLOOD CELLS & DISTRIBUTED MAINLY TO SPLEEN, KIDNEY, & BONE. /SOL W SALT/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在2只比格犬中静脉注射钨酸钠（181）W后，发现大部分活性在最初的24小时内存在于血浆中，平均血浆与红细胞的比率约为3:1，这表明钨结合在细胞表面而不是穿透细胞膜。...建议钨并入红细胞发生在造血位点。

FOLLOWING IV ADMIN (181)W SODIUM TUNGSTATE IN 2 BEAGLE DOGS, MOST OF ACTIVITY WAS FOUND IN PLASMA DURING 1ST 24 HR, WITH AVG PLASMA TO RED CELL RATIO 3:1, SUGGESTING BINDING OF TUNGSTEN TO CELL SURFACE RATHER THAN PENETRATION OF CELL MEMBRANE. ...SUGGESTED THAT W INCORPORATION INTO RED CELLS OCCURS @ SITES OF HEMATOPOIESIS.

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  disodium;dioxido(dioxo)tungsten 生成 disodium;carbonate
  参考文献：
  名称：

  KAROV, Z. G.;AGNOKOV, T. SH.;XOCHUEV, I. YU.;KYAROV, A. A., TSV. MET.,(1989) N, S. 94-98

  摘要：

  DOI：
• 作为产物：
  描述：

  disodium;carbonate 生成 disodium;dioxido(dioxo)tungsten
  参考文献：
  名称：

  BORISOVA, N. A.;ZELIKMAN, A. N.;RAKOVA, N. N.;TOTIEV, V. A., 6 BCEC. SOVESHCH. PO XIMII I TEXNOL. MOLIBDENA I VOLFRAMA, NALCHIK, 13-15+

  摘要：

  DOI：
• 作为试剂：
  描述：

  2-[(2-ethoxyethyl)thio]-4-(pyridin-3-yl)thiazole 、 、 双氧水 、 碳酸氢钠 在 disodium;dioxido(dioxo)tungsten 氯仿 、 magnesium sulfate 、 silica gel 作用下， 以 溶剂黄146 、 水 为溶剂， 反应 4.0h， 以to obtain 0.27 g of white crystalline powders (77% yield)的产率得到2-((2-ethoxyethyl)sulfinyl)-4-(pyridin-3-yl)thiazole
  参考文献：
  名称：

  Thiazole and imidazole derivatives and antiulcer composition containing

  摘要：

  具有通式（I）的噻唑或咪唑衍生物：##STR1## 其中：R.sup.1和R.sup.2，可以相同或不同，各自独立地表示氢原子，苯基或杂环芳基，或者R.sup.1和R.sup.2可以共同形成苯环，该苯环可以选择性地由卤原子或选择性地由卤原子，较低的烷基，低的烷氧基或硝基取代; A表示硫原子或--NH--; B表示选择性地由卤原子取代的较低的烷氧基;一个含有一个氮或氧原子的五元或六元饱和杂环环，该环可以选择性地取代;一个含有一个氧原子加一个氮原子的六元饱和杂环环; 一个组--XR.sup.3，其中X表示一个组--NR.sup.4，其中R.sup.3和R.sup.4可以相同或不同，各自独立地表示较低的烷基;或一个组--NHC(.dbd.Y)R.sup.5，其中Y表示一个氧或硫原子或一个组.dbd.NCN或.dbd.CHNO.sub.2，R.sup.5表示一个组--NHR.sup.6或--SR.sup.6，其中R.sup.6表示一个选择性地由卤原子取代的较低的烷基;m是1到4的整数; n是0到2的整数;以及它们的药学上可接受的盐。这些化合物具有抗溃疡活性。

  公开号：

  US05171746A1

文献信息

• Autoclave tungstate upgrading of scheelite concentrates
  申请人：Amax Inc.

  公开号：US04313914A1

  公开（公告）日：1982-02-02

  A calcium tungstate concentrate is produced by slurrying an aqueous sodium tungstate liquor with calcium carbonate at about 130.degree. C. to about 200.degree. C. while providing sufficient carbon dioxide overpressure to convert sodium carbonate in the slurry to sodium bicarbonate, wherein the conversion of sodium tungstate to solid calcium tungstate in the slurry is promoted. The carbon dioxide is then stripped from the slurry, causing the sodium bicarbonate to convert to sodium carbonate, and a calcium tungstate concentrate is filtered from the slurry. The invention is useful in upgrading impure calcium tungstate concentrates.

  通过在约130°C至约200°C时，将水溶性钨酸钠液与碳酸钙混合悬浮，同时提供足够的二氧化碳过压以将混悬液中的碳酸钠转化为碳酸氢钠，从而促进钨酸钠向固态钨酸钙的转化，制备出一种钨酸钙浓缩物。然后从混悬液中去除二氧化碳，导致碳酸氢钠转化为碳酸钠，从混悬液中过滤出一种钨酸钙浓缩物。该发明可用于升级不纯的钨酸钙浓缩物。
• Analytical element for clinical analysis
  申请人：Eastman Kodak Company

  公开号：US04110079A1

  公开（公告）日：1978-08-29

  An analytical element for use in the clinical assay of an analyte contained in a biological liquid sample which is applied from an external source to a substantially planar sample receiving suface of the element. The analytical element comprises a porous layer bearing the aforementioned sample receiving surface; at least one dry reagent material for use in the assay; and one or more associated rupturable pod-like member(s) containing a liquid reagent for the assay, such liquid reagent, upon rupture of the pod-like member(s), being released into the element.

  一种分析元素，用于临床检测生物液体样品中的分析物，该样品从外部来源施加于元素的基本平面样品接收表面上。该分析元素包括一个多孔层，该多孔层承载上述样品接收表面；至少一种干燥试剂物质用于检测；以及一个或多个相关的可破裂的荚状成员，其中包含用于检测的液体试剂，当荚状成员破裂时，该液体试剂被释放到元素中。
• NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND METHOD FOR PRODUCING SAME
  申请人：Kutose Koichi

  公开号：US20130023664A1

  公开（公告）日：2013-01-24

  There are provided a nitrogen-containing heterocyclic compound such as a substituted amino-pyridine-N-oxide compound represented by formula (1), which is useful as a synthetic intermediate for an agrochemical and the like; and a method for producing the nitrogen-containing heterocyclic compound. (In formula (1), R 1 and R 2 each represents a hydrogen atom or an unsubstituted or substituted alkyl group; R 3 represents a hydrogen atom, an unsubstituted or substituted alkylcarbonyl group or the like; R 4 represents an unsubstituted or substituted alkylcarbonyl group, an unsubstituted or substituted arylcarbonyl group or the like; A represents a hydroxyl group, a thiol group or the like; m represents any one of integers of 1 to 4; k represents any one of integers of 0 to 3; and k+m≦4.)

  提供了一种含氮杂环化合物，例如由公式（1）表示的取代氨基吡啶-N-氧化物化合物，可用作农药等合成中间体；以及生产含氮杂环化合物的方法。（在公式（1）中，R1和R2分别表示氢原子或未取代或取代的烷基基团；R3表示氢原子、未取代或取代的烷基羰基基团或类似物；R4表示未取代或取代的烷基羰基基团、未取代或取代的芳基羰基基团或类似物；A表示羟基、硫醇基或类似物；m表示1至4的任意整数之一；k表示0至3的任意整数之一；且k+m≤4。）
• METHOD FOR PRODUCING AMMONIUM TUNGSTATE AQUEOUS SOLUTION
  申请人：Ito Hideaki

  公开号：US20120328506A1

  公开（公告）日：2012-12-27

  A method for producing an ammonium tungstate aqueous solution includes the steps of: adding sulfuric acid to a solution containing tungstate ions; bringing the solution having the sulfuric acid added therein, into contact with an anion exchange resin; and bringing the anion exchange resin into contact with an aqueous solution containing ammonium ions.

  生产铵钨酸水溶液的方法包括以下步骤：向含钨酸盐离子的溶液中加入硫酸；将加入硫酸的溶液与阴离子交换树脂接触；将阴离子交换树脂与含铵离子的水溶液接触。
• Nitrogen-containing heterocyclic compound and method for producing same
  申请人：Kutose Koichi

  公开号：US08703959B2

  公开（公告）日：2014-04-22

  There are provided a nitrogen-containing heterocyclic compound such as a substituted amino-pyridine-N-oxide compound represented by formula (1), which is useful as a synthetic intermediate for an agrochemical and the like; and a method for producing the nitrogen-containing heterocyclic compound. (In formula (1), R1 and R2 each represents a hydrogen atom or an unsubstituted or substituted alkyl group; R3 represents a hydrogen atom, an unsubstituted or substituted alkylcarbonyl group or the like; R4 represents an unsubstituted or substituted alkylcarbonyl group, an unsubstituted or substituted arylcarbonyl group or the like; A represents a hydroxyl group, a thiol group or the like; m represents any one of integers of 1 to 4; k represents any one of integers of 0 to 3; and k+m≦4.)

  提供了一种含氮杂环化合物，如式（1）所表示的取代氨基吡啶-N-氧化物化合物，它可用作农药等合成中间体；以及一种生产含氮杂环化合物的方法。（在式（1）中，R1和R2分别表示氢原子或未取代或取代的烷基；R3表示氢原子，未取代或取代的烷基羰基基团或类似物；R4表示未取代或取代的烷基羰基基团，未取代或取代的芳基羰基基团或类似物；A表示羟基，硫醇基或类似物；m表示1到4中的任意整数之一；k表示0到3中的任意整数之一；且k+m≤4。)