3-Benzyl-6-butylfuro[2,3-d]pyrimidin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃[2,3-d]嘧啶
• 英文名称: 3-Benzyl-6-butylfuro[2,3-d]pyrimidin-2-one
• 化学式: C₁₇H₁₈N₂O₂
• 分子量: 282.34
• InChiKey: KWGWBNPZFDYNMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  41.9
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Pyrimidine compounds as anti-ictogenic and/or anti-epileptogenic agents
  申请人：Queen's University

  公开号：US20030153584A1

  公开（公告）日：2003-08-14

  Methods and compounds useful for the inhibition of convulsive disorders, including epilepsy, are disclosed. The methods and compounds of the invention inhibit or prevent ictogenesis and/or epileptogenesis. Methods for preparing the compounds of the invention are also described. Particularly preferred compounds of the invention include: 1

  本发明揭示了用于抑制惊厥性疾病，包括癫痫的方法和化合物。本发明的方法和化合物能够抑制或预防发作和/或癫痫发生。本发明还描述了制备本发明化合物的方法。本发明特别优选的化合物包括：1
• EP1385831A2
  申请人：——

  公开号：EP1385831A2

  公开（公告）日：2004-02-04
• US7501429B2
  申请人：——

  公开号：US7501429B2

  公开（公告）日：2009-03-10
• [EN] PYRIMIDINE COMPOUNDS AS ANTI-ICTOGENIC AND/OR ANTI-EPILEPTOGENIC AGENTS<br/>[FR] COMPOSES DE PYRIMIDINE EN TANT QU'AGENTS ANTI-ICTOGENIQUES ET/OU ANTI-EPILEPTIQUES
  申请人：UNIV KINGSTON

  公开号：WO2002083651A2

  公开（公告）日：2002-10-24

  Methods and compounds useful for the inhibition of convulsive disorders, including epilepsy, are disclosed. The methods and compounds of the invention inhibit or prevent ictogenesis and/or epileptogenesis. Methods for preparing the compounds of the invention are also described. Compounds of the invention include formula (XIV), where R9-R12 are as in claim 1.