(S)-2,8-Dimethyl-1,3-dioxa-8-aza-spiro[4.5]decane | 104925-22-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: (S)-2,8-Dimethyl-1,3-dioxa-8-aza-spiro[4.5]decane
• 英文别名: (2S)-2,8-dimethyl-1,3-dioxa-8-azaspiro[4.5]decane
• CAS: 104925-22-6
• 化学式: C₉H₁₇NO₂
• 分子量: 171.24
• InChiKey: VHBBMEXIWWKUNY-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• IMIDAZOYL PYRIDINE COMPOUNDS AND SALTS THEREOF
  申请人：KIMURA Teiji

  公开号：US20110065696A1

  公开（公告）日：2011-03-17

  A compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar 1 represents an imidazolyl group or the like which may be substituted with a C1-6 alkyl group, Ar 2 represents a phenyl group or the like which may be substituted with a C1-6 alkoxy group, X 1 represents a double bond or the like and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, is effective as a therapeutic or prophylactic agent for a disease caused by Aβ.

  化合物的化学式为(I)或其药理学上可接受的盐，其中Ar1代表咪唑基团或类似基团，该基团可能被C1-6烷基取代，Ar2代表苯基或类似基团，该基团可能被C1-6烷氧基取代，X1代表双键或类似基团，Het代表三唑基团或类似基团，该基团可能被C1-6烷基或类似基团取代，可用作治疗或预防由Aβ引起的疾病的药物。
• POLYCYCLIC COMPOUND
  申请人：Kimura Teiji

  公开号：US20110009619A1

  公开（公告）日：2011-01-13

  Disclosed is a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, which is effective as a therapeutic or prophylactic agent for a disease induced by Aβ, wherein Ar 1 represents an imidazolyl group which may be substituted with a C1-6 alkyl group, or the like; Ar 2 represents a phenyl group which may be substituted with a C1-6 alkoxy group, or the like; X 1 represents a double bond, or the like; and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, or the like.

  本发明涉及一种化合物，其化学式为(I)：或其药学上可接受的盐，该化合物有效地作为由Aβ引起的疾病的治疗或预防剂。其中，Ar1表示咪唑基，可以用C1-6烷基等取代；Ar2表示苯基，可以用C1-6烷氧基等取代；X1表示双键等；Het表示三唑基等，可以用C1-6烷基等取代。
• CINNAMIDE COMPOUNDS FOR DEMENTIA
  申请人：Miyagawa Takehiko

  公开号：US20100130537A1

  公开（公告）日：2010-05-27

  The invention provides methods for treating, preventing, and delaying the onset of dementia and mild cognitive impairments by administering to a patient in need thereof at least one cinnamide compound and one or more second-line active ingredients, such as cholinesterase inhibitors; AMPA receptor antagonists; NMDA receptor antagonists; and the like. The invention also provides pharmaceutical compositions, combinations, and kits.
• US7935815B2
  申请人：——

  公开号：US7935815B2

  公开（公告）日：2011-05-03
• US8673964B2
  申请人：——

  公开号：US8673964B2

  公开（公告）日：2014-03-18