aluminum selenide

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 各种混合金属/非金属
• 英文名称: aluminum selenide
• 化学式: Al₂Se₃
• 分子量: 290.843
• InChiKey: NEJFKUNYKSTENI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  5
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  水 、 aluminum selenide 以 水 为溶剂， 生成 selenium
  参考文献：
  名称：

  Formation of μ4-Se2 complex by the oxidative coupling of μ-SeH complex: double-site atomic inversion of the μ4-Se2 complex [{(Cp*Rh)2(μ-CH2)2}2(μ4-Se2)]2+ (Cp*=η5-C5Me5)

  摘要：

  A reaction of trans-[(Cp*Rh)(2)(mu-CH2)(2)Cl-2] with H2Se in MeOH formed a mu-SeH complex isolated as a BPh4 salt [(Cp*Rh)(2)(mu-CH2)(2)(mu-SeH)](BPh4) (1; Cp* = eta(5)-C5Me5). In solution, complex 1 was oxidized by molecular oxygen giving a tetranuclear diselenide mu(4)-Se-2 complex [{(Cp*Rh)(2)(mu-CH2)(2)}(2)(mu(4)-Se-2)](BPh4), (2). The structure involves Se-2 bridging two Rh-Rh bonds (Rh-Rh = 2.6353(5) Angstrom) in a side-on fashion (Rh(1)-Se(1) = 2.4715(6), Rh(2)-Se(1)* = 2.5526(6) Angstrom). The Se(1)Se(1)* distance is 2.3875(9) Angstrom, which corresponds to a Se-Se single bond. Complex 2 showed an intriguing dynamic behavior of double-site atomic inversion at the selenium atoms in CD3CN. The line shape analyses of the temperature dependent H-1-NMR spectra of the mu-CH2 groups elucidated the dynamic process and provided the activation parameters: Delta H-double dagger = 70 +/- 1 kJ mol(-1), Delta S-double dagger = 15 +/- 5 J mol(-1) K-1, and Delta G(double dagger) = 66 +/- 1 kJ mol(-1) (at 298 K). (C) 2000 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0022-328x(00)00474-5

文献信息

• 6-pyridyl substituted pyrimidine derivatives
  申请人：Brown University Research Foundation

  公开号：US05278167A1

  公开（公告）日：1994-01-11

  Novel 6-pyridyl substituted pyrimidine derivatives are disclosed for use as antiviral agents, particularly for the treatment of retroviral infections such as HIV infections and related disorders, as well as for use in anti-cancer therapies to improve the efficacy of anti-cancer therapeutics. These compounds and their pharmacologically acceptable salts operate to disrupt viral replication an exhibit lower cell toxicity, thereby providing more efficient agents for use alone or in conjunction with other chemical or biological agents to provide prolonged antiviral therapy. In addition, the compounds can be used to increase the efficacy of anti-cancer therapeutics including 5-fluropyrimidines such as 5-fluorouracil, thereby reducing the dosage requirement of the therapeutic in anti-cancer therapies so as to decrease toxic effects to the host.

  披露了一种新型6-吡啶基取代嘧啶衍生物，可用作抗病毒剂，特别用于治疗逆转录病毒感染，如HIV感染和相关疾病，以及用于抗癌治疗，以提高抗癌治疗药物的疗效。这些化合物及其药理学上可接受的盐作用于破坏病毒复制并表现出更低的细胞毒性，从而提供更有效的药剂，可单独使用或与其他化学或生物药剂结合使用，以提供长期的抗病毒治疗。此外，这些化合物还可用于提高抗癌治疗药物的疗效，包括5-氟嘧啶类药物，如5-氟尿嘧啶，从而降低抗癌治疗药物的剂量要求，以减少对宿主的毒性影响。
• Formation of μ4-Se2 complex by the oxidative coupling of μ-SeH complex: double-site atomic inversion of the μ4-Se2 complex [{(Cp*Rh)2(μ-CH2)2}2(μ4-Se2)]2+ (Cp*=η5-C5Me5)
  作者：Hiroshi Shimomura、Takanori Nishioka、Masaaki Abe、Isamu Kinoshita、Kiyoshi Isobe

  DOI：10.1016/s0022-328x(00)00474-5

  日期：2000.10

  A reaction of trans-[(Cp*Rh)(2)(mu-CH2)(2)Cl-2] with H2Se in MeOH formed a mu-SeH complex isolated as a BPh4 salt [(Cp*Rh)(2)(mu-CH2)(2)(mu-SeH)](BPh4) (1; Cp* = eta(5)-C5Me5). In solution, complex 1 was oxidized by molecular oxygen giving a tetranuclear diselenide mu(4)-Se-2 complex [(Cp*Rh)(2)(mu-CH2)(2)}(2)(mu(4)-Se-2)](BPh4), (2). The structure involves Se-2 bridging two Rh-Rh bonds (Rh-Rh = 2.6353(5) Angstrom) in a side-on fashion (Rh(1)-Se(1) = 2.4715(6), Rh(2)-Se(1)* = 2.5526(6) Angstrom). The Se(1)Se(1)* distance is 2.3875(9) Angstrom, which corresponds to a Se-Se single bond. Complex 2 showed an intriguing dynamic behavior of double-site atomic inversion at the selenium atoms in CD3CN. The line shape analyses of the temperature dependent H-1-NMR spectra of the mu-CH2 groups elucidated the dynamic process and provided the activation parameters: Delta H-double dagger = 70 +/- 1 kJ mol(-1), Delta S-double dagger = 15 +/- 5 J mol(-1) K-1, and Delta G(double dagger) = 66 +/- 1 kJ mol(-1) (at 298 K). (C) 2000 Elsevier Science S.A. All rights reserved.