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    热门化合物HOT
    • 喹啉
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    • 谷胱甘肽
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    首页 分子通 1,4-dihydronicotinamide adenine dinucleotide

    1,4-dihydronicotinamide adenine dinucleotide

    分子结构分类

    有机化合物 - 核苷、核苷酸和类似物 - 吡啶核苷酸
    中文名称
    ——
    中文别名
    ——
    英文名称
    1,4-dihydronicotinamide adenine dinucleotide
    英文别名
    β NADH；[[(2R,3S,4R,5S)-5-(6-amino-7H-purin-8-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
    1,4-dihydronicotinamide adenine dinucleotide化学式
    CAS
    ——
    化学式
    C21H29N7O14P2
    mdl
    ——
    分子量
    665.447
    InChiKey
    ITHLNINGIUMTDS-VJOGCJHKSA-N
    BEILSTEIN
    ——
    EINECS
    ——
    • 物化性质
    • 计算性质
    • ADMET
    • 安全信息
    • SDS
    • 制备方法与用途
    • 上下游信息
    • 反应信息
    • 文献信息
    • 表征谱图
    • 同类化合物
    • 相关功能分类
    • 相关结构分类

    计算性质

    • 辛醇/水分配系数(LogP)：
      -5.9
    • 重原子数：
      44
    • 可旋转键数：
      11
    • 环数：
      5.0
    • sp3杂化的碳原子比例：
      0.52
    • 拓扑面积：
      329
    • 氢给体数：
      9
    • 氢受体数：
      19

    文献信息

    • STABILIZATION OF NADPH OR NADH IN AMMONIA DETECTION ASSAYS
      申请人：Roche Diagnostics GmbH
      公开号：EP3918087A1
      公开（公告）日：2021-12-08
    • Pathway Analysis of Cell Culture Phenotypes and Uses Thereof
      申请人：Melville Mark
      公开号：US20090186358A1
      公开（公告）日：2009-07-23
      The present invention provides methods for systematically identifying genes, proteins and/or related pathways that regulate or indicative of cell phenotypes. The present invention further provides methods for manipulating the identified genes, proteins and/or pathways to engineer improved cell lines and/or to evaluate or select cell lines with desirable phenotypes.
    • [EN] STABILIZATION OF NADPH OR NADH IN AMMONIA DETECTION ASSAYS<br/>[FR] STABILISATION DE NADPH OU NADH DANS DES DOSAGES DE DÉTECTION D'AMMONIAC
      申请人：ROCHE DIAGNOSTICS GMBH
      公开号：WO2020157178A1
      公开（公告）日：2020-08-06
      The present disclosure deals with the biochemistry of reagents useful in the detection of ammonia in liquid samples. Specifically, the present disclosure is directed to a technical improvement of an enzyme-based test for ammonia that can be used for analysis of plasma samples taken from patients in clinical settings, among other uses. In this regard, stability of a reagent containing NAD(P)H is improved, enhancing shelf life and results in the detection of ammonia. In an exemplary reagent ammonia released as a result of NAD(P)H decay is scavenged using an enzymatic reaction to convert the ammonia using GLDH, NAD(P)H and 2-oxoglutarate, thereby forming L-glutamate, NAD(P)+ and Η2O in the NAD(P)H containing reagent.
    查看更多

    同类化合物

    烟酸单核苷酸 β-烟酰胺单核苷酸 3-氨基甲酰-1-[5-O-(羟基膦酸)-alpha-D-呋喃核糖基]吡啶鎓 but-3-yn-l-yl (((2R,3S,4R,5R)-5-(3-carbamoylpyridin-l-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl) phosphate nicotinamide mononucleotide nicotinate D-ribonucleotide 1,4-dihydronicotinamide adenine dinucleotide α-Nicotinamid-mononucleotid 3-Carbamoyl-1-((2S,3S,4R,5S)-3,4-dihydroxy-5-phosphonooxymethyl-tetrahydro-furan-2-yl)-pyridinium NMNH Nicotinamide-benzimidazole dinucleotide [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl 2-[2-(2-methoxyphenoxy)ethoxy]ethyl phosphate [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl 2-[1-[5-(naphthalen-1-ylmethylamino)-5-oxopentyl]triazol-4-yl]ethyl phosphate 2-(1-adamantyl)ethyl [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate 2-[1-[5-(benzhydrylamino)-5-oxopentyl]triazol-4-yl]ethyl [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl 2-[2-(3-methylphenoxy)ethoxy]ethyl phosphate [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl 2-phenylethyl phosphate [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl 5-phenoxypentyl phosphate [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl 2-[1-[5-oxo-5-[(4-phenylphenyl)methylamino]pentyl]triazol-4-yl]ethyl phosphate 2-(1-benzyltriazol-4-yl)ethyl [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl 2-[2-(3-fluorophenoxy)ethoxy]ethyl phosphate butyl [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate 1-(3'-deoxy-3'-fluoro-β-D-xylofuranosyl)nicotinamide-5'-phosphate 1-(3'-azido-3'-deoxy-β-D-ribofuranosyl)nicotinamide-5'-(benzyl phosphate) 1-(3'-azido-3'-deoxy-β-D-ribofuranosyl)nicotinamide-5'-(butyl phosphate) [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl methyl phosphate beta-Nicotinamide mononucleotide [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl methyl hydrogen phosphate 1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxylic acid 1-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxylic acid [(2R,3S,4R,5R)-5-(benzimidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono phosphate [[(2R,3R,4R,5R)-5-amino-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate 1-[(2R,3R,4R,5S)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxylic acid [(2S,3S,4R,5S)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate [amino-[5-azanidyl-1-[5-[[[[5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxymethyl]-4-hydroxy-3-phosphonooxyoxolan-2-yl]imidazolidine-4,5-diid-4-yl]methyl]azanide [(2S,3R,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate 1-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxylic acid Pyridinium, 3-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)-, inner salt [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[(2S,3R,4S,5S)-3,4-dihydroxy-5-(4-naphthalen-1-yltriazol-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphate [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[(2S,3R,4S,5S)-3,4-dihydroxy-5-(4-phenyltriazol-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphate [[(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2S,3R,4S,5S)-3,4-dihydroxy-5-(4-phenyltriazol-1-yl)oxolan-2-yl]methyl hydrogen phosphate β-nicotinamide mononucleotide [(2R,3R,4S,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate 1-[(2R,3R,4S,5S)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxylic acid [(2S,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate 1-[(2R,3S,4S,5S)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxylic acid 1-[(2S,3R,4S,5S)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxylic acid [(2S,3S,4S,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate [(2S,3S,4S,5S)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate 1-[(2S,3S,4S,5S)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxylic acid

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