[(2R,3S,5R)-5-(6-aminopurin-9-yl)-2-methyloxolan-3-yl] [hydroxy-[hydroxy(phosphonooxy)phosphoryl]oxyphosphoryl] hydrogen phosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核糖核苷3'-磷酸盐
• 英文名称: [(2R,3S,5R)-5-(6-aminopurin-9-yl)-2-methyloxolan-3-yl] [hydroxy-[hydroxy(phosphonooxy)phosphoryl]oxyphosphoryl] hydrogen phosphate
• 化学式: C₁₀H₁₇N₅O₁₄P₄
• 分子量: 555.16
• InChiKey: JOGIUAASWHTLQG-DSYKOEDSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.3
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  285
• 氢给体数：
  6
• 氢受体数：
  18

文献信息

• Methods for cyclic nucleotide determination
  申请人：Promega Corporation

  公开号：EP2400029A2

  公开（公告）日：2011-12-28

  The present invention relates in general to cellular analysis tools and more particularly to methods of determining cyclic nucleotide concentrations in samples.

  本发明总体上涉及细胞分析工具，更具体地说，涉及确定样品中环核苷酸浓度的方法。
• Assay for phosphodiesterases
  申请人：Promega Corporation

  公开号：EP2392667A2

  公开（公告）日：2011-12-07

  The present invention relates in general to cellular analysis tools and more particularly to methods of determining cyclic nucleotide concentrations in samples.

  本发明总体上涉及细胞分析工具，更具体地说，涉及确定样品中环核苷酸浓度的方法。
• Systems and methods for determining cyclic nucleotide concentration and related pathway activation
  申请人：PROMEGA CORPORATION

  公开号：US10781472B2

  公开（公告）日：2020-09-22

  The present invention relates in general to cellular analysis tools and more particularly to methods and systems for detecting or determining cyclic nucleotide concentrations and related pathway activation in samples. Samples containing cyclic nucleotides may be contacted with a cyclic nucleotide-dependent protein kinase (e.g., cAMP- and cGMP-dependent protein kinases) and a detection system that includes a substrate capable of being phosphorylated by the cyclic nucleotide-dependent protein kinase. The activity of cyclic nucleotide related cell signaling pathways may be measured based on detecting the activity of the cyclic nucleotide-dependent protein kinase.

  本发明总体上涉及细胞分析工具，更具体地说，涉及检测或确定样品中环核苷酸浓度及相关途径活化的方法和系统。含有环核苷酸的样品可与环核苷酸依赖性蛋白激酶（如 cAMP 和 cGMP 依赖性蛋白激酶）和检测系统接触，检测系统包括能被环核苷酸依赖性蛋白激酶磷酸化的底物。环核苷酸相关细胞信号通路的活性可根据检测环核苷酸依赖性蛋白激酶的活性来测量。
• METHODS FOR CYCLIC NUCLEOTIDE DETERMINATION
  申请人：Promega Corporation

  公开号：EP1963366B1

  公开（公告）日：2011-09-14
• EP1963366A4
  申请人：——

  公开号：EP1963366A4

  公开（公告）日：2009-05-06