2-chloro-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane 2-oxide | 60146-70-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: 2-chloro-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane 2-oxide
• 英文别名: 2,3-dimethyl-2,3-butylene phosphorochloridate；2-Chloro-4,4,5,5-tetramethyl-1,3,2lambda5-dioxaphospholane 2-oxide；2-chloro-4,4,5,5-tetramethyl-1,3,2λ5-dioxaphospholane 2-oxide
• CAS: 60146-70-5
• 化学式: C₆H₁₂ClO₃P
• 分子量: 198.586
• InChiKey: OTWQWRXGCPQHJQ-UHFFFAOYSA-N

物化性质

• 沸点：
  154.4±9.0 °C(Predicted)
• 密度：
  1.23±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-chloro-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane 2-oxide 、 Phenyl 3,4,6-tri-O-benzyl-1-thio-β-D-glucopyranoside 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以65%的产率得到phenyl 3,4,6-tri-O-benzyl-2-O-(1,1,2,2-tetramethyl-dimethylene phosphonoyl)-β-D-thioglucopyranoside
  参考文献：
  名称：

  EP1849794

  摘要：

  公开号：
• 作为产物：
  描述：

  频哪醇 在 三氯氧磷 作用下， 生成 2-chloro-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane 2-oxide
  参考文献：
  名称：

  [EN] DELIVERY OF THERAPEUTIC ALKALOID COMPOUNDS
  [FR] ADMINISTRATION DE COMPOSÉS ALCALOÏDES THÉRAPEUTIQUES

  摘要：

  Disclosed are compounds that can be converted to mesembrine under physiologically relevant conditions, and related methods of preparing and using the compounds.

  公开号：

  WO2024026059A2

文献信息

• Determination of Water Content in Olive Oil by ³¹P NMR Spectroscopy
  作者：Emmanuel Hatzakis、Photis Dais

  DOI：10.1021/jf073227n

  日期：2008.3.1

  A method for moisture determination in olive oil using 31P NMR spectroscopy is developed. This method is based on the replacement of the hydrogen atoms of water molecules with the tagging agents 2-chloro-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane and diphenylphosphinic chloride. Both reagents were successful in determining moisture in olive oil. However, only the second reagent provided a clean and

  开发了一种使用31P NMR光谱法测定橄榄油中水分的方法。该方法基于用标记剂2-氯-4,4,5,5-四甲基-1,3,2-二氧杂膦烷和二苯基次膦酰氯代替水分子的氢原子。两种试剂均能成功测定橄榄油中的水分。然而，只有第二种试剂在温和的条件下提供了干净而即时的反应，而没有与第一种试剂所观察到的副反应。进行了研究比较，以评估当前的NMR分析方法与完善的Karl Fischer滴定方法之间的一致性。
• PROCESS FOR PRODUCING 1,2-TRANS-GLYCOSIDE COMPOUND
  申请人：Otsuka Chemical Co., Ltd.

  公开号：EP1849794A1

  公开（公告）日：2007-10-31

  In preparing a glycoside compound from (a) a furanose compound or pyranose compound, and (b) an alcohol compound, a process for preparing a glycoside compound in which glycosidic bond locates selectively trans form relative to C-2 hydroxyl group, the process comprising using a furanose compound wherein the hydroxyl at the 2-position may have a substituent protected with a group A, or a pyranose compound which may have a substituent wherein R2 and R3 are the same or different and are each alkyl having 1 to 4 carbon atoms or aryl having or not having a substituent, or R2 and R3 are combined to form alkylene having 2 to 4 carbon atoms (the alkylene may be substituted with alkyl having 1 to 4 carbon atoms, or may have intervening phenylene), and m and n are each an integer of 0 or 1.

  在从(a)呋喃糖化合物或吡喃糖化合物和(b)醇化合物制备苷化合物时，制备苷键相对于 C-2 羟基选择性地反式定位的苷化合物的工艺，该工艺包括使用呋喃糖化合物，其中 2 位的羟基可能具有被 A 基团保护的取代基，或使用吡喃糖化合物，其中可能具有取代基 其中R2和R3相同或不同，各自为具有1至4个碳原子的烷基或具有或不具有取代基的芳基，或R2和R3结合形成具有2至4个碳原子的亚烷基(该亚烷基可被具有1至4个碳原子的烷基取代，或可有中间的亚苯基)，m和n各自为0或1的整数。
• Process for Producing 1,2-Trans-Glycoside Compound
  申请人：Yamago Shigeru

  公开号：US20080177049A1

  公开（公告）日：2008-07-24

  In preparing a glycoside compound from (a) a furanose compound or pyranose compound, and (b) an alcohol compound, a process for preparing a glycoside compound in which glycosidic bond locates selectively trans form relative to C-2 hydroxyl group, the process comprising using a furanose compound wherein the hydroxyl at the 2-position may have a substituent protected with a group A, or a pyranose compound which may have a substituent wherein R 2 and R 3 are the same or different and are each alkyl having 1 to 4 carbon atoms or aryl having or not having a substituent, or R 2 and R 3 are combined to form alkylene having 2 to 4 carbon atoms (the alkylene may be substituted with alkyl having 1 to 4 carbon atoms, or may have intervening phenylene), and m and n are each an integer of 0 or 1.
• US8212013B2
  申请人：——

  公开号：US8212013B2

  公开（公告）日：2012-07-03
• US8664372B2
  申请人：——

  公开号：US8664372B2

  公开（公告）日：2014-03-04