Hydroxy-(3-methoxy-4-phosphonooxy-phenyl)-acetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: Hydroxy-(3-methoxy-4-phosphonooxy-phenyl)-acetic acid
• 英文别名: 2-Hydroxy-2-(3-methoxy-4-phosphonooxyphenyl)acetic acid；2-hydroxy-2-(3-methoxy-4-phosphonooxyphenyl)acetic acid
• 化学式: C₉H₁₁O₈P
• 分子量: 278.155
• InChiKey: ANVJXOAPXKDSCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  134
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Hydroxy-(3-methoxy-4-phosphonooxy-phenyl)-acetic acid 在 anti-H₃ mAb phosphate buffer 作用下， 反应 2.0h， 生成 3-甲氧基-4-羟基扁桃酸
  参考文献：
  名称：

  Competitive immunoassay (Cat-EIA), a helpful technique for catalytic antibody detection. Part II

  摘要：

  The Cat-EIA procedure, described in part I, was successfully applied to the screening of 5 different catalytic activities on a given set of 11 mAbs. The precautions required to devoid false-positive identification (preceding paper), were taken into account. Two catalylic activities were thus detected, including a newly thioacetal hydrolysis. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00068-4

文献信息

• Competitive immunoassay (Cat-EIA), a helpful technique for catalytic antibody detection. Part II
  作者：F. Taran、P.Y. Renard、C. Créminon、A. Valleix、Y. Frobert、P. Pradelles、J. Grassi、C. Mioskowski

  DOI：10.1016/s0040-4039(99)00068-4

  日期：1999.3

  The Cat-EIA procedure, described in part I, was successfully applied to the screening of 5 different catalytic activities on a given set of 11 mAbs. The precautions required to devoid false-positive identification (preceding paper), were taken into account. Two catalylic activities were thus detected, including a newly thioacetal hydrolysis. (C) 1999 Elsevier Science Ltd. All rights reserved.