4-hydroxy-3,3-dimethyl-1-oxa-4-azaspiro<4.5>decane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 4-hydroxy-3,3-dimethyl-1-oxa-4-azaspiro<4.5>decane
• 英文别名: 4-Hydroxy-3,3-dimethyl-1-oxa-4-azaspiro[4.5]decane
• 化学式: C₁₀H₁₉NO₂
• 分子量: 185.266
• InChiKey: GTCZVMYOSWFMJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,3-二甲基-1-氧杂-4-氮杂螺[4.5]癸烷 在 sodium tungstate 、 双氧水 作用下， 以 甲醇 、 水 为溶剂， 反应 2.25h， 生成 4-hydroxy-3,3-dimethyl-1-oxa-4-azaspiro<4.5>decane
  参考文献：
  名称：

  Vinyl monomer polymerization inhibition using hindered hydroxylamines

  摘要：

  发现可以通过添加含有受阻羟胺的组合物（以及可选的协同剂）来抑制乙烯芳香化合物（例如苯乙烯）的聚合。在发明的一种实施方案中，受阻N,N-二取代羟胺的化学式为：[(R1R2R3)C]2N—OH，其中R1、R2和R3分别选自氢、直链、支链或环烷基、芳香基、芳基烷基和烷基芳基基团，每个C上的R1、R2和R3中最多只能有两个是氢，一个C上的R1、R2和R3中的一个或多个可以与另一个C上的R1、R2和R3结合形成所选的环烷基和芳烷基基团，任何一个C上的R1、R2和R3中的任意两个可以结合形成环烷基，上述R1、R2和R3的任何定义都可以包含从N、O和S中选择的一个或多个杂原子，受阻N，N-二取代羟胺中的碳原子总数范围为6到70。可选的协同剂可以包括烷基取代的羟基芳香烃，例如2,5-二叔丁基对苯二酚，以及氢转移剂，例如1,2,3,4-四氢萘等，以及它们的混合物。

  公开号：

  US06342647B1

文献信息

• Hindered amine light stabilizer, methods of making, and compositions
  申请人：Campbell H. Donald

  公开号：US20070072964A1

  公开（公告）日：2007-03-29

  A compound in which n is 0, 1, 2, or 3; R 1 , R 2 , R 7 , and R 8 are each independently alkyl group, including cycloalkyl, an alkylaryl group, or an aryl group, optionally with one or more heteroatoms, with the proviso that R 1 and R 2 can together form a cycloalkylene group and, independently, R 7 and R 8 can together form a cycloalkylene group; Y is an oxygen free radical, a sulfur free radical, OR 9 or SR 9 ; R 3 , R 4 , R 5 , R 6 , and R 9 are each independently H or an alkyl group, a cycloalkyl group, an aryl group, or an alkylaryl group, optionally with one or more heteroatoms; and compositions, such as basecoat and clearcoat coating compositions, containing such compounds.

  这是一种化合物，其中n为0、1、2或3；R1、R2、R7和R8分别独立地是烷基，包括环烷基、烷基芳基或芳基，可选地带有一个或多个杂原子，但要求R1和R2可以共同形成环烷基烷基，而独立的R7和R8可以共同形成环烷基烷基；Y是一个氧自由基，硫自由基，OR9或SR9；R3、R4、R5、R6和R9分别独立地是H或烷基、环烷基、芳基或烷基芳基，可选地带有一个或多个杂原子；以及包含这种化合物的组合物，例如底漆和透明漆涂料组合物。
• Vinyl monomer polymerization inhibition using hindered hydroxylamines
  申请人：Baker Hughes Incorporated

  公开号：US06342647B1

  公开（公告）日：2002-01-29

  It has been discovered that the polymerization of vinyl aromatic compounds, such as styrene, may be inhibited by the addition of a composition that contains a hindered hydroxylamine, and, optionally, a synergist together with the hindered hydroxylamine. In one embodiment of the invention, the hindered N,N-disubstituted hydroxylamine has the formula: [(R1R2R3)C]2N—OH where R1, R2, and R3 are independently selected from the group consisting of hydrogen, straight, branched or cyclic alkyl, aryl, aralkyl, and alkaryl moieties; where no more than two of R1, R2, and R3 on each C can be hydrogen at a time; where one or more of R1, R2, and R3 on one C may be joined to a R1, R2, and R3 on the other C to form a cyclic moiety selected from the group consisting of alkylene, and aralkylene moieties; where any two of the R1, R2, and R3 on any one C may be joined together to form a cycloalkyl; where any of the above definitions of R1, R2, and R3 may contain one or more heteroatoms selected from the group consisting of N, O and S; and where the total number of carbon atoms in the hindered N,N-disubstituted hydroxylamine ranges from 6 to 70. Optional synergists may include alkyl-substituted hydroxyarenes such as 2,5-di-tert-butylhydroquinone, and hydrogen transfer agents such as 1,2,3,4-tetrahydronaphthalene; and the like, and mixtures thereof.

  发现可以通过添加含有受阻羟胺的组合物（以及可选的协同剂）来抑制乙烯芳香化合物（例如苯乙烯）的聚合。在发明的一种实施方案中，受阻N,N-二取代羟胺的化学式为：[(R1R2R3)C]2N—OH，其中R1、R2和R3分别选自氢、直链、支链或环烷基、芳香基、芳基烷基和烷基芳基基团，每个C上的R1、R2和R3中最多只能有两个是氢，一个C上的R1、R2和R3中的一个或多个可以与另一个C上的R1、R2和R3结合形成所选的环烷基和芳烷基基团，任何一个C上的R1、R2和R3中的任意两个可以结合形成环烷基，上述R1、R2和R3的任何定义都可以包含从N、O和S中选择的一个或多个杂原子，受阻N，N-二取代羟胺中的碳原子总数范围为6到70。可选的协同剂可以包括烷基取代的羟基芳香烃，例如2,5-二叔丁基对苯二酚，以及氢转移剂，例如1,2,3,4-四氢萘等，以及它们的混合物。
• Candle wax stabilized with oxazolidines
  申请人：——

  公开号：US20030000128A1

  公开（公告）日：2003-01-02

  White, dyed, dipped, unscented and/or scented candle wax is effectively stabilized against discoloration and fading by the incorporation therein of an oxazolidine in combination with a UV absorber and/or an antioxidant.

  白色、染色、浸渍、无味和/或有香味的蜡烛蜡通过添加一种氧杂环己烷与UV吸收剂和/或抗氧化剂的组合物，可以有效地稳定其颜色和防止褪色。
• Inhibition of pulp and paper yellowing using nitroxides, hydroxylamines and other coadditives
  申请人：——

  公开号：US20020124980A1

  公开（公告）日：2002-09-12

  Pulps or papers, especially chemimechanical or thermomechanical pulps or papers, which still contain lignin, have enhanced resistance to yellowing when they contain an effective stabilizing amount of a hindered amine compound which preferably is a nitroxide, a hydroxylamine or an ammonium salt thereof. This performance is often further enhanced by the presence of one or more coadditives selected from the group consisting of the UV absorbers, the polymeric inhibitors, the nitrones, the fluorescent whitening agents, metal chelating agents, sulfur containing stabilizers, metal salts and diene compounds. Combinations of nitroxides, hydroxylamines or their salts, benzotriazole or benzophenone UV absorbers and a metal chelating agent are particularly effective. Selected derivatives of 1-oxyl-2,2,6,6-tetramethyl-piperidin-4-ol and selected hydroxylamine salts are novel compounds and are surprisingly effective for this purpose.

  含有木质素的纸浆或纸张，特别是化学机械或热机械纸浆或纸张，如果它们含有有效的阻化胺化合物（最好是亚硝基自由基，羟胺或其铵盐），则具有增强的抗黄变性能。当与来自紫外线吸收剂、聚合抑制剂、亚硝基醇、荧光增白剂、金属螯合剂、含硫稳定剂、金属盐和二烯化合物等组成的一种或多种协同添加剂一起使用时，通常可以进一步提高其性能。亚硝基自由基、羟胺或其盐、苯并三唑或苯并酚类紫外线吸收剂和金属螯合剂的组合尤其有效。选择的1-氧基-2,2,6,6-四甲基哌啶-4-醇和选择的羟胺盐衍生物是新的化合物，出乎意料地有效。
• Process for producing a shaped product
  申请人：Menicon Co., Ltd.

  公开号：EP0921134A1

  公开（公告）日：1999-06-09

  A process for producing a shaped product, which comprises polymerizing a mixture comprising a radical scavenger, a polymerization initiator and a radical polymerizable monomer to obtain a partially polymerized mixture having the conversion of the monomer into the polymer of from 5 to 90 wt%, filling the partially polymerized mixture in a predetermined cavity and then applying polymerization energy to complete polymerization.

  一种生产成型产品的工艺，包括聚合由自由基清除剂、聚合引发剂和可自由基聚合的单体组成的混合物，以获得部分聚合的混合物，其单体转化为聚合物的转化率为 5 至 90 wt%，将部分聚合的混合物填充到预定的空腔中，然后施加聚合能量以完成聚合。