silybin

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 黄酮木脂素
• 英文名称: silybin
• 英文别名: silibinin；silymarin；(3R)-3,5,7-trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one
• 化学式: C₂₅H₂₂O₁₀
• 分子量: 482.444
• InChiKey: SEBFKMXJBCUCAI-DBEOCMILSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  35
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  155
• 氢给体数：
  5
• 氢受体数：
  10

文献信息

• Nanostructured formulations for the delivery of silibinin and other active ingredients for treating ocular diseases
  申请人：DISTRETTO TECNOLOGICO SICILIA MICRO E NANO SISTEMI S.C.A.R.L.

  公开号：US11253526B2

  公开（公告）日：2022-02-22

  Formulations are described, containing silibinin or other active ingredients incorporated in lipid nanoparticle systems of the SLN and NLC type, and based on calixarenes, possibly mucoadhesive, or in micellar and nanoparticle systems based on amphiphilic inulin copolymers for use in the treatment of neurodegenerative ocular diseases. The versatility of the calixarene compound is also described, capable of charging and releasing active ingredients characterized by low water solubility, easy chemical and enzymatic degradation, low bioavailability, either of natural origin or not, to be used in the treatment of ocular diseases.

  描述的制剂含有掺入 SLN 和 NLC 型脂质纳米粒子系统中的 Silibinin 或其他活性成分，这些制剂基于卡利卡尼（可能具有粘液粘附性），或基于两亲性菊粉共聚物的胶束和纳米粒子系统，用于治疗神经退行性眼部疾病。此外，还介绍了钙烯类化合物的多功能性，它能够装载和释放具有低水溶性、易化学和酶降解、生物利用率低等特点的活性成分，可用于治疗眼部疾病。
• PROCESS FOR TOTAL SYNTHESIS OF FLAVONOID COMPOUNDS AND ISOMERS THEREOF
  申请人：COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

  公开号：US20160362401A1

  公开（公告）日：2016-12-15

  The present invention relates to the a process for total synthesis of flavonoid compounds of general formula I and isomers thereof wherein R 1 and R 2 is OH; R 3 ═H or The present invention particularly relates to the process for preparation and separation of (2S,3S)-taxifolin-6-C-β-D-glucopyranoside (ulmoside A), (2R,3R)-taxifolin-6-C-β-D-glucopyranoside and taxifolin.
• NANOSTRUCTURED FORMULATIONS FOR THE DELIVERY OF SILIBININ AND OTHER ACTIVE INGREDIENTS FOR TREATING OCULAR DISEASES
  申请人：DISTRETTO TECNOLOGICO SICILIA MICRO E NANO SISTEMI S.C.A.R.L.

  公开号：US20210046083A1

  公开（公告）日：2021-02-18

  Formulations are described, containing silibinin or other active ingredients incorporated in lipid nanoparticle systems of the SLN and NLC type, and based on calixarenes, possibly mucoadhesive, or in micellar and nanoparticle systems based on amphiphilic inulin copolymers for use in the treatment of neurodegenerative ocular diseases. The versatility of the calixarene compound is also described, capable of charging and releasing active ingredients characterized by low water solubility, easy chemical and enzymatic degradation, low bioavailability, either of natural origin or not, to be used in the treatment of ocular diseases.
• US9611255B2
  申请人：——

  公开号：US9611255B2

  公开（公告）日：2017-04-04