六氟砷酸钠 - CAS号 12005-86-6

物化性质

稳定性/保质期：

遵照规格使用和储存则不会分解。

计算性质

辛醇/水分配系数(LogP)：

-0.86
重原子数：

8
可旋转键数：

0
环数：

0.0
sp3杂化的碳原子比例：

0.0
拓扑面积：

0
氢给体数：

0
氢受体数：

7

安全信息

危险等级：

6.1
危险品标志：

T,N
安全说明：

S20/21,S28,S45,S60,S61
危险类别码：

R23/25
WGK Germany：

3
海关编码：

28269080
危险品运输编号：

1557
RTECS号：

WB2775000
包装等级：

II
危险类别：

6.1
危险标志：

GHS06,GHS09
危险性描述：

H301 + H331,H410
危险性防范说明：

P261,P273,P301 + P310,P311,P501
储存条件：

请将密封产品存放在阴凉干燥的地方。

SDS

SDS：8f2763abad2c089e57e3bb82fd17d5b3

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Name:	Sodium Hexafluoroarsenate(v) 99% Material Safety Data Sheet
Synonym:	None reported
CAS:	12005-86-6

Section 1 - Chemical Product MSDS Name:Sodium Hexafluoroarsenate(v) 99% Material Safety Data Sheet
Synonym:None reported

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
12005-86-6	Sodium hexafluoroarsenate (V)	99	unlisted

Hazard Symbols: XN
Risk Phrases: 36/37/38 40

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin. Limited evidence of a carcinogenic effect.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inorganic fluorides can be harmful. Acute exposure to fluorine compounds can lead to digestive tract burns, and abdominal pain.
Inhalation:
May cause respiratory tract irritation. May cause effects similar to those described for ingestion. The toxicological properties of this substance have not been fully investigated.
Chronic:
Chronic inhalation and ingestion may cause chronic fluoride poisoning (fluorosis) characterized by weight loss, weakness, anemia, brittle bones, and stiff joints. May cause cancer in humans.
Chronic effects include excessive calcification of the bones, ligaments, and tendons. Chronic exposure to fluoride compounds may cause systemic toxicity.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.
Storage:
Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 12005-86-6: United Kingdom, WEL - TWA: (listed as arsenic compounds, n.o.s.): mg/m3 TWA (except arsine, as As) United Kingdom, WEL - STEL: (listed as arsenic compounds, n.o.s.) 0.3 mg/m3 STEL (except arsine, as As) Japan: (listed as arsenic compounds, n.o.s.): 3 g/m3 OEL (refere value, as As) Spain: (listed as arsenic compounds, n.o.s.): 0.1 mg/m3 VLA-ED (a As) Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Crystals
Color: colorless
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: soluble
Specific Gravity/Density:
Molecular Formula: AsF6Na
Molecular Weight: 211.91

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Hydrogen fluoride gas, oxides of arsenic, sodium oxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 12005-86-6: WB2775000 LD50/LC50:
CAS# 12005-86-6: Oral, rat: LD50 = 880 mg/kg.
Carcinogenicity:
Sodium hexafluoroarsenate (V) - IARC: Group 1 carcinogen (listed as Arsenic compounds, n.o.s.).
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: ARSENIC COMPOUND, SOLID, N.O.S.
Hazard Class: 6.1
UN Number: 1557
Packing Group: II
IMO
Shipping Name: ARSENIC COMPOUND, SOLID, N.O.S.
Hazard Class: 6.1
UN Number: 1557
Packing Group: II
RID/ADR
Shipping Name: ARSENIC COMPOUND, SOLID, N.O.S.
Hazard Class: 6.1
UN Number: 1557
Packing group: II

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
R 40 Limited evidence of a carcinogenic effect.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37 Wear suitable protective clothing and
gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 12005-86-6: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 12005-86-6 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 12005-86-6 is not listed on the TSCA inventory.
It is for research and development use only.

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

作为反应物：

描述：

六氟砷酸钠、 mer-Ru(CO)2(PhP(CH2CH2CH2PCy2)2) 在 Br₂ 作用下，以苯为溶剂，以65%的产率得到cis-{RuBr(CO)2(bis(3-(dicyclohexylphosphino)propyl)phenylphosphine)}AsF6

参考文献：

名称：

两种柔性螯合三膦配体的钌（0）和钌（II）配合物的合成与表征

摘要：

DOI：

10.1021/om00078a001
作为产物：

描述：

sodium fluoride 、 arsenic pentafluoride 以氢氟酸为溶剂，生成六氟砷酸钠

参考文献：

名称：

氟化氢溶剂系统-氟酸的盐。溶剂分解

摘要：

已经通过蒸发含有过量挥发性酸性成分的盐的无水HF溶液来确定许多氟代酸的固体盐的化学计量。已检查了P，As，Ge，Se，Te和I的氟酸盐。其中许多是高度溶剂化的。据报道新的氟化氢BaHF 3。

DOI：

10.1016/0022-1902(57)80082-7
作为试剂：

描述：

(4-chlorophenyl)(mesityl)iodonium trifluoromethanesulfonate 在六氟砷酸钠作用下，以水、乙腈为溶剂，反应 1.0h，生成 (4-chlorophenyl)(mesityl)iodonium hexafluoroarsenate

参考文献：

名称：

铜催化手性环戊烯与二芳基碘鎓盐的对映体选择性芳香化脱对称

摘要：

开发了铜催化的手性环戊烯与二芳基碘鎓盐的对映体选择性芳基脱对称。在原位生成催化量的手性铜-双恶唑啉络合物的情况下，4-取代或4,4-二取代的环戊-1-烯与六氟砷化二芳基碘鎓的反应提供了高收率的手性芳基化产物优异的对映选择性。含环己基的Box配体对于高对映选择性至关重要。还记录了对映体富集的加合物向其他手性结构单元的转化。

DOI：

10.1002/anie.201713329

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文献信息

One-Step and Two-Step Spin-Crossover Iron(II) Complexes of ((2-Methylimidazol-4-yl)methylidene)histamine

作者：Tetsuya Sato、Koshiro Nishi、Seiichiro Iijima、Masaaki Kojima、Naohide Matsumoto

DOI：10.1021/ic9006197

日期：2009.8.3

A tridentate ligand ((2-methylimidazol-4-yl)methylidene)histamine (abbreviated as H2L2-Me), that is, the 1:1 condensation product of 2-methyl-4-formylimidazole and histamine, was used for the syntheses of a new family of iron(II) spin-crossover (SCO) complexes with the general chemical formulas [Fe(H2L2-Me)2]X2·solvent (X = Cl, ClO4, and BPh4; solvent = 2-PrOH and CH3CN) and [Fe(H2L2-Me)2]X·Y·solvent

使用三齿配体（（2-甲基咪唑-4-基）亚甲基）组胺（缩写为H 2 L 2-Me），即2-甲基-4-甲酰咪唑与组胺的1：1缩合产物。化学通式为[Fe（H 2 L 2-Me）2 ] X 2 ·溶剂（X = Cl，ClO 4和BPh 4的新的铁（II）自旋交联（SCO）配合物家族的合成;溶剂= 2-PrOH和CH 3 CN）和[Fe（H 2 L 2-Me）2 ] X·Y·溶剂（X = Cl和Br; Y = ClO 4，BF 4，PF 6和AsF6；溶剂= EtOH和2-PrOH）。复杂阳离子[Fe（H 2 L 2-Me）2 ] 2+是由于两个不对称三齿配体的八面体配位而形成的手性物种，在自旋交叉点附近具有配体场强，并与氢键合阴离子形成各种网络结构。二氯化物络合物[Fe（H 2 L 2-Me）2 ] Cl 2 ·2-PrOH·0.5H 2 O（1）和[Fe（H 2 L 2-Me）2 ] Cl 2 ·2-PrOH·H
PROCESS AND INTERMEDIATES FOR PREPARING A JAK1 INHIBITOR

申请人：Incyte Corporation

公开号：US20220056034A1

公开（公告）日：2022-02-24

The present invention is related to processes for preparing itacitinib, or a salt thereof, and related synthetic intermediates related thereto.

本发明涉及制备伊他西替尼或其盐的工艺，以及与之相关的合成中间体。
PROCESS AND INTERMEDIATES FOR PREPARING A JAK INHIBITOR

申请人：Incyte Corporation

公开号：US20220056035A1

公开（公告）日：2022-02-24

The present invention is related to processes for preparing ruxolitinib, or a salt thereof, and related synthetic intermediates related thereto.

本发明涉及制备瑞托利尼布或其盐的方法，以及相关的合成中间体。
Utilization of a Nonemissive Triphosphine Ligand to Construct a Luminescent Gold(I)-Box That Undergoes Mechanochromic Collapse into a Helical Complex

作者：Daniel T. Walters、Reza Babadi Aghakhanpour、Xian B. Powers、Kamran B. Ghiassi、Marilyn M. Olmstead、Alan L. Balch

DOI：10.1021/jacs.8b01666

日期：2018.6.20

grinding of blue luminescent crystals containing the cation, [Au6(Triphos)4Cl]5+, results in their conversion into amorphous solids with green emission that contain the bridged helicate cation, [μ-ClAu3(Triphos)2}2]5+. A mechanism of the mechanochromic transformation is proposed. The structures of the blue-emitting helicate, [Au3(Triphos)2](CF3SO3)3·4(CH3C6H5)·H2O, and the green-emitting bridged-helicate

发光金(I)配合物([Au6(Triphos)4Cl](PF6)5·2(CH3C6H5)、[Au6(Triphos)4Cl](AsF6)5·8(CH3C6H5)和[Au6(Triphos)4Cl]( SbF6)5·7(CH3C6H5)，其中Triphos = 双(2-二苯基膦乙基)苯基膦) 具有盒状结构已经制备和结晶学表征。氯离子位于盒子的中心，附近有六个金（I）离子中的两个。对含有阳离子 [Au6(Triphos)4Cl]5+ 的蓝色发光晶体进行机械研磨，将其转化为具有绿色发射的无定形固体，其中含有桥接螺旋阳离子 [μ-ClAu3(Triphos)2}2] 5+。提出了机械变色转变的机制。发蓝光的螺旋结构 [Au3(Triphos)2](CF3SO3)3·4(CH3C6H5)·H2O 和发绿光的桥接螺旋结构，
Stepwise Spin Transition and Hysteresis of a Tetrameric Iron(II) Complex, <i>fac</i> ‐[Tris(2‐methylimidazol‐4‐ylmethylidene‐ <i>n</i> ‐hexylamine)]iron(II) Chloride Hexafluorophosphate, Assembled by Imidazole···Chloride Hydrogen Bonds

作者：Koshiro Nishi、Hiroki Kondo、Takeshi Fujinami、Naohide Matsumoto、Seiichiro Iijima、Malcolm A. Halcrow、Yukinari Sunatsuki、Masaaki Kojima

DOI：10.1002/ejic.201201298

日期：2013.2.18

A spin-crossover iron(II) complex, fac-[FeII(HLn-Hx)3]Cl·PF6 (1), that exhibits stepwise spin transition and thermal hysteresis was synthesized by using the ligand 2-methylimidazol-4-ylmethylidene-n-hexylamine (HLn-Hx). Four complex cations (fac-[FeII(HLn-Hx)3]2+) and four Cl– anions associate through twelve imidazole···Cl– H bonds to give a tetrameric cubane-like assembly, and one PF6– anion is encapsulated

通过使用配体 2-甲基咪唑-4-基亚甲基-合成了具有逐步自旋跃迁和热滞后的自旋交叉铁 (II) 配合物 fac-[FeII(HLn-Hx)3]Cl·PF6 (1)-正己胺 (HLn-Hx)。四个复合阳离子 (fac-[FeII(HLn-Hx)3]2+) 和四个 Cl- 阴离子通过十二个咪唑…Cl-H 键结合形成四聚立方体状组装体，一个 PF6- 阴离子被包裹在立方体的空腔内。磁化率测量显示三步自旋转变，随着扫描速率的增加，自旋交叉分布变得不那么明显。在 0.5 K min-1 的扫描速率下，三个步骤的中点温度在加热模式下为 Tc() = 131.2、144.2 和 154.2 K，在冷却模式下为 Tc() = 116.8、137.8 和 151.8 K . 各自的热滞后被评估为 14.4、6.3、

六氟砷酸钠 | 12005-86-6

物质功能分类

分子结构分类

物化性质

计算性质

安全信息

SDS

反应信息

文献信息

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