trans-2-oxo-2-tetrahydrofurfuryloxy-4-chloromethyl-1,3,2-dioxaphosphorinane

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: trans-2-oxo-2-tetrahydrofurfuryloxy-4-chloromethyl-1,3,2-dioxaphosphorinane
• 英文别名: (2R,4S)-4-(chloromethyl)-2-(oxolan-2-ylmethoxy)-1,3,2lambda5-dioxaphosphinane 2-oxide；(2R,4S)-4-(chloromethyl)-2-(oxolan-2-ylmethoxy)-1,3,2λ5-dioxaphosphinane 2-oxide
• 化学式: C₉H₁₆ClO₅P
• 分子量: 270.65
• InChiKey: XYFRMTRCXSIJBZ-GTUHMOCJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  四氢糠醇 、 2-oxo-2-chloro-4-chloromethyl-1,3,2-dioxaphosphorinane 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以38%的产率得到cis-2-oxo-2-tetrahydrofurfuryloxy-4-chloromethyl-1,3,2-dioxaphosphorinane
  参考文献：
  名称：

  摘要：

  A series of 2-N and 2-O-substituted 2-oxo-4-chloromethyl-1,3,2-dioxaphosphorinaiies were prepared by reaction of amines and alcohols with 2-oxo-2-chloro-4-chloromethyl- 1,3,2-dioxaphosphorinane. The structure of compounds obtained was proved by means of H-1 and C-13 NMR spectroscopy. Some cyclic amidocyclophosphates possessed biological activity as inhibitors of mitotic fission and of Na+/H+ exchange.

  DOI：

  10.1023/a:1026080422837

文献信息

• ——
  作者：A. M. Koroteev、G. B. Krasnov、M. P. Koroteev、E. E. Nifantyev

  DOI：10.1023/a:1026080422837

  日期：——

  A series of 2-N and 2-O-substituted 2-oxo-4-chloromethyl-1,3,2-dioxaphosphorinaiies were prepared by reaction of amines and alcohols with 2-oxo-2-chloro-4-chloromethyl- 1,3,2-dioxaphosphorinane. The structure of compounds obtained was proved by means of H-1 and C-13 NMR spectroscopy. Some cyclic amidocyclophosphates possessed biological activity as inhibitors of mitotic fission and of Na+/H+ exchange.