3,5,6-trichloropyridin-2-yl dihydrogen phosphate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: 3,5,6-trichloropyridin-2-yl dihydrogen phosphate
• 英文别名: (3,5,6-Trichloropyridin-2-yl) dihydrogen phosphate
• 化学式: C₅H₃Cl₃NO₄P
• 分子量: 278.416
• InChiKey: FYFHNBCIPQUYNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  79.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  福司吡酯 在 lead(II) nitrate 作用下， 以 甲醇 、 水 为溶剂， 生成 Phosphoric acid methyl ester 3,5,6-trichloro-pyridin-2-yl ester 、 3,5,6-trichloropyridin-2-yl dihydrogen phosphate
  参考文献：
  名称：

  Divalent Metal Ion-Catalyzed Hydrolysis of Phosphorothionate Ester Pesticides and Their Corresponding Oxonates

  摘要：

  The divalent metal ion-catalyzed hydrolysis of thionate (P=S) and oxonate (P=O) organophosphorus pesticides has been examined in light of three possible catalysis mechanisms: (1) metal ion coordination of the thionate sulfur or oxonate oxygen to enhance the electrophilicity of the phosphorus electrophilic site; (2) metal ion coordination and induced deprotonation of water to create a reactive nucleophile; and (3) metal ion coordination of the leaving group to facilitate its exit. The effect of the following metals at a concentration of 1 mM was examined: COII, Ni-II, Cu-II, Zn-II and Pb-II. These metal ions were chosen for their ability to complex organic ligands and inorganic nucleophiles. Of these metal ions, Cu-II possesses properties most suitable for all three catalytic mechanisms and serves as the most effective catalyst for the five thionate esters (chlorpyrifos-methyl, zinophos, diazinon, parathion-methyi, and ronnel) and the two oxonate esters (chlorpyrifos-methyl oxon and paraoxon) included in this study. A decrease in the degree of Cu-II catalysis at high pH arises from solubility limitations. Pb-II nearly matches Cu-II as a catalyst for oxonate esters, but is a less effective catalyst for thionate esters. Catalysis by Co-II, Ni-II, and Zn-II is negligible. Phenolate product analysis indicates that metal catalysis in some instances shifts hydrolysis from alkyl carbon-centered pathways to phosphorus-centered pathways.

  DOI：

  10.1021/es960499q

文献信息

• CoFe2O4@TiO2 decorated reduced graphene oxide nanocomposite for photocatalytic degradation of chlorpyrifos
  作者：Vinod Kumar Gupta、Tanju Eren、Necip Atar、Mehmet Lütfi Yola、Cemal Parlak、Hassan Karimi-Maleh

  DOI：10.1016/j.molliq.2015.04.032

  日期：2015.8

  Chlorpyrifos is widely used to control pest insects in residential, agricultural, and commercial applications. Its common use has led to the release of chlorpyrifos into sediments, wastewater and water sources. The presence of chlorpyrifos in wastewaters and water sources may affect ecosystem and human health due to its chronicle toxicity to aquatic organisms. In this study, magnetic recoverable CoFe2O4@TiO2 decorated reduced graphene oxide nanocomposite was prepared and used for investigating the photodegradation of chlorpyrifos. The nanocomposite was characterized by using transmission electron microscopy, X-ray photoelectron spectroscopy, X-ray diffraction and scanning electron microscopy. In photocatalytic degradation of chlorpyrifos experiments, the effect of operating variables such as initial chlorpyrifos concentration, catalyst dosage and contact time was also investigated. The photocatalytic degradation of chlorpyrifos followed the pseudo-first-order kinetic model. The results indicated that the nanocomposite exhibited a high efficient photocatalytic activity on the photodegradation of chlorpyrifos. The nanocomposite was separated from the solution by a magnet and reused after the photodegradation of chlorpyrifos. The recyclable of the nanocomposite is economically significant in the industry. (C) 2015 Elsevier B.V. All rights reserved.
• CHARACTERIZATION AND ANALYSIS OF THE COMPOSITION AND DYNAMICS OF THE MAMMALIAN RIBOPROTEOME
  申请人：Beth Israel Deaconess Medical Center, Inc.

  公开号：US20150079590A1

  公开（公告）日：2015-03-19

  The present invention relates to methods for identifying compounds that modulate the translation machinery and methods of diagnosing cancer related to deregulation of the translation machinery. In particular, the methods and diagnostic tests include determining an association between one or more targets and one or more components of the riboproteome and treating a subject with cancer by administering a compound that modulates the association between one or more targets and one or more components of the riboproteome.
• METHODS OF TREATING PROLIFERATIVE DISORDERS WITH MALATE OR DERIVATIVES THEREOF
  申请人：Sukhatme Vikas P.

  公开号：US20150056215A1

  公开（公告）日：2015-02-26

  The present invention relates to methods, compositions, and diagnostic tests for treating and diagnosing proliferative disorders, such as cancel-, that result in dysregulation of malic enzyme 2. In particular, the methods and compositions include monotherapy with malate, or a derivative thereof, as well as combination therapy, such as malate, or a derivative thereof, combined with another therapeutic agent, such as a malic enzyme 2 inhibitor, an antineoplastic agent, a glycolysis inhibitor, an antiangiogenic agent, an immunomodulatory agent, an antibody, or a cytokine.
• METHOD FOR PREDICTING A SUBJECTS RESPONSE TO SLC MODULATOR THERAPY
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US20210254158A1

  公开（公告）日：2021-08-19

  The present invention provides, inter alia, methods for treating or ameliorating the effects of a disorder, such as schizophrenia or bipolar disorder, by increasing or decreasing proline levels. Further provided are methods of predicting and monitoring the clinical response in a patient, and diagnostic systems for identifying a patient likely to benefit from proline modulation.
• US9931313B2
  申请人：——

  公开号：US9931313B2

  公开（公告）日：2018-04-03