[(2R,3S,4R)-2,3,4-三羟基-6-氧代己基]磷酸二氢酯 | 3573-50-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 中文名称: [(2R,3S,4R)-2,3,4-三羟基-6-氧代己基]磷酸二氢酯
• 英文名称: 2-Deoxy-D-arabino-hexose 6-(dihydrogen phosphate)
• 英文别名: [(2R,3S,4R)-2,3,4-trihydroxy-6-oxohexyl] dihydrogen phosphate
• CAS: 3573-50-0
• 化学式: C₆H₁₃O₈P
• 分子量: 244.14
• InChiKey: MBPFNOMGYSRGQZ-PBXRRBTRSA-N

物化性质

• 沸点：
  606.9±65.0 °C(Predicted)
• 密度：
  1.694±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  145
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Use of antisense oligonucleotide libraries for identifying gene function
  申请人：——

  公开号：US20030054354A1

  公开（公告）日：2003-03-20

  A method for identifying one or more genes involved in a phenotype of cells, tissues or organisms, comprising the steps of contacting cells, tissues or organisms which exhibit the phenotype with a library of antisense oligonucleotides and performing a primary phenotypic assay to determine which antisense oligonucleotides in the library attenuate the phenotype. These antisense oligonucleotides correspond to genes involved in the phenotype. The method may be used to identify genes involved in various disease states.

  一种用于识别与细胞、组织或生物体表型相关的一个或多个基因的方法，包括以下步骤：将显示该表型的细胞、组织或生物体与一个反义寡核苷酸文库接触，并进行主要表型分析以确定文库中哪些反义寡核苷酸减弱了该表型。这些反义寡核苷酸对应于参与表型的基因。该方法可用于识别参与各种疾病状态的基因。
• Dehydroquinate dehydrase/shikimate dehydrogenase as a herbicide target
  申请人：——

  公开号：US20030145348A1

  公开（公告）日：2003-07-31

  The present invention relates to the use of nucleic acid sequences encoding a polypeptide with dehydroquinate dehydratase/shikimate dehydrogenase activity for generating an assay system for finding dehydroquinate dehydratase/shikimate dehydrogenase inhibitors. Using antisense techniques, it was shown for the first time that dehydroquinate dehydratase/shikimate dehydrogenase constitutes a target for herbicides. Moreover, the application relates to the generation of transgenic plants comprising a nucleic acid sequence encoding a polypeptide with dehydroquinate dehydratase/shikimate dehydrogenase (E.C. 4.2.1.10/E.C. 1.1.1.25) activity which comprises an increased biomass production and/or an increased content in aromatic amino acids in comparison with a nontransgenic plant.

  本发明涉及使用编码具有脱氢奎酸脱水酶/香草酸脱氢酶活性的多肽的核酸序列，用于生成寻找脱氢奎酸脱水酶/香草酸脱氢酶抑制剂的测定系统。通过反义技术，首次证明脱氢奎酸脱水酶/香草酸脱氢酶是除草剂的靶标。此外，本申请涉及生成转基因植物，其中包括编码具有脱氢奎酸脱水酶/香草酸脱氢酶（E.C. 4.2.1.10/E.C. 1.1.1.25）活性的核酸序列，其具有相对于非转基因植物增加的生物量产量和/或芳香族氨基酸含量。
• USE OF ANTISENSE OLIGONUCLEOTIDE LIBRARIES FOR IDENTIFYING GENE FUNCTION
  申请人：Bennett C. Frank

  公开号：US20090023599A1

  公开（公告）日：2009-01-22

  A method for identifying one or more genes involved in a phenotype of cells, tissues or organisms, comprising the steps of contacting cells, tissues or organisms which exhibit the phenotype with a library of antisense oligonucleotides and performing a primary phenotypic assay to determine which antisense oligonucleotides in the library attenuate the phenotype. These antisense oligonucleotides correspond to genes involved in the phenotype. The method may be used to identify genes involved in various disease states.

  一种用于鉴定细胞、组织或生物体表现出的一个或多个表型所涉及的基因的方法，包括以下步骤：将表现出该表型的细胞、组织或生物体与反义寡核苷酸文库接触，并进行初级表型测定，以确定文库中哪些反义寡核苷酸减弱了该表型，这些反义寡核苷酸对应于参与该表型的基因。该方法可用于鉴定参与各种疾病状态的基因。
• COMPOUNDS FROM ANTRODIA CAMPHORATE AND THEIR USE IN TREATMENT OF DIABETES MELLITUS
  申请人：National Dong Hwa University

  公开号：US20150203430A1

  公开（公告）日：2015-07-23

  The present invention relates to a method or composition for treating diabetes mellitus, comprising administering a subject with a pharmaceutical composition comprising a therapeutically effective amount of an active compound from Antrodia camphorate , such as antroquinonols, and a pharmaceutically acceptable carrier. In addition, the prevent invention provides a new process for the total synthesis of antroquinonol. Also provided are the new compounds produced during the process for preparing of antroquinonol.

  本发明涉及一种治疗糖尿病的方法或组合物，包括给予受试者一种含有Antrodia camphorate的活性化合物（如antroquinonols）的治疗有效量的制药组合物和药学上可接受的载体。此外，本发明提供了一种新的antroquinonol的全合成过程。同时，还提供了在制备antroquinonol过程中产生的新化合物。
• TRACERS FOR MONITORING THE ACTIVITY OF SODIUM/GLUCOSE COTRANSPORTERS IN HEALTH AND DISEASE
  申请人：Wright Ernest M.

  公开号：US20100008856A1

  公开（公告）日：2010-01-14

  Radiolabeled tracers for sodium/glucose cotransporters (SGLTs), their synthesis, and their use are provided. The tracers are methyl or ethyl pyranosides having an equatorial hydroxyl group at carbon-2 and a C1 preferred conformation, radio-labeled with 18 F, 123 I, or 124 I, or free hexoses radiolabeled with 18 F, 123 I, or 124 I. Also provided are in vivo and in vitro techniques for using these and other tracers as analytical and diagnostic tools to study glucose transport, in health and disease, and to evaluate therapeutic interventions.

  提供了钠/葡萄糖共转运体（SGLT）的放射性标记示踪剂，它们的合成和使用。这些示踪剂是甲基或乙基吡喃糖，具有2碳处的赤道羟基和C1优先构象，放射性标记为18F，123I或124I，或放射性标记为18F，123I或124I的自由己糖。还提供了使用这些和其他示踪剂作为分析和诊断工具研究葡萄糖转运的体内和体外技术，在健康和疾病中，并评估治疗干预措施。