三(3,4-二甲基苯基)磷酸酯 | 3862-11-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 中文名称: 三(3,4-二甲基苯基)磷酸酯
• 英文名称: phosphoric acid tris-(3,4-dimethyl-phenyl ester)
• 英文别名: Phosphorsaeure-tris-(3,4-dimethyl-phenylester)；3,4-dimethyl-phenol, phosphate (3:1)；tris(3,4-dimethylphenyl) phosphate；phosphoric acid 3,4-xylyl ester；Tris-<3,4-dimethyl-phenyl>-phosphat
• CAS: 3862-11-1
• 化学式: C₂₄H₂₇O₄P
• 分子量: 410.45
• InChiKey: BCTKCHOESSAGCN-UHFFFAOYSA-N

物化性质

• 熔点：
  72°C
• 沸点：
  243.75°C (estimate)
• 密度：
  1.170 (estimate)
• 颜色/状态：
  Wax
• 溶解度：
  Sol in benzene; slightly soluble in ethanol and hexane

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

ADMET

毒理性

• 解毒与急救

基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，如有需要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，如有必要进行治疗……。监测休克，如有必要进行治疗……。预见并处理癫痫发作……。对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用生理盐水连续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的干呕反射且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……。在去污后，用干燥的无菌敷料覆盖皮肤烧伤……。/毒药A和B/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

高级治疗：对于无意识、严重肺水肿或呼吸停止的患者，考虑进行口咽或鼻咽气管插管以控制气道。使用气囊面罩装置的正压通气技术可能有益。监测心率和必要时治疗心律失常。 ... 开始静脉输液，使用D5W/SRP：“保持开放”，最低流量/。如果出现低血容量的迹象，使用乳酸钠林格氏液。注意液体过载的迹象。考虑使用药物治疗肺水肿。对于伴有低血容量迹象的低血压，谨慎给予液体。注意液体过载的迹象。用地西泮（安定）治疗癫痫。使用丙美卡因氢氯化物协助眼部冲洗。/毒药A和B/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

没有在口服三(3,4-二甲苯基)磷酸的公鸡中发现神经麻痹效应。当以1克/千克/天的剂量口服给药40天时，三(3,4-二甲苯基)磷酸显示出低毒性。

NO NEUROPARALYTIC EFFECTS WERE FOUND IN ROOSTERS GIVEN TRI(3,4-XYLENYL) PHOSPHATE ORALLY. WHEN ADMIN AT 1 G/KG/DAY FOR 40 DAYS ORALLY TRI(3,4-XYLENYL) PHOSPHATE SHOWED LOW TOXICITY.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

96小时半致死浓度(LC50)和半效应浓度(EC50)测试是使用31天大的大头鲦进行的。温度为23.7°C；溶解氧为6.4毫克/升；水的硬度为45.0毫克/升，以CaCO3计；碱度为44.5毫克/升，以CaCO3计；pH值为7.80；容器体积为0.25升。测试是使用单细胞毒性筛选系统和测试化学物质80%饱和溶液（3.8微克/升）的90%纯度进行的。在测试期间没有发生死亡，也没有鱼受到压力。

96 hr LC50 & EC50 tests were conducted using fathead minnows at 31 days old. Temp was 23.7 °C; dissolved oxygen was 6.4 mg/l; water hardness was 45.0 mg/l as CaCO3; Alkalinity was 44.5 mg/l as CaCO3; pH was 7.80; tank volume 0.25 l. The test was run using the single cell toxicity screening system & an 80% saturated solution (3.8 ug/l) of the test chemical at 90% purity. No mortality occurred nor were the fish stressed during the test.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 海关编码：
  2919900090

反应信息

• 作为反应物：
  描述：

  三(3,4-二甲基苯基)磷酸酯 、 氰化钾 生成 3,4-二甲基苯腈
  参考文献：
  名称：

  Kreysler, Chemische Berichte, 1885, vol. 18, p. 1716

  摘要：

  DOI：
• 作为产物：
  描述：

  3,4-二甲基苯酚 在 三氯氧磷 作用下， 生成 三(3,4-二甲基苯基)磷酸酯
  参考文献：
  名称：

  Kreysler, Chemische Berichte, 1885, vol. 18, p. 1716

  摘要：

  DOI：

文献信息

• MAKARENKO I. M.; AKSENOVA T. F., SVERDL. IN-T HAP. X-BA. SVERDLOVSK, 1975. 6 S., BIBLIOGR. 12 NAZV. (RUKOP+
  作者：MAKARENKO I. M.、 AKSENOVA T. F.

  DOI：——

  日期：——
• POLYCARBONATE WITH REDUCED COLOR
  申请人：Sabic Innovative Plastics IP B.V.

  公开号：EP2035500A2

  公开（公告）日：2009-03-18
• METHOD FOR MAKING MOLDED POLYCARBONATE ARTICLES WITH IMPROVED COLOR
  申请人：SABIC Innovative Plastics IP B.V.

  公开号：EP2041202B1

  公开（公告）日：2013-05-08
• Method for Making Molded Polycarbonate Articles with Improved Color
  申请人：Berndsen Sjef

  公开号：US20080004407A1

  公开（公告）日：2008-01-03

  A method for preparing a molded article includes the steps of (a) obtaining a polycarbonate resin and (b) molding the polycarbonate resin. The polycarbonate resin is made by a transesterification reaction using an activated diaryl carbonate such that the polycarbonate is susceptible to the formation of internal ester linkages (IEL). The method occurs with the proviso that the polycarbonate resin, the molding conditions or both are selected to control the amount of IEL formed during the molding process to a level of less than 0.4 mol %.
• Polycarbonate with Reduced Color
  申请人：Berndsen Sjef

  公开号：US20080004379A1

  公开（公告）日：2008-01-03

  A method of making polycarbonate includes the steps of forming polycarbonate by a melt transesterification method using an activated diaryl carbonate, and compounding the polycarbonate with a phosphorus-containing compound that has an abstractable proton or hydrolyzable group. The phosphorus-containing compound is compounded with the polycarbonate in an amount sufficient to result in an improvement in the color properties of the polycarbonate as compared to pellets formed from the same polycarbonate without addition of the phosphorus-containing compound.